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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Traveling- wave -based fault- location scheme for multiend- aged underground cable system显示文摘 | GILANY M G IBRAHIM D K SAYED E | 2007 | IEEE Transactions on Power Delivery2007，22，1： | 1 |
| 3 | Marine natural products as prototype agrochemieal agents 显示文摘 | Peng J G Shen X Y Sayed K E | 2003 | J Agric Food Chem2003，51，8： | 1 |
| 4 | Directional solidification of polycrystalline silicon ingots by successive relaxation of supercooling method 显示文摘 | Arafune K Ohishi E Sai H | 2007 | Jottrnal of Crystal Growth2007，308，1： | 1 |
| 5 | Improved corneal bioavailability of ofloxacin:biodegradable microsphere-loaded ion-activated in situ gel delivery system显示文摘 | SAYED E G HUSSEIN A K KHALED K A | 2015 | Drug Design Development and Therapy2015，9，9： | 1 |
| 6 | Liquid phasemixing in turbulent bed contactor 显示文摘 | Bruce A E R Sai P S T Krishnaiah K | 2003 | Chemical Engineering Science2003，，58： | 1 |
| 7 | Study of surfactant level in cases of primary atrophic rhinitis 显示文摘 | Sayed R H Abou-Elhamd K E Abdel-Kader M | 2000 | J Laryngol Otol2000，114，4： | 1 |
| 8 | Isolation of mers coronavirus from a dromedary camel, qatar, 2014显示文摘 | Raj V S Farag E A Reusken C B Lamers M M Pas S D Voermans J Smits S L Osterhaus A D A1- Mawlawi N Al-Romaihi H E A1Hajri M M E1- Sayed A M Mohran K A Ghobashy H Alhajri F A1-Thani M A1-Marri S A El-Maghraby M M Koopmans M P Haagmans B L | 2014 | Emerg Infect Dis2014，20，8： | 1 |
| 9 | Liquid holdup in turbulent bed contactor显示文摘 | Bruce A E R Sai P S T Krishnaiah K | 2004 | Chemical Engineering Journal2004，99，3： | 1 |
| 10 | Characterization of liquid phase mixing in turbulent bed contactor through RTD studies显示文摘 | Bruce A E R Sai P S T Krishnaiah K | 2004 | Chemical Engineering Journal2004，104，： | 1 |
| 11 | Studies on europium separation from a middle rare earth concentrate by in situ zinc reduction technique 显示文摘 | Sayed S A Rabie K A Salama I E | 2005 | Separation and Purification Technology2005，46，3： | 1 |
| 12 | Characterization of some lead vanadate glasses显示文摘 | SADDEEK Y B SHAABAN E R ALY K A SAYED I M | 2009 | Journal of Alloys and Compounds2009，478，： | 1 |
| 13 | Moving Object Detection Inspatial Domain Using Background Removal Techniques--State-of-Art显示文摘 | Elhabian S Sayed K E Ahmed S | 2008 | Recent Patents on Computer Science2008，，1： | 1 |
| 14 | Directional solidifica tion of polycrystalline silicon ingots by successive relaxation of su percooling method显示文摘 | ARAFUNE K OHISHI E SAI H | 2007 | Journal of Crystal Growth2007，308，1： | 1 |
| 15 | A new norcem- branoid dimer from the red sea soft coral Sinularia gardineri显示文摘 | SAYED K A E HAMANN M T | 1996 | J Nat Prod1996，59，7： | 1 |
| 16 | Potential of various drugs to inhibit nucleoside uptake in rat syncytiotrophoblast cell line, TR-TBT 18d-1 显示文摘 | Chishu T Sai Y Nishimura T Sato K Kose N Nakashima E | 2008 | Placenta2008，29，5： | 1 |
| 17 | Follicular dendritic cell (FDC)-FcgammaRIIB engagement via immune complexes induces the activated FDC phenotype associated with secondary follicle development显示文摘 | EI Sayed R Szakal A K | 2006 | Eur J Immunol2006，36，： | 1 |
| 18 | Effects of hypotonic stress on the survival of mouse oocytes and embryos at various stages显示文摘 | Pedro P B Zhu S E Makino N Sakurai T Edashige K Ka sai M | 1997 | Cryobiolo- gy1997，35，： | 1 |
| 19 | Increased cystatin C levels as a risk factor of cardiovasculai' events in patients with pre- served estimated glomerular filtration rate after elective percuta- neous coronary intervention with drug-eluting stents显示文摘 | Sai E Shimada K Miyauchi K | 2015 | Heart and vessels2015，，： | 1 |
| 20 | Directional solidification of polycrystalline silicon ingots by successive relaxation of super- cooling method]显示文摘 | ARAFUNE K OHISHI E SAI H et aI | 2007 | Journal of Crystal Growth2007，308，1： | 1 |
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