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| 1 | Epidemiological Evolution of Lung Cancer in the South of Spain from 1990 to 2010显示文摘Background: Changes in lung cancer has been characterized by the increase of cases among women and the increase in adenocarcinomas among other histological subtypes.Methods: Descriptive analysis of cases diagnosed with lung cancer in Hospital Virgen de las Nieves(Spain) from 1990 to 2010,based on five variables(age, sex, smoking, histology and pathological anatomy). The study establishes associations between these variables and compares the results with the literature.Results: 2,026 patients were diagnosed with lung cancer in this period; 1,838 were males(90.7%) and 188 women(9.3%); 1,892 patients(93.4%) were smokers or ex-smokers and 134(6.6%) had never smoked; the most frequent non-small cell histology types were squamous cell carcinoma and adenocarcinoma and it was the most frequent neoplasia in women and were associated with a lower tobacco consumption.Conclusion: The large majority of lung cancer cases is associated with a history of smoking tobacco and there are histopathological differences according to gender and cumulative tobacco smoke load. | Alberto Caballero Vázquez Ana Dolores Romero Ortiz Jose Manuel González de Vega San Román Raimundo García del Moral Bernardino Alcázar Navarrete | 2018 | 中国肺癌杂志2018，21，1： | 17 |
| 2 | Are we giving azathioprine too late? The case for early immunomodulation in inflammatory bowel disease显示文摘Inflammatory bowel disease (IBD) includes two entities, Crohn’s disease and ulcerative colitis. Both are chronic conditions with frequent complications and surgical procedures and a great impact on patient’s quality of life. The thiopurine antimetabolites azathioprine and 6-mercaptopurine are widely used in IBD patients. Current indications include maintenance therapy, steroid-dependant disease, fistula closure, prevention of infliximab immunogenicity and prevention of Crohn’s disease recurrence. Surprisingly, the wide use of immunosuppressants in the last decades has not decreased the need of surgery, probably because these treatments are introduced at too late stages in disease course. An earlier use of immunossupressants is now advocated by some authors. The rational includes: (1) failure to modify IBD natural history of present therapeutic approach, (2) demonstration that azathioprine can induce mucosal healing, a relevant prognostic factor for Crohn’s disease and ulcerative colitis, and (3) demonstration that early immunossupression has a very positive impact on pediatric, recently diagnosed Crohn’s disease patients. We are now awaiting the results of new studies, to clarify the contribution of azathioprine, as compared to infliximab (SONIC Study), and to demonstrate the usefulness of azathioprine in recently diagnosed adult Crohn’s disease patients (AZTEC study). | María Josefina Etchevers Montserrat Aceituno Miquel Sans | 2008 | World Journal of Gastroenterology2008，14，36： | 10 |
| 3 | 经皮经导管射频消融去肾交感神经术与螺内酯对难治性高血压昼夜节律和血压变异性的影响显示文摘经皮经导管射频消融去肾交感神经术(sympathetic renal denervation,SRD)可作为药物控制不佳的难治性高血压患者的一种替代治疗方法,SRD对减少短期血压变异性(blood pressure variability,BPV)有效。然而,这个作用尚未在随机对照试验中证实。本研究旨在比较螺内酯和SRD对昼夜血压和BPV的影响。方法:对一项随机试验进行析因分析, | de la Sierra A Pareja J Armario P Barrera Yun S Vázquez S Sans L Pascual J Oliveras A 陈云 叶鹏 | 2017 | 中华高血压杂志2017，25，8： | 3 |
