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| 1 | AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint显示文摘 | Russell G. Jones David R. Plas Sara Kubek Monica Buzzai James Mu Yang Xu Morris J. Birnbaum Craig B. Thompson | 2005 | Molecular Cell2005，，3： | 3 |
| 2 | Toll‐Like Receptors and Cytokines are Upregulated during H elicobacter pylori Infection in Children显示文摘 | Hugo Lagunes‐Servin Javier Torres Carmen Maldonado‐Bernal Martha Pérez‐Rodríguez Sara Huerta‐Yépez Armando Madrazo de la Garza Leopoldo Mu?oz‐Pérez Lourdes Flores‐Luna Guillermo Ramón‐García Margarita Camorlinga‐Ponce | 2013 | Helicobacter2013，，6： | 2 |
| 3 | The insecticidal, molting disruption and insect growth inhibitory activity of extracts from Condalia microphylla Cav. (Rhamnaceae)显示文摘 | Carlos L. Cespedes Sofia C. Molina Evelyn Mu?oz Claudio Lamilla Julio Alarcon Sara M. Palacios Maria C. Carpinella Jose G. Avila | 2013 | Industrial Crops & Products2013，，： | 1 |
| 4 | COX-2 is involved in vascular oxidative stress and endothelial dysfunction of renal interlobar arteries from obese Zucker rats显示文摘 | Mercedes Mu?oz Ana Sánchez María Pilar Martínez Sara Benedito Maria-Elvira López-Oliva Albino García-Sacristán Medardo Hernández Dolores Prieto | 2015 | Free Radical Biology and Medicine2015，，： | 1 |
| 5 | AMP-Activated Protein Kinase Induces a p53-Dependent Metabolic Checkpoint显示文摘 | Russell G. Jones David R. Plas Sara Kubek Monica Buzzai James Mu Yang Xu Morris J. Birnbaum Craig B. Thompson | 2005 | Molecular Cell2005，，3： | 1 |
| 6 | Nitrogen remote diagnosis in a creeping bentgrass golf green显示文摘 | Rafael J. López-Bellido Luis López-Bellido Purificación Fernández-García Juan M. López-Bellido Verónica Mu?oz-Romero Pedro J. López-Bellido Sara Calvache | 2011 | European Journal of Agronomy2011，，1： | 1 |
| 7 | Impact of common gastrointestinal disorders in elderly on in vitro meat protein digestibility and related properties显示文摘This study aimed to in vitro evaluate the impact of common gastrointestinal(GI)alterations appearing with aging on protein digestibility,and functional related properties,in four different meats(chicken,turkey,pork and beef).Thus,three elderly digestion models were stated as long as altered GI conditions affected at oral(E1),oral and gastric(E2)and oral,gastric and intestinal stages(E3).Healthy adult GI conditions were also mimicked as standard control model(C).A notable trichloroacetic acid(TCA)soluble protein and the free amino acids(FAA)release reduction(p<0.05)were found under intestinal suboptimal conditions(E3),being more accused in beef than in other meats.Thus,chicken intake would be more advisable,than other meats,in terms of protein digestibility;while beef would provide a greater net supply of FAA under E3 model conditions.Gastric altered conditions,seem to favor protein solubility.Finally,while gastric and intestinal suboptimal conditions diminish the angiotensin converting enzyme(ACE)inhibition of meat digesta,their antioxidant activity was only negatively affected by intestinal altered conditions. | Ever Hern´andez-Olivas Sara Mu˜noz-Pina Jorge García-Hern´andez Ana Andr´es Ana Heredia | 2022 | Food Bioscience2022，46，2： | 0 |
| 8 | 环境税收对墨西哥杀虫剂的影响显示文摘一种最理想的杀虫剂税将按照毒性程度对市场销售的物质加以区分.在墨西哥采取这一税收是准备将来扩展按照国际协议逐步淘汰并最终消除的杀虫剂名单的最有效的方法.本文分析了三种不同的环境征税方案的内涵:对所有的杀虫剂普遍征税15%(弥补目前免征增值税的状况);根据毒性分别征税15%、10%、5%或者0%;对现在经审定的毒性最大的物质征税10%.税收必须用于恢复人类和生态系统健康以及赔付其他类型的损害. | Carlos Muoz Pia Sara Avila Forcada 蔡学娣 | 2005 | 产业与环境2005，27，2： | 0 |
| 9 | 环境税收对墨西哥杀虫剂的影响显示文摘一种最理想的杀虫剂税将按照毒性程度对市场销售的物质加以区分.在墨西哥采取这一税收是准备将来扩展按照国际协议逐步淘汰并最终消除的杀虫剂名单的最有效的方法.本文分析了三种不同的环境征税方案的内涵;对所有的杀虫剂普遍征税15%(弥补目前免征增值税的状况);根据毒性分别征税15%、10%、5%或者0%;对现在经审定的毒性最大的物质征税10%.税收必须用于恢复人类和生态系统健康以及赔付其他类型的损害. | Carlos Mu(n)oz Pi(n)a Sara Avila Forcada 蔡学娣 | 2005 | 生态毒理学报2005，，2： | 0 |
