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	题名	作者	年代	出处	被引量
1	Telomerase and mTOR in the brain:the mitochondria connection显示文摘Telomerase is an enzyme that maintains telomeres in dividing cells using a template on its inherent RNA component.Additionally,the protein part TERT(Telomerase Reverse Transcriptase) has various non-canonical functions.For example,it can localize to mitochondria under increased stress and protect cells in vitro from oxidative stress,DNA damage and apoptosis.Recently it has been demonstrated that TERT protein persists in adult neurons in the brain and data emerge suggesting that it might have a protective function in these post-mitotic cells as well.We have recently published that TERT protein accumulated in mitochondria from brain tissue of mice that have undergone short-term dietary restriction(DR) and rapamycin treatment.This localization correlated to lower levels of oxidative stress in these brain mitochondria.Since rapamycin treatment decreases mTOR signaling which is also thought to play an important role for the beneficial effects of DR,we conclude that the mTOR pathway might be involved in the TERT localization and its effects in brain mitochondria in vivo.These data are in line with previous findings from our group about increased mitochondrial localization of TERT in Alzheimer's disease(AD) brains and a protective function of TERT protein in neurons in vitro against pathological tau.	Satomi Miwa Gabriele Saretzki	2017	Neural Regeneration Research2017，12，3：	2
2	hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines 显示文摘	Saretzki G Petersen S Petersen I	2002	Cancer Lett2002，176，：	1
3	hTERT gene dosage correlates with telomerase activity in human lung cancer cell lines显示文摘	Saretzki G Petersen S Petersen I	2002	Cancer Lett2002，176，1：	1
4	Stochastic variation in telomere shortening rate causes heterogeneity of human fibroblast replicative life span 显示文摘	Martin -Ruiz C Saretzki G Petrie J	2004	J Biol Chem2004，279，17：	1
5	BJ fibroblasts display high antioxidant capacity and slow telomere shortening independent of hTERT transfection 显示文摘	Lorenz M Saretzki G Sitte N	2001	Free Radic Biol Med2001，31，6：	1
6	Telomerase, mitochondria and oxidative stress 显示文摘	Saretzki G	2009	Exp Gerontol2009，44，8：	1
7	hTERT gene dosage correlates with telomerease activeity in human lung cancer cell lines显示文摘	Saretzki G Petersen S Petersen I	2002	Cancer Letters2002，176，：	1
8	Human induced pluripotent stem cell lines show stress defense mechanisms and mitochondrial regulation similar to those of human embryonic stem cells显示文摘	Armstrong L Tilgner K Saretzki G		0，，：	1
9	Ribozyme- mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells 显示文摘	Saretzki G Ludwig A yon Zglinicki T	2001	Cancer Gene Ther2001，8，10：	1
10	Accelerated telomere shortening in fibroblasts after extended periods of confluency 显示文摘	Sitte N Saretzki G von Zglinicki T	1998	Free Radic Biol Med1998，24，6：	1
11	Telomerase inhibition as cancer t herapy显示文摘	Saretzki G	2003	Cancer Lett2003，194，2：	1
12	Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts: amodel for senescence显示文摘	Von Zglinicki T Saretzki G Docke W	1995	Exp Cell Res1995，220，1：	1
13	Human cell se- nescence as a DNA damage response 显示文摘	von Zglinicki T Saretzki G Ladhoff J	2005	Mech Ageing Dev2005，126，1：	1
14	Preferential accumulation of single-stranded regions in telomeres of human fibroblasts显示文摘	Petersen S Saretzki G von Zglinicki T	1998	Exp Cell Res1998，239，1：	1
15	Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial cells to inhibitors of topoisomerase显示文摘	Ludwig A Saretzki G Holm PS	2001	Cancer Res2001，61，：	1
16	Ribozyme-mediated telomerase inhibition induces immediate cell loss but not telomere shortening in ovarian cancer cells显示文摘	Saretzki G Ludwig A von Zglinicki T	2001	Cancer Gene Ther2001，8，：	1
17	Mild hyperoxia shortens telomeres and inhibits proliferation of fibroblasts:a model for senescence显示文摘	Saretzki G Docke W	1995	Exp Cell Res1995，220，1：	1
18	Downregulation of Multiple Stress Defense Mechanisms During Differentiation of Human Embryonic Stem Cells显示文摘	Gabriele Saretzki Theresia Walter Stuart Atkinson	2008	Stem Cells2008，26，：	1
19	Overexpression of telomerase confers growth advantage, stress resistance, and enhanced differentiation of ESCs toward thehematopoietic lineage显示文摘	Armstrong L Saretzki G Peters H	2005	Stem Cells2005，23，4：	1
20	Ribozyme cleavage of telomerase mRNA sensitizes breast epithelial celis to inhibitors of topoisomerase显示文摘	Ludwig A Saretzki G Holm PS	2001	Cancer Res2001，61，7：	1

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