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| 1 | Single-center study comparing computed tomography colonography with conventional colonoscopy显示文摘AIM:To compare the results from computed tomography (CT) colonography with conventional colonoscopy in symptomatic patients referred for colonoscopy. METHODS: The study included 227 adult outpatients, mean age 60 years, with appropriate indications for colonoscopy. CT colonography and colonoscopy were performed on the same day in a metropolitan teaching hospital. Colonoscopists were initially blinded to the results of CT colonography but there was segmental unblinding during the procedure. The primary outcome measures were the sensitivity and specificity of CT colonography for the identification of polyps seen at colonoscopy (i.e. analysis by polyp). Secondary outcome measures included an analysis by patient, extracolonic findings at CT colonography, adverse events with both procedures and patient acceptance and preference. RESULTS: Twenty-five patients (11%) were excluded from the analysis because of incomplete colonoscopy or poor bowel preparation that affected either CT colonography, colonoscopy or both procedures. Polyps and masses (usually cancers) were detected at colonoscopy and CT colonography in 35% and 42% of patients, respectively. Of nine patients with a finaldiagnosis of cancer, eight (89%) were identified by CT colonography as masses (5) or polyps (3). For polyps analyzed according to polyp, the overall sensitivity of CT colonography was 50% (95% CI, 39%-61%) but this increased to 71% (95% CI, 52%-85%) for polyps ≥ 6 mm in size. Similarly, specificity for all polyps was 48% (95% CI, 39%-58%) increasing to 67% (95% CI, 56%-76%) for polyps ≥ 6 mm. Adverse events were uncommon but included one colonic perforation at colonoscopy. Patient acceptance was high for both procedures but preference favoured CT colonography. CONCLUSION: Although CT colonography was more sensitive in this study than in some previous studies, the procedure is not yet sensitive enough for widespread application in symptomatic patients. | Ian C Roberts-Thomson Graeme R Tucker Peter J Hewett Peter Cheung Ruben A Sebben EE Win Khoo Julie D Marker Wayne K Clapton | 2008 | World Journal of Gastroenterology2008，14，3： | 4 |
| 2 | Occurrence of tetrodotoxin and its analogues in the Brazillian frog Brachycephalus ephippium ( Anura: Brachycepha lidae ) 显示文摘 | Pires O R Sebben A Schwartz E F | 2002 | Toxicon2002，40，6： | 1 |
| 3 | The occurrence of 11-oxotetrodotoxin,a rare tetrodotoxin analogue,in the brachycephalidae frog,Brachycephatus ephippium显示文摘 | PIRES O R SEBBEN A SCHWARTZ E F | 2003 | Toxicon2003，42，： | 1 |
| 4 | Production of soybean phosphatidylcholine-chitosan nanovesicles by reverse phase evaporation:a step by step study 显示文摘 | MERTINS O SEBBEN M PHOLMANN A R | 2005 | Chem Lipids2005，138，12： | 1 |
| 5 | Production of soybean phosphatidylcholine-chitosan nanovesicles by reverse phase evaporation: a step by step study 显示文摘 | MERTINS O SEBBEN M POHLMANN A R | 2005 | Chem Phys Lipids2005，138，12： | 1 |
| 6 | Occurrence of tetrodotoxin and its analogues in the Brazilian frog Brachycephalus ephippium ( Anura : Brachycephalidae) 显示文摘 | PIRES JR O R SEBBEN A SCHEARTZ E F | 2002 | Toxicon2002，40，： | 1 |
| 7 | Antimicrobial peptides from anurans skin secretions 显示文摘 | Nascimento A C Fontes W Sebben A | 2003 | Protein Peptide Lett2003，10，3： | 1 |
| 8 | Production of soybean phosphatidylcholine-chitosan nanovesicles by reverse phase evaporation: a step by step study 显示文摘 | MERTINS O SEBBEN M POHLMANN A R | 2005 | Chem Phys Lipids2005，138，29： | 1 |
| 9 | Establishment of a long-term primary culture of striatal neurons 显示文摘 | Sebben M Gabrion J Dumuis A | 1990 | Brain Res Dev Brain Res1990，52，12： | 1 |
| 10 | Antimicrobial peptides from the Brazilian frog Phyllomedusa distincta 显示文摘 | BATISTA C V DA SILVA L R SEBBEN A | 1999 | Peptides1999，20，6： | 1 |
| 11 | Antimicrobial peptides from anurans skin secretions 显示文摘 | NASCIMENTO A C FONTES W SEBBEN A | 2003 | Protein and Peptide Letters2003，10，3： | 1 |
| 12 | Occurrence of tetrodotoxin and its analogues in the Brazilian frog Brachycephalus ephippium(Anura:Brachycephalidae)显示文摘 | Pires OR Jr Sebben A Schwartz EF | 2002 | Toxicon2002，40，6： | 1 |
| 13 | Occurrence of tetrod -otoxin and its analogues in the Brazillianfrog Brachycepha lus -ephippium (Anura: Brachycepha lidae) 显示文摘 | PIRES O R SEBBEN A SCHWARTZ E F | 2002 | Toxicon2002，40，6： | 1 |
| 14 | Occur- rence of tetrodotoxin and its analogues in the Brazilian frog Brachyeephalus ephippium ( Anura: Brachycephalidae) 显示文摘 | PIRES O R SEBBEN A SCHWARTZ E F | 2002 | Toxieon2002，40，6： | 1 |
| 15 | The gastrointestinal prokinetic benzamide derivatives are agonists at the non-classical 5-HT receptor (5-HT4) positively coupled to adenylate cyclase in neurons显示文摘 | Dumuis A Sebben M Bockaert J | 1989 | Naunyn Schrniedeberss Arch Pharmacol1989，340，： | 1 |
| 16 | Occurrence of tetrodotoxin and its analogues in the Brazillian frog Brachyce phalus ephippium ( Anura: Brachycepha lidae )显示文摘 | Pires 0 R Sebben A Schwartz E F | 2002 | Toxicion2002，40，6： | 1 |
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