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| 1 | 基于贝叶斯信息准则的非侵入式负荷事件检测算法显示文摘用户负荷数据监测是实现需求侧管理的基础,非侵入式负荷监测技术是负荷监测的重要发展方向,而事件检测是非侵入式负荷监测中的一个关键环节。对适用于模型选取问题的贝叶斯信息准则进行建模,将贝叶斯信息准则首次运用到事件检测当中,利用快速事件检测算法降低贝叶斯信息准则检测算法的误检率,并能解决CUSUM算法中产生的漏检问题。最后采用真实数据集进行测试。实验结果表明,相比于CUSUM算法,基于贝叶斯信息准则的事件检测算法能达到更好的检测准确性,并且能明显提高计算运行的速度。 | 肖江 Francois AUGER 荆朝霞 Sarra HOUIDI | 2018 | 电力系统保护与控制2018，46，22： | 20 |
| 2 | Genetic Diversity and Structure of Tunisian Local Pear Germplasm as Revealed by SSR Markers显示文摘Growing pear has a long tradition in Tunisia, and numerous local cultivars possessing an excellent adaptability and resilience potential to climatic variation are present. This large adaptability is associated with an important genetic diversity, which is threatened to erosion.Appropriate measures have to be taken in order to properly evaluate and conserve this local material. Microsatellite markers were used to assess the level of genetic diversity among Tunisian pear germplasm, and compare it with some European varieties and wild pear species. 61 pear accessions representing eight groups(six groups from Tunisia, one from Northern Europe and another group composed of wild pear) have been genotyped using SSR markers derived from apple and pear. The pear accessions showed a significant polymorphism and 95 polymorphic alleles were found. The number of alleles per locus varied from 5 for CH04e03 locus to 14 for CH01d09 locus with an average of 9.4 alleles per locus.Moreover, the mean gene diversity(H_e) per locus ranged from 0.192 to 0.752. Genetic distance values and cluster analyses revealed high genetic similarities among the Tunisian groups. Factorial correspondence analysis(FCA) categorized the accessions into three independent groups where Tunisian local accessions agglomerated together distantly from European and wild pear accessions. Additionally, UPGMA dendrogram grouped accessions into two clusters, confirmed thereafter by the Bayesian model-based Structure analysis. The results showed 16 putative triploid accessions found in the local germplasm. This study provides valuable information to develop strategies of local pear conservation and use. | Rim Ouni Anna Zborowska Jasna Sehic Sarra Choulak JInaki Hormaza Larisa Garkava-Gustavsson Messaoud Mars | 2020 | Horticultural Plant Journal2020，6，2： | 18 |
| 3 | 连接肽在融合蛋白设计中的选择及应用显示文摘融合蛋白的设计中,经常需要用链接肽将不同功能的蛋白进行连接融合。连接肽的设计和选择对融合蛋白的表达、稳定性及功能活性至关重要。文章将常见的两种连接肽分为柔性(Flexibility)和刚性(Rigidity)进行比较说明。其中柔性连接肽即成柔软线性的一类易弯折的氨基酸序列,常见为(GGGGS)。重复序列(n=3—4);刚性连接肽即成稳固螺旋结构的一类长度固定的氨基酸序列,常见为(EAAAK)。重复序列(n=2~5)。设计连接肽时应考虑长度、氨基酸成分、亲水性、构象、柔韧性及电荷等因素。连接肽中的氨基酸组成对柔性连接肽影响较大,而氨基酸排列影响着刚性连接肽的结构。文章结合近年来融合蛋白设计中两种最常用连接肽的相关报道进行阐述,为连接肽的研究提供参考。 | 于健 Sarra Setrerrahmane 徐寒梅 | 2016 | 药物生物技术2016，23，3： | 13 |
| 4 | Interleukin-21 triggers effector cell responses in the gut显示文摘In the gut of patients with Crohn's disease and patients with ulcerative colitis,the major forms of inflammatory bowel diseases(IBD) in humans,the tissue-damaging immune response is mediated by an active cross-talk between immune and non-immune cells.Accumulating evidence indicates also that cytokines produced by these cells play a major role in initiating and shaping this pathologic process.One such cytokine seems to be interleukin(IL)-21,a member of the common γ-chainreceptor family.IL-21 is produced in excess in the in-flamed intestine of patients with IBD mostly by activated CD4+ T helper cells co-expressing interferon-γ and follicular T helper cells.Moreover,both in vitro and in vivo studies indicate that excessive IL-21 production leads to the activation of multiple signaling pathways that expand and sustain the ongoing mucosal inflammation.In this article,we review the available data supporting the pathogenic role of IL-21 in IBD. | Daniela De Nitto Massimiliano Sarra Francesco Pallone Giovanni Monteleone | 2010 | World Journal of Gastroenterology2010，16，29： | 8 |
