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| 1 | Effect of vitamin E and human placenta cysteine peptidase inhibitor on expression of cathepsins B and L in implanted hepatoma Morris 5123 tumor model in Wistar rats显示文摘AIM: To examine the effectiveness of human placental inhibitors, by injecting vitamin E to rats with transplanted Norris-5123 hepatoma, on the expression of cathepsins B and L in tumor, liver, lung and blood sera after transplantation of Norris 5123 hepatoma.METHODS: Animals were divided into 10 groups receiving three different concentrations of vitamin E and inhibitors along or in combination and compared with negative control (healthy rats) and positive control (tumor rats). Effectiveness of treatment was evaluated with regard to survival time,tumor response and determination of the activities of proteolytic enzymes and their inhibitors using flurogenic substrates.RESULTS: Cathepsins B and L activities were elevated by 16-fold in comparison with negative control tissues, and their endogenous inhibitor activity decreased by 1.2-fold before treatment. In several cases, tumors completely disappeared following vitamin E plus human placental cyteine protease inhibitor (CPI) compared with controls.The number of complete tumor responses was higher when 20 m/kg vitamin E plus 400 μg of CPI was used, i.e.7/10 rats survived more than two mo. Cathepsins B and L were expressed significantly in tumor, liver, lung tissues and sera in parallel to the increasing of the endogenous inhibitor activity compared with the controls after treatment (P<0.0001).CONCLUSION: The data indicate formation of metastasis significantly reduced in treated rats, which might provide a therapeutic basis for anti-cancer therapy. | Tadeusz Sebzda Piotr Hanczyc Yousif Saleh Bernice F Akinpelumi Maciej Siewinski Jerzy Rudnicki | 2005 | World Journal of Gastroenterology2005，11，4： | 2 |
| 2 | Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk 显示文摘 | Abtahian F Guerriero A Sebzda E | 2003 | Science2003，299，10： | 1 |
| 3 | Regulation of blood and lymphatic vascular sepration by signaling proeins sip-76 and Syk 显示文摘 | Abtahian F Guerriero A Sebzda E | 2003 | Science2003，299，5604： | 1 |
| 4 | Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk显示文摘 | Abtahian F Guerriero A Sebzda E | 2003 | Science2003，299，5604： | 1 |
| 5 | Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk显示文摘 | Abtahian F Guerriero A Sebzda E | 2003 | Science2003，299，5604： | 1 |
| 6 | Selection of the T cell repertoire显示文摘 | Sebzda E Mariathasan S Ohteki T | | 0，，0： | 1 |
| 7 | Selection of the T repertoire显示文摘 | Sebzda E Mariathasan S Ohteki T | 1999 | Annual Review of Immunology1999，17，： | 1 |
| 8 | Syk and S1p-76 mutant mice reveal a cell-autonomous hematopoietic cell contribution to vascular development显示文摘 | Sebzda E Hibbard C Sweeney S | 2006 | Dev Cell2006，11，3： | 1 |
| 9 | Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk显示文摘 | Abtabian F Guerriero A Sebzda E | 2003 | Science2003，299，5604： | 1 |
| 10 | Expression of cystatin C in clinical human colorectal cancer tissues 显示文摘 | Saleh Y Sebzda T Warwas M etal | 2005 | J Exp Ther Oncol2005，5，1： | 1 |
| 11 | Selection of the T cell repertoire显示文摘 | Sebzda E Mariathasan S Ohteki T | 1999 | Annu Rev Immmunol1999，17，： | 1 |
| 12 | Expression of cystatin C in clinical human colorectal cancer tissues 显示文摘 | Saleh Y Sebzda T Warwas M | 2005 | J Experimental Therapeutics and Oncology2005，5，1： | 1 |
| 13 | Transcription factor KLF2 regulates the migration of naive T cells by restricting chemokine receptor ex- pression patterns显示文摘 | Sebzda E Zou Z Lee J S | 2008 | Nat Immunol2008，9，3： | 1 |
| 14 | Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk显示文摘 | Abtahian F Guerriero A Sebzda E | 2003 | Science2003，299，5604： | 1 |
| 15 | Cathepsin D expression in human colorectal cancer: relationship with tumor type and tissue differentiation grade 显示文摘 | Sebzda T Saleh Y Gburek J | 2005 | J Exp Ther Oncol2005，5，2： | 1 |
| 16 | Expression of cystatin C in clinical human colorectal cancer tissues显示文摘 | Salch Y Sebzda T Warwas M | 2005 | J Exp Ther Oncol2005，5，1： | 1 |
| 17 | Cathepsin D expression in human colorectal cancer: relationship with tumour type and tissue differentia- tion grade显示文摘 | Sebzda T Saleh Gburek J | 2005 | J Exp Ther Oneol2005，5，2： | 1 |
| 18 | Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk显示文摘 | Abtahian F Guerriero A Sebzda E | 2003 | Science2003，299，5604： | 1 |
| 19 | Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk 显示文摘 | Abtahian F Guerriero A Sebzda E | 2003 | Science2003，299，5604： | 1 |
| 20 | Regulation of blood and lymphatic vascular separation by signaling proteins SLP-76 and Syk显示文摘 | ABTAHIAN F GUERRIERO A SEBZDA E | 2003 | Science2003，299，5604： | 1 |
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