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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Neocryptolepine analogues containing N-substituted side-chains at C-11: Synthesis and antischistoso micidal activity显示文摘 | Sayed I E Ramzy F William S | 2012 | Medicinal Chemistry Research2012，21，12： | 1 |
| 3 | A new fluorescent 'turn-on' chemodosimeter for the detection of hydrogen sulfide in water and living cells显示文摘 | Sayed S E I Torre C D L Santos-Figueroa L E | 2013 | Advances2013，3，25： | 1 |
| 4 | Studies on europium separation from a middle rare earth concentrate by in situ zinc reduction technique 显示文摘 | Sayed S A Rabie K A Salama I E | 2005 | Separation and Purification Technology2005，46，3： | 1 |
| 5 | Characterization of some lead vanadate glasses显示文摘 | SADDEEK Y B SHAABAN E R ALY K A SAYED I M | 2009 | Journal of Alloys and Compounds2009，478，： | 1 |
| 6 | Inhibitory effect of yoghurt and soya yoghurt containing bifidobacteria on the prolifer- ation of Ehrlich ascites tumour cells in vitro and in vivo in a mouse tumour model显示文摘 | Abd El - Gawad I El - Sayed E Hafez S | 2004 | Brit J Nutr2004，92，1： | 1 |
| 7 | Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development显示文摘 | EI Sayed R Szakal A K | 2006 | Eur J Immunol2006，36，： | 1 |
| 8 | Effect of sulfide ions on the stress corrosion behaviour of Al-brass and Cu10Ni alloys in salt water显示文摘 | Sayed S M Ashour E A Youssef G I | 2002 | Jonrnal of Materials Science2002，37，11： | 1 |
| 9 | Active secretion of drug form the intestinal epithelium in rats by P-glycoprotein functioning as an absorption barrier 显示文摘 | Hisanaga E Sai Y Tamai I Tsuji A | 1996 | J Pharm Pharmacol1996，48，10： | 1 |
| 10 | Effect of sulfide ions on the stress corrosion behaviour of Al- brass and Cu - 10Ni alloys in salt water显示文摘 | Sayed S M Ashour E A Youssef G I | 2002 | Journal of Materials Science2002，37，： | 1 |
| 11 | Effect of sulfide ions on the corrosion behavior of Al-brass and Cu10Ni alloys in salt water显示文摘 | Sayed S M Ashour E A Youssef G I | 2003 | Mater Chem Phys2003，78，： | 1 |
| 12 | Clinico-pathological Study of Atypical Pathogens in Community-Acquired Pneumonia:a Prospective Study 显示文摘 | E I Sayed Zaki M Goda T | 2009 | J Infect Dev Ctries2009，3，： | 1 |
| 13 | Fk)w Through Porous Media-the Ergun Equation Revisited 显示文摘 | MacdoMd I F Sayed M S E I Mow K | 1979 | Industrial Engineering Chemistry1979，18，3： | 1 |
| 14 | Correlation between factors controlling preparation of porous copper via sintering technique using experimental design 显示文摘 | AHMED Y M Z RIAD M I SAYED A S AHLAM M K SHALABI M E H | 2007 | Powder Technology2007，175，： | 1 |
| 15 | Synthesis andantiplasmodial activity of aminoalkylamino-substituted neo-cryptolepine derivatives显示文摘 | Sayed I E’Van der Veken P Steert K | 2009 | 7 Med Chem2009，52，9： | 1 |
| 16 | Effect of sulfide ions on the stress corrosion behaviour of Al-brass and Cu10Ni alloys in salt water显示文摘 | SAYED S M ASHOUR E A YOUSSEF G I | 2002 | Journal of Materials Science2002，37，： | 1 |
| 17 | Effect of sulfide ions on the stress corrosion behaviour of Al-brass and Cu10Ni alloys in salt water显示文摘 | Sayed S M Ashour E A Youssef G I | 2002 | Journal of Materials Science2002，37，： | 1 |
| 18 | Effect of sulfide ions on the stress corrosion behaviour of Al-brass and Cu-10Ni alloys in salt water显示文摘 | Sayed S M A shour E A Youssef G I | 2002 | Journal of Materials Science2002，37，： | 1 |
| 19 | Determination of pefloxacin and its main active metabolite in human serum by high performance liquid chromatography显示文摘 | Abanmi N Zaghloul I Sayed N E | 1996 | Therapeutic Drug Monitoring1996，18，2： | 1 |
| 20 | Studies on europiumseparation from a middle rare earth concentrate by in situzinc reduction technique显示文摘 | Sayed S A Rabie K A Salama I E | 2005 | Separation and PurificationTechnology2005，46，3： | 1 |
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