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| 1 | 多重耐药铜绿假单胞菌对头孢洛扎-他唑巴坦的敏感性和药敏试验方法的比较显示文摘由多重耐药(MDR)铜绿假单胞菌引起的感染呈现上升趋势,特别是在危重患者中,导致相关感染的发病率和病死率增加。目前对MDR铜绿假单胞菌感染的治疗可选药物很少。2014年和2015年,美国FDA和欧洲药品管理局(EMA)相继分别批准了头孢洛扎-他唑巴坦用于治疗复杂性尿路感染和腹腔感染2项适应证。该复合制剂与头孢他啶相比,对AmpC酶更稳定,对铜绿假单胞菌的青霉素结合蛋白(PBP)有较高的亲和力,可有效地穿透缺失孔蛋白的外膜蛋白,并在有外排泵存在的细胞周质中发挥抗菌作用。因此头孢洛扎-他唑巴坦可用于治疗MDR铜绿假单胞菌所致感染。但该复合制剂对产金属酶(MBL)的菌株无效。本文主要评估MDR和广泛耐药(XDR)铜绿假单胞菌对该药的耐药率、潜在的耐药基因、克隆结构,并比较不同药敏试验方法对测试头孢洛扎-他唑巴坦的准确性。 | SCHAUMBURG F BLETZ S MELLMANN A 郭燕 朱德妹 | 2018 | 中国感染与化疗杂志2018，18，4： | 2 |
| 2 | Prevalence of peripheral neuropathy in injection drug users显示文摘 | Berger AR Schaumburg HH | 1999 | Neurology1999，53，： | 1 |
| 3 | Population dynamics among methicillin-resistant Staphylococcus aureus isolates in Germany during a 6-year period显示文摘 | Schaumburg F K(o)ck R Mellmann A | 2012 | J Clin Microbiol2012，50，10： | 1 |
| 4 | Fatty acid abnormality in adrenoleukodystrophy显示文摘 | Igarashi M Schaumburg HH Powers J | 1976 | J Neurochem1976，26，： | 1 |
| 5 | Ocular surface APCs are necessary for autoreactive T cell-mediated experimental autoimmune lacrimal keratoconjunctivitis 显示文摘 | Schaumburg CS Siemasko KF de Paiva CS | 2011 | J Immuno12011，187，： | 1 |
| 6 | Infusion, core decompression, or infusion following core decompression in the treatment of bone edema syndrome and early avaseular osteonecrosis of the femoral head 显示文摘 | Beckmann J Schmidt T Schaumburger J | 2013 | Rheu- matol Int2013，33，6： | 1 |
| 7 | Jump-robust volatility estimation using nearest neighbor truncation显示文摘 | Torben G. Andersen Dobrislav Dobrev Ernst Schaumburg | 2012 | Journal of Econometrics2012，，1： | 1 |
| 8 | -Conformation of polythiophene derivatives in solution显示文摘 | Schaumburg K Bjornholm T | 1998 | Synthetic Metals1998，97，： | 1 |
| 9 | The enlarging view of hexacarbon neurotoxicity显示文摘 | Spencer PS Schaumburg HH Sabri MI | 1980 | Crit Rev Toxicol1980，7，： | 1 |
| 10 | Effects of hypergly cemia on rat cavernous nerve axons : a functional and uh rastructural study显示文摘 | Zotova EG Schaumburg HH Raine CS | 2008 | Exp Neuro12008，213，2： | 1 |
| 11 | Encephalopathy from abuse of bismuth subsalicylate (Pepto-Bismol)显示文摘 | Alexander C. Jungreis Herbert H. Schaumburg | 1993 | Neurology1993，，6： | 1 |
| 12 | Adrenoleukodystrophy:a clinical and pathological study of 17 cases显示文摘 | Schaumburg HH Powers JM Raine CS | 1975 | Arch Neurol1975，32，： | 1 |
| 13 | On the specific molecular configuration of neurotoxic aliphatic hexacarbon compounds causing central-peripheral distal axonopathy显示文摘 | Spencer PS Bischoff MC Schaumburg HH | 1978 | Toxicol Appl Pharmacol1978，44，： | 1 |
| 14 | Hypertension intracerebral hematoma,an investigation of the initial hemorrhage and rebleeding using chromiumCrs-labeled erythrocytes显示文摘 | Herbstein D J Schaumburg H H | 1974 | Arch Neurol1974，30，3： | 1 |
| 15 | Degeneration in central and peripheral nervous systems produced by pure n -hexane, an experimental study 显示文摘 | Schaumburg HH Spencer PC | 1976 | Brain1976，99，： | 1 |
| 16 | Micro Molding Behaviour of Engineering Plastics 显示文摘 | O Kemmann C Schaumburg L Weber | 1999 | Proceedings of SPIE Design Test and Microfabrication of MEMS and MOEMS1999，3680，： | 1 |
| 17 | Dry eye as a mucosal autoimmune disease显示文摘 | Stern ME Schaumburg CS Pflugfelder SC | 2013 | Int Rev Immunol2013，，： | 1 |
| 18 | High-melt-strength PP显示文摘 | M Schaumburg | 1997 | Plastics World1997，55，7： | 1 |
| 19 | Direct inhibition of cytochrome C-induced caspase activation in vitro by Toxoplasma gondii reveals novel mechanisms of interference with host cell apoptosis显示文摘 | Keller P Schaumburg F Fischer SF | 2006 | FEMS Microbiol Lett2006，258，： | 1 |
| 20 | A Closer Look at the Short-Term Return Reversal 显示文摘 | Zhi Da Qianqiu Liu Ernst Schaumburg | 2014 | Management Science2014，60，3： | 1 |
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