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| 1 | Predictors of mortality after transjugular portosystemic shunt显示文摘AIM:To investigate if echocardiographic and hemodynamic determinations obtained at the time of transjugular intrahepatic portosystemic shunt(TIPS)can provide prognostic information that will enhance risk stratification of patients.METHODS:We reviewed medical records of 467 patients who underwent TIPS between July 2003 and December 2011 at our institution.We recorded information regarding patient demographics,underlying liver disease,indication for TIPS,baseline laboratory values,hemodynamic determinations at the time of TIPS,and echocardiographic measurements both before and after TIPS.We recorded patient comorbidities that may affect hemodynamic and echocardiographic determinations.We also calculated Model for Endstage Liver Disease(MELD)score and Child Turcotte Pugh(CTP)class.The following pre-and post-TIPS echocardiographic determinations were recorded:Left ventricular ejection fraction,right ventricular(RV)systolic pressure,subjective RV dilation,and subjective RV function.We recorded the following hemodynamic measurements:Right atrial(RA)pressure before and after TIPS,inferior vena cava pressure before and after TIPS,free hepatic vein pressure,portal vein pressure before and after TIPS,and hepatic venous pressure gradient(HVPG).RESULTS:We reviewed 418 patients with portal hypertension undergoing TIPS.RA pressure increased by a mean ± SD of 4.8 ± 3.9 mmH g(P < 0.001),HVPG decreased by 6.8 ± 3.5 mmH g(P < 0.001).In multivariate linear regression analysis,a higher MELD score,lower platelet count,splenectomy and a higher portal vein pressure were independent predictors of higher RA pressure(R = 0.55).Three variables predicted 3-mo mortality after TIPS in a multivariate analysis:Age,MELD score,and CTP grade C.Change in the RA pressure after TIPS predicted long-term mortality(per 1 mm Hg change,HR = 1.03,95%CI:1.01-1.06,P < 0.012).CONCLUSION:RA pressure increased immediately after TIPS particularly in patients with worse liver function,portal hypertension,emergent TIPS placement and history of splenectomy.The increase in RA pressure after TIPS was associated with increased mortality.Age,splenectomy,MELD score and CTP grade were independent predictors of long-term mortality after TIPS. | Mona Ascha Sami Abuqayyas Ibrahim Hanouneh Laith Alkukhun Mark Sands Raed A Dweik Adriano R Tonelli | 2016 | World Journal of Hepatology2016，8，11： | 13 |
| 2 | Monomethyl fumarate augments NK cell lysis of tumor cells through degranulation and the upregulation of NKp46 and CDIO7a显示文摘Dimethyl fumarate (DMF ) 是使用到对待的新药多重硬化(MS ) 病人。这里,我们在生来的杀手(NK ) 的各种各样的活动检验了 DMF 和 DMF 代谢物 monomethyl fumarate (MMF ) 的效果房间。我们证明 MMF 扩充 K562 和 RAJI 肿瘤房间的主要 CD56 +, 然而并非 CD56 −, NK 房间细胞溶解。MMF 为 24 h 在孵化以后在 CD56 +, 然而并非 CD56 −, NK 房间的表面上导致了 NKp46 表示。这效果密切通过这代谢物从这些房间在 CD56 + NK 房间和 Granzyme B 版本的正式就职的表面上与 CD107a 表示的 upregulation 被相关。anti-NKp46 抗体通过 CD56 + NK 房间禁止了 CD107a 的导致 MMF 的 upregulation 和肿瘤房间的细胞溶解。因此,这些结果是第一证明 MMF 扩充肿瘤目标房间的 CD56 + NK 房间细胞溶解,效果通过 NKp46 调停了。这新奇效果在癌症为治疗学或预防的协议建议 MMF 的使用。 | Heidi Vego Kristin L Sand Rune A Hoglund Lars-Egil Fallang Glenn Gundersen Trygve Holmoy Azzam A Maghazachi | 2016 | Cellular & Molecular Immunology2016，13，1： | 2 |
