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| 1 | In vitro Response of Human Mesenchymal Stromal Cells to Titanium Coated Peek Films and Their Suitability for Magnetic Resonance Imaging显示文摘Medical imaging is an important tool for the post-operative checkup of an accurate position of an implant as well as for monitoring the integration in the adjacent tissue that may influence the success of a medical device.Unfortunately,the possibility to use imaging methods is associated with the implant material and all the established metallic materials for surgery do not show a proper 'imaging compatibility'.The present study is a combined investigation of the in vitro response to human mesenchymal stromal cells(hMSC) and magnetic resonance imaging(MRI) compatibility of the potential material combination polyetheretherketone/titanium(PEEK/Ti) for medical devices.Because of the advantageous imaging properties and the mechanical and chemical stability,PEEK becomes more and more an alternative to common metallic implant materials like titanium or cobalt-chrome.However,PEEK is a bioinert material having a limited ability for direct bone incorporation.Due to its excellent biocompatibility,Ti was chosen as coating material to enhance the cellular response.The result is a combination with advantageous properties:the magnetic susceptibility and elastic modulus close to bone,corrosion resistance and mechanical flexibility of PEEK and the excellent biocompatibility of titanium.The appearance of metal-related artifact was discussed in electrical resistivity and magnetic susceptibility.Therefore,two titanium coatings have been investigated:a complete coating and a structured surface avoiding surface conductivity.To determine the in vitro biocompatibility,the cell responses were assessed in terms of the overall morphology of the hMSC and their cell area distribution,proliferation,osteogenic differentiation and mineral deposition.The cellular stress was evaluated by the prostaglandin E_2 level.The bonded materials both produced no disturbing artifacts in magnetic resonance imaging.Compared to the pure PEEK material,the titanium coated specimens showed an enhanced biocompatibility,which is indicated by a higher cell number,larger activity of the enzyme tissue non-specific alkaline phosphatase and therefore a greater amount of deposited calcium and phosphate.The results on bare PEEK are accompanied with a higher cellular stress level,which is indicated by prostaglandin E_2. | Cindy Elschner Carolin Noack Carolin PreilBler Andreas Krause Ulrich Scheler Ute Hempel | 2015 | Journal of Materials Science & Technology2015，31，5： | 3 |
| 2 | Parameters influencing porosity in sandstones:a model for sandstone porosity prediction显示文摘 | Scheler M | 1987 | AAPG bulletin1987，71，： | 1 |
| 3 | Modification of perfluorinated polymers by high-energy irradiation 显示文摘 | LUNKWITZ K LAPPAN U SCHELER U | 2004 | Journal of Fluorine Chemistry2004，125，6： | 1 |
| 4 | A Quantitative Analysis of Aspects in the eCos Kernel显示文摘 | Daniel Lohmann Fabian Scheler Reinhard Tartler etc | 2006 | Proceedings of the2006，1，： | 1 |
| 5 | Disorders of coronary microcirculation and arrhythm ias in system ie arterial hyperyension显示文摘 | Vot M Motz W Scheler S | 1990 | Am J Cardiol1990，65，： | 1 |
| 6 | Detection of NASBA amplified bacterial tmRNA molecules on SLICSel designed microarray probes显示文摘 | Scheler O Kaplinski L Glynn B | 2011 | BMC Biotechnol2011，11，： | 1 |
| 7 | Vacuum-assisted breast biopsy: a comparison of 11-gauge and 8-gauge needles in benign breast disease显示文摘 | Hahn M Okamgba S Scheler P | 2008 | World J Surg Oncol2008，19，6： | 1 |
| 8 | Effect of diabetes mellitus on corneal biomechanics and measurement of intraocular pressure显示文摘 | Scheler A Spoerl E Boehm AG | 2012 | Acta Ophthalmol2012，90，： | 1 |
| 9 | Peptide mass fingerprint sequence coverage from differently stained proteins on two-dimensional electrophoresis patterns by matrix assisted laser desorption/ionization-mass spectrometry (MALDI-MS)显示文摘 | Scheler C Lamer S Pan Z | 1998 | Electrophoresis1998，19，： | 1 |
| 10 | Vacuum-assisted breast biop- sy : a comparison of 11-gauge and 8-gauge needles in benign breast disease显示文摘 | Hahn M Okamgba S Scheler P | 2008 | World journal of Surgical 0ncology2008，6，： | 1 |
| 11 | Magnetic brain source imaging of focal epileptic activity:a synopsis of 455 cases显示文摘 | Stefan H Hummel C Scheler G | 2003 | Brain2003，126，11： | 1 |
| 12 | Myocardial preconditioning and remote renal preconditioning identifying a protective factor using proteomic methods?显示文摘 | Lang SC Elsasser A Scheler C | 2006 | Basic Res Cardiol2006，101，2： | 1 |
| 13 | Mineralisation of chitosan scaffolds with nano-apatite formation by double diffusion technique 显示文摘 | Manjubala I Scheler S Bossert J | 2006 | Acta Biomaterialia2006，2，1： | 1 |
| 14 | Vacuum-assisted breast biopsy:a comparison of 11-gauge and 8-gauge needles in benign breast disease显示文摘 | Hahn M Okamgba S Scheler P | 2008 | World J Surg Oncol2008，6，： | 1 |
| 15 | New aspects of transversal 1 H-NMR relaxation in natural rubber vulcanizates显示文摘 | U. Heuert M. Kn?rgen H. Menge G. Scheler H. Schneider | 1996 | Polymer Bulletin1996，，4： | 1 |
| 16 | Vacuum-assisted breast biopsy:a comparison of 11-gauge and 8-gauge needles in be- nign breast disease显示文摘 | Hahn M Okamgba S Scheler P | 2008 | World J Surg Oncol2008，6，： | 1 |
| 17 | Epilepsy surgery,resection volume and MSI localization in 1esional frontal lobe epilepsy 显示文摘 | Genow A Hummel C Scheler G et a1 | 2004 | Neuroimage2004，21，1： | 1 |
| 18 | Vacuum - assisted breast biopsy: a comparison of 11 - gauge and 8 - gauge needles in benign breast disease 显示文摘 | Hahn M Okamgba S Scheler P | 2008 | World J surg Oncol2008，19，6： | 1 |
| 19 | Blood levels of branched-chain alpha-keto acids in uremia: therapeutic implications显示文摘 | SCHAUDER P MATCHAEI D SCHELER F | 1979 | Klin Wochensch V1979，57，16： | 1 |
| 20 | Hand-held ultrasound-guided vacuum biopsy of mammary lesions-first experiences显示文摘 | Scheler P Poltow B Hahn M | 2000 | Zentralbl Gynakol2000，122，9： | 1 |
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