| 10 | CRISPR/Cas9 editing of the polygalacturonase FaPG1 gene improves strawberry fruit firmness显示文摘Firmness is one of the most important fruit quality traits in strawberries.The postharvest shelf life of this soft fruit is highly limited by the loss of firmness,where cell wall disassembly plays an important role.Previous studies demonstrated that the polygalacturonase FaPG1 has a key role in remodelling pectins during strawberry softening.In this study,FaPG1 knockout strawberry plants have been generated using the CRISPR/Cas9 system delivered via Agrobacterium tumefaciens.Ten independent lines,cv.“Chandler”,were obtained,and all of them were successfully edited as determined by PCR amplification and T7 endonuclease assay.The targeted mutagenesis insertion and deletion rates were analyzed using targeted deep sequencing.The percentage of edited sequences varied from 47%up to almost 100%,being higher than 95%for seven of the selected lines.Phenotypic analyses showed that 7 out of the eight lines analyzed produced fruits significantly firmer than the control,ranging from 33 to 70%increase in firmness.There was a positive relationship between the degree of FaPG1 editing and the rise in fruit firmness.Minor changes were observed in other fruit quality traits,such as colour,soluble solids,titratable acidity or anthocyanin content.Edited fruits showed a reduced softening rate during postharvest,displayed a reduced transpirational water loss,and were less damaged by Botrytis cinerea inoculation.The analysis of four potential off-target sites revealed no mutation events.In conclusion,editing the FaPG1 gene using the CRISPR/Cas9 system is an efficient method for improving strawberry fruit firmness and shelf life. | Gloria López-Casado Cristina Sánchez-Raya Pablo D.Ric-Varas Candelas Paniagua Rosario Blanco-Portales Juan Muñoz-Blanco Sara Pose Antonio J.Matas Jose A.Mercado | 2023 | Horticulture Research2023，10，3： | 0 |
| 11 | Antibody and T cell responses against wild-type and Omicron SARS-CoV-2 after third-dose BNT162b2 in adolescents显示文摘The high effectiveness of the third dose of BNT162b2 in healthy adolescents against Omicron BA.1 has been reported in some studies,but immune responses conferring this protection are not yet elucidated.In this analysis,our study(NCT04800133)aims to evaluate the humoral and cellular responses against wild-type and Omicron(BA.1,BA.2 and/or BA.5)SARS-CoV-2 before and after a third dose of BNT162b2 in healthy adolescents.At 5 months after 2 doses,S IgG,S IgG Fc receptor-binding,and neutralising antibody responses waned significantly,yet neutralising antibodies remained detectable in all tested adolescents and S IgG avidity increased from 1 month after 2 doses.The antibody responses and S-specific IFN-γ^(+)and IL-2^(+)CD8^(+)T cell responses were significantly boosted in healthy adolescents after a homologous third dose of BNT162b2.Compared to adults,humoral responses for the third dose were non-inferior or superior in adolescents.The S-specific IFN-γ^(+)and IL-2^(+)CD4^(+)and CD8^(+)T cell responses in adolescents and adults were comparable or non-inferior.Interestingly,after 3 doses,adolescents had preserved S IgG,S IgG avidity,S IgG FcγRIIIa-binding,against Omicron BA.2,as well as preserved cellular responses against BA.1 S and moderate neutralisation levels against BA.1,BA.2 and BA.5.Sera from 100 and 96%of adolescents tested at 1 and 5 months after two doses could also neutralise BA.1.Our study found high antibody and T cell responses,including potent cross-variant reactivity,after three doses of BNT162b2 vaccine in adolescents in its current formulation,suggesting that current vaccines can be protective against symptomatic Omicron disease. | Xiaofeng Mu Carolyn A.Cohen Daniel Leung Jaime S.Rosa Duque Samuel M.S.Cheng Yuet Chung Howard H.W.Wong Amos M.T.Lee Wing Yan Li Issan Y.S.Tam Jennifer H.Y.Lam Derek H.L.Lee Sau Man Chan Leo C.H.Tsang Karl C.K.Chan John K.C.Li Leo L.H.Luk Sara Chaothai Kelvin K.H.Kwan Nym Coco Chu Masashi Mori Trushar Jeevan Ahmed Kandeil Richard JWebby Wenwei Tu Sophie A.Valkenburg Malik Peiris Yu Lung Lau | 2023 | Signal Transduction and Targeted Therapy2023，8，1： | 0 |
| 12 | Insight on BRAF^(V600E)mutated colorectal cancer immune microenvironment显示文摘Colorectal cancer(CRC)is the second deadliest malignancy for both sexes.The BRAF^(V600E)mutation,one of the most common driver mutations in CRC,is known for its poor prognosis due to the increased risk of metastasis.The effect of the BRAF^(V600E)mutation on the tumor microenvironment was the topic of the study reported in World Journal of Gastrointestinal Oncology,with special focus on immune status.The authors presented insightful findings that were exclusively based on macrophage polarity and cytokine levels,without investigating other relevant immune elements.A more comprehensive look into the dynamic immune activity of cancer environments will warrant more meaningful practical findings.In this letter,we discuss other significant immune factors and their possible implications on the tumor microenvironment of BRAF-mutated CRC. | Hassan Mohammed Abushukair Sara Mu'amar Zaitoun Anwaar Saeed | 2022 | World Journal of Gastrointestinal Oncology2022，14，6： | 0 |