| 5 | 基于非侵入式的事件检测方法统计评估显示文摘非侵入式负荷监测是负荷监测的重要发展方向,事件检测是非侵入式负荷监测的重点研究内容。多维信号相比一维信号可以提供多源信息,若信号不同维度间相关度大,则可以提高检测精度。文章基于统计假设首次推导BIC、CUSUM和GLRT三种算法的决策函数,并以二维信号为例进行仿真实验,比较了三种算法的检测结果。仿真实验证明补充合适的第二维信号可以提高整体检测精度,且得到不同算法的适用条件,即CUSUM算法适用于高阈值检测,GLRT算法适用于低阈值检测。 | 张露 Francois Auger 荆朝霞 Sarra Houidi Huu Kien Bui 肖江 | 2020 | 电测与仪表2020，57，1： | 5 |
| 6 | Trends in insulin resistance:insights into mechanisms and therapeutic strategy显示文摘The centenary of insulin discovery represents an important opportunity to transform diabetes from a fatal diagnosis into a medically manageable chronic condition.Insulin is a key peptide hormone and mediates the systemic glucose metabolism in different tissues.Insulin resistance(IR)is a disordered biological response for insulin stimulation through the disruption of different molecular pathways in target tissues.Acquired conditions and genetic factors have been implicated in IR.Recent genetic and biochemical studies suggest that the dysregulated metabolic mediators released by adipose tissue including adipokines,cytokines,chemokines,excess lipids and toxic lipid metabolites promote IR in other tissues.IR is associated with several groups of abnormal syndromes that include obesity,diabetes,metabolic dysfunction-associated fatty liver disease(MAFLD),cardiovascular disease,polycystic ovary syndrome(PCOS),and other abnormalities.Although no medication is specifically approved to treat IR,we summarized the lifestyle changes and pharmacological medications that have been used as efficient intervention to improve insulin sensitivity.Ultimately,the systematic discussion of complex mechanism will help to identify potential new targets and treat the closely associated metabolic syndrome of IR. | Mengwei Li Xiaowei Chi Ying Wang Sarra Setrerrahmane Wenwei Xie Hanmei Xu | 2022 | Signal Transduction and Targeted Therapy2022，7，8： | 5 |
| 7 | CD5 expression promotes IL-10 production through activation of the MAPK/Erk pathway and upregulation of TRPC1 channels in B lymphocytes显示文摘CD5 is constitutively expressed on T cells and a subset of mature normal and leukemic B cells in patients with chronic lymphocytic leukemia(CLL).Important functional properties are associated with CD5 expression in B cells,including signal transducer and activator of transcription 3 activation,IL-10 production and the promotion of B-lymphocyte survival and transformation.However,the pathway(s)by which CD5 influences the biology of B cells and its dependence on B-cell receptor(BCR)co-signaling remain unknown.In this study,we show that CD5 expression activates a number of important signaling pathways,including Erk1/2,leading to IL-10 production through a novel pathway independent of BCR engagement.This pathway is dependent on extracellular calcium(Ca2+)entry facilitated by upregulation of the transient receptor potential channel 1(TRPC1)protein.We also show that Erk1/2 activation in a subgroup of CLL patients is associated with TRPC1 overexpression.In this subgroup of CLL patients,small inhibitory RNA(siRNA)for CD5 reduces TRPC1 expression.Furthermore,siRNAs for CD5 or for TRPC1 inhibit IL-10 production.These findings provide new insights into the role of CD5 in B-cell biology in health and disease and could pave the way for new treatment strategies for patients with B-CLL. | Soizic Garaud Taher E Taher Marjolaine Debant Miguel Burgos Sarra Melayah Christian Berthou Kaushal Parikh Jacques-Olivier Pers Damien Luque-Paz Gilles Chiocchia Maikel Peppelenbosch David A Isenberg Pierre Youinou Olivier Mignen Yves Renaudineau Rizgar A Mageed | 2018 | Cellular & Molecular Immunology2018，15，2： | 2 |