| 4 | Can testosterone therapy be offered to men on active surveillance for prostate cancer? Preliminary results显示文摘这份报告在活跃监视上在 T 缺乏的人的一个队与 T 治疗介绍我们的经验(作为) 为 Gleason 3 + 3 并且 Gleason 3 + 4 前列腺癌症(PCa ) 。回顾的图表评论与 T 缺乏识别了 28 个人经历 T 治疗(T 组) 至少 6 个月了当时在上至于 PCa。96 个人在上的一个比较组至于有未经治疗的 T 缺乏的 PCa (别组织) 在一样的机构被识别。同样协议跟随了修改爱泼斯坦标准和有小量的 Gleason 3 + 的一个单个核心的人的允许的包括 4 PCa。吝啬的年龄是 59.5 和 61.3 年,并且意味着后续是为 T 的 38.9 和 42.4 个月并且不分别地组织。在 T 组的所有 28 个人, 3 (10.7%) 人们在格利森分数开发了增加当时在上作为。22,在 T 的人与 Gleason 3 + 组织 3 疾病, 7 (31.8%) 人们包括开发了 Gleason 3 + 的 3 个人(13.6%) 开发了活体检视前进 4 PCa。有 Gleason 3 + 的 6 个人在基线的 4 疾病, 2 (33.3%) 人们在肿瘤体积开发了增加,并且任何一个都没发展在 Gleason 3 + 以外升级 4。所有 96 个人在别组织有的 Gleason 3 + 在基线的 3 疾病并且,(44.7%) 43 开发了活体检视前进,包括有升级到 Gleason 7 的 9 个人(9.38%)(3 + 4 ) 。活体检视前进率为组和历史的控制是类似的。在人在上的活体检视前进作为在 3 年由 T 治疗显得未受影响。在 T 缺乏的人在上的 T 治疗的未来的控制安慰剂的试用作为应该被认为给对待的人经验丰富的征兆的好处。 | Ravi Kacker Mariam Hult Ignacio F San Francisco William P Conners Pablo A Rojas William C Dewolf Abraham Morgentaler | 2016 | Asian Journal of Andrology2016，18，1： | 2 |
| 5 | Influence of antiviral therapy in the long‐term outcome of recurrent hepatitis C virus infection following liver transplantation显示文摘 | A. García‐Reyne C. Lumbreras I. Fernández F. Colina M. Abradelo P. Magan R. San‐Juan A. Manrique F. López‐Medrano A. Fuertes M. Lizasoain E. Moreno J.M. Aguado | 2013 | Transpl Infect Dis2013，，4： | 2 |
| 6 | Photocatalytic degradation of 4-nitrophenol in aqueous TiO2 suspensions: Theoretical prediction of the intermediates 显示文摘 | San N Hatipoglu A | 2002 | J Photochem Photobiol A2002，146，： | 1 |
| 7 | Metabolic engineering of Escherichia coli to enhance recombinant protein production through acetate reduction显示文摘 | Aristidou A A San K Y Bennett G N | 1995 | Biotechnol Prog1995，11，： | 1 |
| 8 | Enhanced plasmid maintenance in a CSRT upon square-wave oscillations in the dilution rate显示文摘 | Weber A E San K Y | 1988 | Biotechnology Letters1988，10，8： | 1 |
| 9 | Biogenic amines in wines: influence of oenological factors显示文摘 | MARQUES A P LEITAO M C SAN ROMAO M V | 2008 | Food Chemistry2008，107，2： | 1 |
| 10 | Congenital nasolacrimal duct occlusion with clinical anophthalmos:a possible new as- sociation显示文摘 | Oguz H Ozturk A San I | 2003 | Ophthalmic Genet2003，24，3： | 1 |
| 11 | Biochemistry, Physiology, and Pathophysiology of NADPH Oxidases in the Cardiovascular Sys- tem显示文摘 | Lassegue B San Martin A Griendling KK | 2012 | Circ Res2012，110，2： | 1 |
| 12 | Chlorophyllase and quality of 'Granny Smith' apples during storage 显示文摘 | IhI M A San Martin V Bifani | 2000 | Garten- bauwissenschaft2000，65，6： | 1 |
| 13 | Improving classification per-formance of Support Vector Machine by genetically optimizing ker-nel shape and hyper - parameters 显示文摘 | San L D Rogozan A Pecuchet J P | 2010 | Applied Intelligence2010，36，2： | 1 |
| 14 | Relapse and therapeutic in-terventions in a 1-year observational cohort study of nonadher-ent outpatients with schizophrenia显示文摘 | Ciudad A San L Bernardo M | | 0，，02： | 1 |
| 15 | Low amounts and high thiol oxidation of peroxiredoxins in spermatozoa from infertile men显示文摘 | Gong S San Gabriel MC Zini A | 2012 | J Androl2012，33，： | 1 |
| 16 | Small-plasmid-mediated antibiotic resistance is enhanced by increases inplasmid copy number and bacterial fitness 显示文摘 | San Millan A Santos-Lopez A Ortega-Huedo R | | Antimicrobial0，，： | 1 |
| 17 | The grafting of triploid watermelon is an advantageous alternative to soil fumigation by methyl bromide for control of Fusarium wilt 显示文摘 | Miguel A Maroto J V San Bautista A | 2004 | Scientia Horticulturae2004，103，： | 1 |
| 18 | Diagnosing tuberculous pleu- ral effusion using clinical data and pleural fluid analysis:A study of patients less than 40 years - old in an area with a high incidence of tuberculosis显示文摘 | Valdes L San Jose ME Pose A | 2010 | Respir Med2010，104，8： | 1 |
| 19 | Control of Arabidopsis meristem developraent by thioredoxin dependent regulation of intercellular transport显示文摘 | BENITEZ-ALFONSO Y CILLIA M SAN ROMAN A | 2009 | Proceedings of the National Academy of Sciences2009，106，9： | 1 |
| 20 | 显示文摘 | de Lima A L Mbengue A San Gil R A S | 2014 | Catalysis Today2014，226，： | 1 |
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