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| 1 | Role of hepatocyte nuclear factor 4-alpha in gastrointestinal and liver diseases显示文摘Hepatocyte nuclear factor 4-alpha(HNF4α)is a highly conserved member of nuclear receptor superfamily of ligand-dependent transcription factors that is expressed in liver and gastrointestinal organs(pancreas,stomach,and intestine).In liver,HNF4αis best known for its role as a master regulator of liver-specific gene expression and essential for adult and fetal liver function.Dysregulation of HNF4αexpression has been associated with many human diseases such as ulcerative colitis,colon cancer,maturity-onset diabetes of the young,liver cirrhosis,and hepatocellular carcinoma.However,the precise role of HNF4αin the etiology of these human pathogenesis is not well understood.Limited information is known about the role of HNF4αisoforms in liver and gastrointestinal disease progression.There is,therefore,a critical need to know how disruption of the expression of these isoforms may impact on disease progression and phenotypes.In this review,we will update our current understanding on the role of HNF4αin human liver and gastrointestinal diseases.We further provide additional information on possible use of HNF4αas a target for potential therapeutic approaches. | Matthew M Yeh Dustin E Bosch Sayed S Daoud | 2019 | World Journal of Gastroenterology2019，25，30： | 5 |
| 2 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 3 | Interaction of insulin with prokinetic drugs in STZ-induced diabetic mice显示文摘AIM:To study the possible interactions of metoclopramide,domperidone and erythromycin in streptozotocin-induced diabetic mice treated with insulin by various parameters.METHODS:Effects of the individual as well as combined drugs were studied in diabetic mice via estimation of the blood glucose and serum insulin levels,small intestinal transit(SIT),gastric emptying(GE),xylose absorption and glucose tolerance tests.Groups were given insulin 2 IU/kg s.c.,metoclopramide 20 mg/kg p.o.,domperidone 20 mg/kg p.o.and erythromycin 6 mg/kg p.o.individually and in combination.There were also normal and diabetic control groups.The first set of experiments was carried out to investigate the subchronic effect on blood glucose and serum insulin levels in diabetic mice of one week of daily dose administration of the tested drugs individually as well as the combination of insulin with each prokinetic drug.The other five sets of experiments were carried out to investigate the acute effect of a single dose of each drug individually and in combination on blood glucose and serum insulin levels,SIT,GE,oral xylose absorption and glucose tolerance tests.RESULTS:The study included the prokinetic drugs metoclopramide(20 mg/kg),domperidone(20 mg/kg) and erythromycin(6 mg/kg),as well as insulin(2 IU/kg),which was individually effective in decreasing SIT,enhancing GE and increasing xylose absorption significantly in diabetic mice.Erythromycin tended to decrease blood glucose level and increase serum insulin level after 1 wk of daily administration in diabetic mice.Erythromycin potentiated the effect of insulin on blood glucose level and serum insulin level whereas other prokinetic agents failed to do so after repeated dose administration in diabetic mice.Metoclopramide or erythromycin in combination with insulin significantly decreased SIT,in diabetic mice,to lower levels than with insulin alone.Administration of prokinetic drugs along with insulin antagonized the action of insulin on xylose absorption.These combinations also increased the rate of glucose absorption from the gut.CONCLUSION:The present study suggests that prokinetic drugs could potentially improve glycemic control in diabetic gastroparesis by allowing a more predictable absorption of nutrients,matched to the action of exogenous insulin.The use of prokinetics,such as erythromycin,may be interesting in the clinic in decreasing the need for insulin in diabetic patients.The dose of insulin may be safely decreased with erythromycin in chronic treatments. | Mohamed A Fouad Shalaby Hekma A Abd El Latif Mostafa E El Sayed | 2013 | World Journal of Gastrointestinal Pharmacology and Therapeutics2013，4，2： | 3 |
| 4 | The role of fringing coral reef in beach protection of Hurghada, Gulf of Suez, Red Sea of Egypt显示文摘 | Frihy O E El Ganaini M A El Sayed W R | 2004 | Ecological Engineering2004，22，1： | 1 |
| 5 | Deep neck space Abscesses显示文摘 | Dousary A L | 1996 | J Otolaryngol1996，25，4： | 1 |
| 6 | Hepatic complications of antituberculosis therapy revisited显示文摘 | Cohen C D Sayed A R Kirsch R E | 1983 | S Afr Med J1983，63，： | 1 |
| 7 | Traveling- wave -based fault- location scheme for multiend- aged underground cable system显示文摘 | GILANY M G IBRAHIM D K SAYED E | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 8 | Experimental study of turbulent flow inside a circular tube with longitudinal interrupted fins in the streamwise direction显示文摘 | SAAD A E SAYED A E MOHAMED E A | 1997 | Experimental qlaermal Fluid Science1997，15，1： | 1 |
| 9 | Elevated tissue expression of thrombomodulatory factors correlates with acute symptomatic carot- id plaque phenotype显示文摘 | Sayed S Cockerill GW Torsney E | 2009 | Eur J Vase Endovasc Surg2009，38，1： | 1 |
| 10 | Neocryptolepine analogues containing N-substituted side-chains at C-11: Synthesis and antischistoso micidal activity显示文摘 | Sayed I E Ramzy F William S | 2012 | Medicinal Chemistry Research2012，21，12： | 1 |
| 11 | Stress corrosion behavior of α-aluminum bronze in saline water显示文摘 | Ateya B G Ashour E A Sayed S M | 1994 | Corrosion1994，50，1： | 1 |
| 12 | Coordination compounds of hydrazine derivatives with transition metals III: The reaction of aroyl hydrazones with Ni( Ⅲ ) and Cu ( Ⅱ ) salts显示文摘 | Sayed L E Iskander M F | 1971 | J Inorg Nucl Chem1971，33，2： | 1 |
| 13 | L- arginine augments the antioxidant effect of garlic against acetic acid - induced ulcerative colitis in rats显示文摘 | Harisa G E Abo - Salem O M E1 - Sayed el - S M | 2009 | Pak J Pharm Sci2009，22，4： | 1 |
| 14 | Hemoglobin, a biologic fenton reagent显示文摘 | Graf E Panter SS | 1984 | J Biol Chem1984，259，14： | 1 |
| 15 | A new steel anchorage system for post-tensioning applications using carbon fibre reinforced plastic tendons 显示文摘 | SAYED A E Y SHRIVE N G | 1998 | Can J Civil Eng1998，25，1： | 1 |
| 16 | Marine natural products as prototype agrochemieal agents 显示文摘 | Peng J G Shen X Y Sayed K E | 2003 | J Agric Food Chem2003，51，8： | 1 |
| 17 | Thioredoxin glutathi- one reductase from Schistosoma mansoni: an essential parasite enzyme and a key drug target显示文摘 | Kuntz AN Davioud-Charvet E Sayed AA | 2007 | PLoS Med2007，，6： | 1 |
| 18 | New aspects in probucol cardioprotection against doxorubicin-induced cardiotoxicity显示文摘 | El-Bemerdash E Ali AA Sayed -Ahmed MM Osman AM | 2003 | Cancer Chemother Pharmacol2003，52，5： | 1 |
| 19 | Fuzzy Controller for Inverter Fed Induction Machines 显示文摘 | Sayed A Mir Zinger Malik E Elbuluk | 1994 | IEEE Trans on Industry Application1994，30，4： | 1 |
| 20 | Domain analysis of electromagnetic transients on nonuniform lines显示文摘 | Saied M M Alfuhaid A S Elshandwily M E | 1990 | IEEE Trans on Power Delivery1990，5，4： | 1 |
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