| 3 | The isothermal austenite-ferrite transformation in some deformed vanadium steels显示文摘 | M J Crooks A J Garratt-Reed J B Vander Sande W S Owen | 1982 | Metallurgical Transactions A1982，，8： | 2 |
| 4 | The Time Dimension and Lithium Resource Constraints for Electric Vehicles 显示文摘 | Kushnir D Sand~n B A | 2012 | Resources Policy2012，37，1： | 1 |
| 5 | Morphological phy- logenetics of termites (Isoptera) 显示文摘 | Donovan S E Jones D T Sands W A | 2000 | Biological Journal of the Linnean Society2000，70，3： | 1 |
| 6 | Synthesis and characterizationof alginate-g-vinyl sulfonic acid with a potassium peroxydiphosphate/thiourea system显示文摘 | Sand A Yadav M Behari K | 2010 | Journal of Applied PolymerScience2010，118，6： | 1 |
| 7 | Regional Clusters in AGlobal Industry : ICT Clusters in Canada 显示文摘 | Lucas M Sands A Wolfe D A | 2009 | EuropeanPlanning Studies2009，17，2： | 1 |
| 8 | New genera and species of soil feeding termites (Isoptera: Termitidae ) from African savannas 显示文摘 | Sands W A | 1995 | Journal of Natural History1995，29，6： | 1 |
| 9 | Progress in bioleaching: Fundamentals and mechanisms of bacterial metal sulfide oxidation-Part A 显示文摘 | VERA M SCHIPPERS A SAND W | 2013 | Applied Microbiology and Biotechnology2013，97，17： | 1 |
| 10 | Radicals and Morita Contexts显示文摘 | Sands A D | 1973 | Algebra1973，24，： | 1 |
| 11 | Evaluation of CHROMagar Candida for Presumptive Identification of Clinically Important Candida Species显示文摘 | Heather L Powell Crystal A Sand Robert P Rennie | 1998 | Diagn Microbiol Infect Dis1998，32，4： | 1 |
| 12 | Psychological stress perturbs epidermal permeability barrier homeostasis: Implications for the pathogenesis of stress - associated skin disorders 显示文摘 | Garg A Chren MM Sands LP | 2001 | Arch Dermatol2001，137，1： | 1 |
| 13 | Sulfur chemistry in bacterial of pyrite显示文摘 | SCHIPPERS A JOZSA P G SAND W | | 0，，09： | 1 |
| 14 | Characterisation of alkaloids from some Australian Stephania (Menisperma-ceae)species 显示文摘 | Blanchfield JT Sands DP A Kennard CHL | 2003 | Phytochemistry2003，63，6： | 1 |
| 15 | Bacterial leaching of metal sulfides proceeds by the indirect mechanisms via thiosulfate or via polysulfides and sulfur 显示文摘 | SCHIPPERS A SAND W | 1999 | Appl Environ Microbiol1999，65，1： | 1 |
| 16 | Lisfranc injuries 显示文摘 | Sands AK Grose A | 2004 | Injury2004，35，2： | 1 |
| 17 | Microflora of four fermented fish sauces显示文摘 | CRISAN E V SANDS A | 1975 | Applied Microbiology1975，29，1： | 1 |
| 18 | Embryonic stem cells and therapeutic cloning显示文摘 | Eftedal I | 2001 | Tidsskr Nor Laegeforen2001，121，20： | 1 |
| 19 | Prospective,randomized,double-blind study of the efficacy and tolerability of the extended-release formulations of oxybutynin and tolterodine for overactive bladder; results of the OPERA trial显示文摘 | Diokno A C Apell R A Sand P K | 2003 | Mayo Clin Proc2003，78，4： | 1 |
| 20 | Formulation and characterisation of primaquine loaded liposomes prepared by a pH gradient using experimental design显示文摘 | STENSRUD G SANDE S A KRISTENSEN S | 2000 | Inter J Pharm2000，198，2： | 1 |
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