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| 1 | Relationship between Crohn’s disease, infection with Mycobacterium avium subspecies paratuberculosis and SLC11A1 gene polymorphisms in Sardinian patients显示文摘AIM: To study the association between Crohn’s disease (CD), Mycobacterium avium subspecies paratubercu- losis (MAP), and genetic factors by examining the role of natural resistance-associated macrophage protein 1 (NRAMP1) gene polymorphisms (now SLC11A1) in Sar dinian patients with CD and controls. METHODS: Thirty-seven CD patients and 34 controls with no inflammatory bowel disease (IBD) were recruited at the University of Sassari after giving written con sent. Six SCL11A1 polymorphisms previously reported to be the most significantly associated with IBD were searched. M. paratuberculosis was identified by IS900 PCR and sequencing. Logistic regression was used to cal culate odds ratios (OR) for the associations among CD presence of MAP, and 6 loci described above. RESULTS: For the first time, a strong association was observed between polymorphisms at NRAMP1 locus 823C/T and CD. While CD was strongly associated withboth NRAMP1 and MAP, NRAMP1 polymorphisms and MAP themselves were not correlated. CONCLUSION: Combined with previous work on the NOD2/CARD15 gene, it is clear that the interplay of ge- netic, infectious, and immunologic factors in the etiology of CD is complex. | Leonardo A Sechi Maria Gazouli Lee E Sieswerda Paola Molicotti Niyaz Ahmed John Ikonomopoulos Antonio M Scanu Daniela Paccagnini Stefania Zanetti | 2006 | World Journal of Gastroenterology2006，12，44： | 3 |
| 2 | Lp(a)Lipoprotein-coping with heterogeneity显示文摘 | Scanu A M | 2003 | N EngL Med2003，349，20： | 1 |
| 3 | Lopoproteim(a) and the atherothro,botic provess:mechanistic insights and cLinicaL impLications显示文摘 | Scanu A M | 2003 | Curr AtheroscLer Rep2003，5，： | 1 |
| 4 | Use of a reference material proposed by the International Federation of Clinical Chemistry and Laboratory Medicine to evaluate analytical methods for the determination of plasma lipoprotein(a)显示文摘 | Albers J J Scanu A M | 2000 | Clin Chem2000，46，12： | 1 |
| 5 | Effect of Triton on lipoprorein lipase of rat plasma 显示文摘 | Schotz M C Scanu A Page I H | 1957 | Amer J Physiol1957，188，： | 1 |
| 6 | Studies of human serum high density lipoproteins显示文摘 | Vitetto L B Scanu A M | 1969 | J Biol Chem1969，251，： | 1 |
| 7 | Lipoprotein (a) and datherosclerosis显示文摘 | Scanu A W Lawn R M Bergk | 1991 | Ann Inter Med1991，115，3： | 1 |
| 8 | Genetic basis and pathophysiological implica tions of high plasma Lp(a) levels显示文摘 | Scanu A M | 1992 | J Inten Med1992，231，6： | 1 |
| 9 | Tissue type plasminogen activator binds to and is inhibited by surface-bound lipoprotein (a) and low-density hpoprotein 显示文摘 | Simon D I Fless G M Scanu A M | 1991 | Biochemistry1991，30，27： | 1 |
| 10 | Lipoprotein(a) and atherosclerosis显示文摘 | Scanu A M Lawn R M Bergk | 1991 | Ann Intern Med1991，115，： | 1 |
| 11 | Use of a ref- erence material proposed by the International Federation of Clinical Chemistry and Laboratory Medicine to evaluate ana- lytical methods for the determination of plasma lipoprotein(a) 显示文摘 | Marcovina S M Albers J J Scanu A M | 2000 | Clin Chem2000，46，12： | 1 |
| 12 | LP(a)and atheroslerosis 显示文摘 | Scanu A M Lawn R M Berg K | 2002 | Ann Intern Med2002，15，2： | 1 |
| 13 | Use of a reference material proposed by the international federation of clinical chemistry and laboratory medicine to evaluate analytical methods for the determination of plasma lipoprotein(a)显示文摘 | Marcovina S M Albers J J Scanu A M | 2000 | Clin Chem2000，46，12： | 1 |
| 14 | Demonstration that the enzyme that converts precursor of apolipoprotein A- I to apolipoprotein A- I is secreted by the hepatocareinoma cell line Hep G2显示文摘 | Edelstein C Kaiser M Piras G Scanu A M | 1988 | Arch Biochem Biophys1988，267，： | 1 |
| 15 | Effect of Triton on lipoprotein lipase of rat plasma显示文摘 | Schotz M C Scanu A Page I H | 1957 | Amer J Physiol1957，188，： | 1 |
| 16 | Use of a reference material proposed by the International Federation of Clinical Chemistry and Laboratory Medicine to evaluate analytical methods for the determination of plasma lipoprotein(a) 显示文摘 | Marcovina S M Albers J J Scanu A M | 2000 | Clin Chem2000，46，12： | 1 |
| 17 | Methods of isolation and purification of protein显示文摘 | | 1969 | Biochemistry1969，8，： | 1 |
| 18 | Viability Property for a Backward Stochastic Differential Equation and Applications to Partial Differential Equations显示文摘 | Buckdahn R Quincampoix M Rǎscanu A | 2000 | Probab Theory Relat Fields2000，116，4： | 1 |
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