| 8 | Centranthera grandiflore alleviates alcohol-induced oxidative stress and cell apoptosis显示文摘Alcohol liver disease(ALD)has become a global threat to human health.It is associated with a wide range of liver diseases including alcohol fatty liver,steatosis,fibrosis and cirrhosis,and finally leads to liver cancer and even death.Centranthera grandiflora is a traditional Chinese medicinal herb commonly used to treat ALD,but no research about its mechanism is available.This study evaluated the hepatoprotective effect and mechanism of C.grandiflora against alcohol-induced liver injury in mice.We found that the ethanol extracts of C.grandiflora(CgW)alleviated the alcohol-induced liver injury,enhanced the levels of antioxidant enzymes,and reduced the amount of lipid peroxides.CgW also affected cell apoptosis by inhibiting the activity of Bax,cleaved-caspase 3 and cleaved-caspase 9,and increasing the activity of Bcl-2.In conclusion,the results showed that CgW can effectively improve ALD through alleviating oxidative stress and inhibiting cell apoptosis for the first time.This study suggested that C.grandiflora is a promising herbal medicine for ALD treatment. | GAO Xin-Mei DONG Wen-Han XIA Chun-Lei MA Zhuo-Yi WANG Ying SARRA Setrerrahmane XU Han-Mei QI Wei-Yan | 2022 | Chinese Journal of Natural Medicines2022，20，8： | 2 |
| 9 | Regulation of gut inflammation and th17 cell response by interleu- kin-21显示文摘 | Fina D Sarra M Fantini MC | 2008 | Gastroenterology2008，134，4： | 1 |
| 10 | Fluid flow and pumping efficiency in an ejector-venturi scrubber 显示文摘 | XAVIER G SARRA M JAVIER LAFUENTE F | 2004 | Chemical and Engineering Processing2004，43，2： | 1 |
| 11 | Influence of the vertical profile of Saharan dust on the visible direct radiative forcing显示文摘 | Meloni D Sarra A D lorio T D | 2005 | Journal of Quantitative Spectroscopy and Radiative Transfer2005，93，4： | 1 |
| 12 | Gene replacement therapy in the retinal degeneration mouse: the effect on retinal degeneration following partial transduction of the retinal显示文摘 | Sarra GM Stephens C de Alwis M | 2001 | Hum Mol Gene2001，10，21： | 1 |
| 13 | Interleukin-21 in chronic inflammatory diseases显示文摘 | Sarra M Pallone F Monteleone G | 2013 | Biofactors2013，39，4： | 1 |
| 14 | Metabolic inflexibility is a feature of women with polycysticovary syndrome and is associated with both insulin resistance and hyperandrogenism显示文摘 | Di Sarra D Tosi F Bonin C | 2013 | J Clin Endocrimol Metab2013，98，6： | 1 |
| 15 | IL 23/ IL-17 axis in IBD显示文摘 | SARRA M PALLONE F MACDONALD T T | 2010 | Inflamm Bowel Dis2010，16，10： | 1 |
| 16 | Heritable transmission of diabetic metabolic memory in zebrafish correlates with DNA hypomethylation and aberrant gene expression显示文摘 | Olsen AS Sarras MP Jr Leontovich A | 2012 | Diabetes2012，61，2： | 1 |
| 17 | Restoration of photoreceptor ultrastructure and func- tion in retiiml degeneration slow mice by gene therapy显示文摘 | Ali RR Sarra GM Stephens C Alwis MD Bainbriclge JW Mtmro PM | 2000 | Nat Genet2000，25，3： | 1 |
| 18 | Restoration of photoreceptor ultrastructure and function in retinal degeneration slow mice by gene therapy 显示文摘 | Ali RR0 Sarra GM Stephens C Alwis MD Bainbridge JW Munro PM | 2000 | Nat Genet2000，25，3： | 1 |
| 19 | IL-21 promotes skin recruitment of CD4(+)cells and drives IFN-γ-dependent epidermal hyperplasia显示文摘 | Sarra M Caruso R Cupi M L | 2011 | J Immunol2011，186，9： | 1 |
| 20 | Gene replaomaent therapy in the retinal degeneration slow (rds) mouse: the effect on retinal degeneration following partial transduction of the retina 显示文摘 | Sarra GM Stephens C de Alwis M Bainbridge JW Smith AJ Thrasher AJ | 2001 | Hum Mol Gene2001，10，21： | 1 |
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