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| 1 | Pelvic exenterations for primary rectal cancer:Analysis from a 10-year national prospective database显示文摘AIM To identify short-term and oncologic outcomes of pelvic exenterations(PE) for locally advanced primary rectal cancer(LAPRC) in patients included in a national prospective database.METHODS Few studies report on PE in patients with LAPRC. For this study, we included PE for LAPRC performed between 2006 and 2017, as available, from the Rectal Cancer Registry of the Spanish Association of Surgeons [Asociación Espa?ola de Cirujanos(AEC)]. Primary endpoints included procedure-associated complications, 5-year local recurrence(LR), disease-free survival(DFS) and overall survival(OS). A propensitymatched comparison with patients who underwent non-exenterative surgery for low rectal cancers was performed as a secondary endpoint.RESULTS Eight-two patients were included. The mean age was 61.8 ± 11.5 years. More than half of the patients experienced at least one complication. Surgical site infections were the most common complication(abdominal wound 18.3%, perineal closure 19.4%). Thirty-three multivisceral resections were performed, including two hepatectomies and four metastasectomies. The long-term outcomes of the 64 patients operated on before 2013 were assessed. The five-year LR was 15.6%, the distant recurrence rate was 21.9%, and OS was 67.2%, with a mean survival of 43.8 mo. R+ve resection increased LR [hazard ratio(HR) = 5.58, 95%CI: 1.04-30.07, P = 0.04]. The quality of the mesorectum was associated with DFS. Perioperative complications were independent predictors of shorter survival(HR = 3.53, 95%CI: 1.12-10.94, P = 0.03). In the propensity-matched analysis, PE was associated with better quality of the specimen and tended to achieve lower LR with similar OS.CONCLUSION PE is an extensive procedure, justified if disease-free margins can be obtained. Further studies should define indications, accreditation policy, and quality of life in LAPRC. | Gianluca Pellino Sebastiano Biondo Antonio Codina Cazador JoséMaría Enríquez-Navascues Eloy Espín-Basany Jose Vicente Roig-Vila Eduardo García-Granero | 2018 | World Journal of Gastroenterology2018，24，45： | 1 |
| 2 | Differential expression of connective tissue growth factor in inflammatory bowel disease显示文摘 | Di Mola FF Di Sebastiano P Gardini A | 2004 | Digestion2004，69，4： | 1 |
| 3 | 3T MRI evaluation of the accuracy of atlas-based subtha- lamic nucleus identification 显示文摘 | STANCANELLO J MUACEVIC A SEBASTIANO F | 2008 | Med Pbys2008，35，7： | 1 |
| 4 | Differential expression of connective tissue growth factor in inflammatory bowel disease显示文摘 | Di Mola FF Di Sebastiano P Gardini A | 2004 | Digestion2004，69，4： | 1 |
| 5 | Separation of fatty alcohol polyethoxylates by capillary electrophoresis through easy electroosmotic flow control with a quaternary diammonium salt显示文摘 | Citterio A Righetti P G | 2004 | J Chromatogr A2004，1053，： | 1 |
| 6 | Multiscale unsupervised change detection on optical images by Markov random fields and wavelets显示文摘 | GABRIELE M ELENA A SEBASTIANO B S | 2011 | IEEE Geoscience and Remote Sensing Letters2011，8，4： | 1 |
| 7 | A modified fast-track program for pancreatic surgery: a prospective single-center experi- ence显示文摘 | di Sebastiano P Festa L De Bonis A | 2011 | Langenbecks Arch Surg2011，396，3： | 1 |
| 8 | Diffusion dynamics in small-world networks with heterogeneous consumers显示文摘 | Sebastiano A D Jager W Janssen M A | 2007 | Computational & Mathematical Or- ganization Theory2007，13，2： | 1 |
| 9 | Trainees' reactions to training:shaping groups and courses for happier trainees in an italian context显示文摘 | A Giangreco A Carngati A Sebastiano | 2010 | The International Journal of Human Resources Management2010，21，13： | 1 |
| 10 | Trainees' reactions to training:an analysis of the factors affecting overall satisfaction with training显示文摘 | A Giangreco A Sebastiano R Peccei | 2009 | The International Journal of Human Resources Management2009，20，1： | 1 |
| 11 | Dif-fusion dynamics in small-world networks with heterogeneousconsumers 显示文摘 | Sebastiano A Delre Wander Jager Marco A Janssen | 2007 | Computational and Mathematical Organiza-tion Theory2007，13，2： | 1 |
| 12 | Capillary electrophoresis and isoelectric focusing in peptide and protein analysis 显示文摘 | Righettip G Sebastiano R Citterio A | 2013 | Proteomics2013，13，2： | 1 |
| 13 | Capillary electropho- resis and isoelectric focusing in peptide and protein analysis显示文摘 | Righetti P G Sebastiano R Citterio A | 2013 | Proteomics2013，13，2： | 1 |
| 14 | War outside, ceasefire inside : An analysis of the performance appraisal system of a public hospital in a zone of conflict 显示文摘 | Giangreco A Carugati A Sebastiano A | 2012 | Eval Program Plann2012，35，1： | 1 |
| 15 | Molecular marker-assisted introgression of the wild Solarium commersonii genome into the cultivated gene pool 显示文摘 | Barone A Sebastiano A Carputo D | 2001 | Theor Appl Genet2001，102，： | 1 |
| 16 | The role of organisational commitment in the analysis of resistance to change: Co-predictor and moderator effects 显示文摘 | Peccei R Giangreco A Sebastiano A | 2011 | Personnel Review2011，40，2： | 1 |
| 17 | A 65 nm CMOS temperature-compensated mobility-based frequency reference for wireless sensor networks显示文摘 | Fabio Sebastiano Lucien J Breems Kofi A A Makin- wa | 2011 | IEEE Journal of Solid-state Circuits2011，46，7： | 1 |
| 18 | Conjugated linoleic acid-enriched butter fat alters mammary gland morphogenesis and reduces cancer risk in rats 显示文摘 | Clement IP Sebastiano B Elisabetta A | 1999 | Nutr1999，129，： | 1 |
| 19 | Differential expression of connective tissue growth factor in inflammatory bowel disease显示文摘 | di Mola FF Di Sebastiano P Gardini A | | 0，，： | 1 |
| 20 | The role of organizational commitment in the analysis of resistance to change: Co-pre- dictor and moderator effects显示文摘 | Peccei R Giangreeo A and Sebastiano A | 2011 | Personnel Review2011，40，2： | 1 |
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