| 13 | DLST mutations in pheochromocytoma and paraganglioma cause proteome hyposuccinylation andmetabolic remodeling显示文摘Dear Editor,Of all human tumors,pheochromocytomas and paragangliomas(PPGLs)have the highest heritability rate.Over 15%of PPGLs harbor mutations in genes encoding tricarboxylic acid(TCA)cycle-related enzymes that cause oncometabolite accumulation and drive tumorigenesis via metabolic adaptation to hypoxia and global hypermethylation[1].The dihydrolipoamide S-succinyltransferase(DLST)gene was recently described as a new PPGL susceptibility gene[2]. | Sara Mellid Fernando García Luis Javier Leandro-García Alberto Díaz-Talavera Ángel Mario Martínez-Montes Eduardo Gil Bruna Calsina María Monteagudo Rocío Letón Juan María Roldán-Romero María Santos Javier Lanillos Carlos Valdivia Natalia Martínez-Puente Javier de Nicolás-Hernández Scherezade Jiménez Manuel Pérez-Martínez Emiliano Honrado Javier Coloma Ana Cerezo Clara María Santiveri Manel Esteller Ramón Campos-Olivas Eduardo Caleiras Cristina Montero-Conde Cristina Rodríguez-Antona Javier Muñoz Mercedes Robledo Alberto Cascón | 2023 | Cancer Communications2023，43，7： | 0 |
| 14 | Systemic Inflammation Response Index and weight loss as prognostic factors in metastatic pancreatic cancer: A concept study from the PANTHEIA-SEOM trial显示文摘BACKGROUND The prognostic value of the Systemic Inflammation Response Index(SIRI)in advanced pancreatic cancer is recognized,but its correlation with patients´nutritional status and outcomes remains unexplored.AIM To study the prognostic significance of SIRI and weight loss in metastatic pancreatic cancer.METHODS The PANTHEIA-Spanish Society of Medical Oncology(SEOM)study is a multicentric(16 Spanish hospitals),observational,longitudinal,non-interventional initiative,promoted by the SEOM Real World-Evidence work group.This pilot study sought to analyze the association between weight loss and inflammatory status as defined by SIRI.The cohort stems from a proof-of-concept pilot study conducted at one of the coordinating centers.Patients with pathologically confirmed metastatic pancreatic adenocarcinoma,treated from January 2020 to January 2023,were included.The index was calculated using the product of neutrophil and monocyte counts,divided by lymphocyte counts,obtained within 15 days before initiation chemotherapy.This study evaluated associations between overall survival(OS),SIRI and weight loss.RESULTS A total of 50 patients were included.66%of these patients were male and the median age was 66 years.Metastasis sites:36%liver,12%peritoneal carcinomatosis,10%lung,and 42%multiple locations.Regarding the first line palliative chemotherapy treatments:50%received gemcitabine plus nab-paclitaxel;28%,modified fluorouracil,leucovorin,irinotecan and oxaliplatin,and 16%were administered gemcitabine.42%had a weight loss>5%in the three months(mo)preceding diagnosis.21 patients with a SIRI≥2.3×10^(3)/L exhibited a trend towards a lower median OS compared to those with a SIRI<2.3×10^(3)/L(4 vs 18 mo;P<0.000).Among 21 patients with>5%weight loss before diagnosis,the median OS was 6 mo,in contrast to 19 mo for those who did not experience such weight loss(P=0.003).Patients with a weight loss>5%showed higher SIRI levels.This difference was statistically significant(P<0.000).For patients with a SIRI<2.3×10^(3)/L,those who did not lose>5%of their weight had an OS of 20 mo,compared to 11 mo for those who did(P<0.001).No association was found between carbohydrate antigen 19-9 levels≥1000 U/mL and weight loss.CONCLUSION A higher SIRI was correlated with decreased survival rates in patients with metastatic pancreatic cancer and associated with weight loss.An elevated SIRI is suggested as a predictor of survival,emphasizing the need for prospective validation in the upcoming PANTHEIA-SEOM study. | Vilma Pacheco-Barcia Sara Custodio-Cabello Fatima Carrasco-Valero Magda Palka-Kotlowska Axel Mariño-Mendez Alberto Carmona-Bayonas Javier Gallego A J Muñoz Martín Paula Jimenez-Fonseca Luis Cabezon-Gutierrez | 2024 | World Journal of Gastrointestinal Oncology2024，16，2： | 0 |
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