| 1 | Synthesis of highly fluorescent and water soluble perylene bisimide显示文摘设计并且综合一新高度浇可溶的 N, N 二度(2-((5-((dimethylamino ) 甲基) furan-2-yl ) methylthio ) 乙醇) 从 2- 的 perylene-3,4,9,10-tetracarboxylic diimide ((5-((dimethylamino ) 甲基) furan-2-yl ) methylthio ) ethanamine 和 perylene-3,4,9,10-tetracarboxylic dianhydride。混合物被 1H, 13C, 2D NMR,团和红外技术描绘。混合物与水和另外的极的溶剂里的好溶解度是高度荧光灯的。 | Gopal Boobalan Predhanekar Mohamed Imran Samuthira Nagarajan | 2012 | Chinese Chemical Letters2012，23，2： | 3 |
| 2 | Antiproliferative effect of silver nanoparticles synthesized using amla on Hep2 cell line显示文摘Objective:To synthesize silver nanoparticles by amla extract,screen the cytotoxic,oxidative stress and apoptotic effect of silver nanoparticles(AgNPs) on Hep2 cell line(laryngeal carcinoma cells) in vitro,and to compare the effect of Phyllanthm emblica(P.emblica)(amla) with AgNPs synthesized by amla and 5-FU.Methods:AgNPs was synthesized by P.emblica(aqueous extract) and nanoparticles were characterized UV-Vis spec,the presence of biomoloecules of amla capped in AgNPs was found by FT-IR analysis,shape and size were examined by SEM and DLS.Cytotoxicity of experimental drugs was tested to find IC50 value.ROS generation in cells have been measured by DCFH-DA staining.AO-EtBr,Rhodamine-123 staining and DNA fragmentation were performed to assess apoptotic cell death,mitochondrial membrane potential and apoptotic DNA damage,respectively.Oxidative stress was analyzed by measuring lipid peroxides and antioxidants level lo understand the cancer cell death by pro-oxidant mechanism. Results:PE-AgNPs was synthesized and confirmed through kinetic behavior of NPs.The shape of PE-AgNPs was spherical and cubic since it was agglomerated,and the nanoparticle surface was complicated.Average particle size distribution of PE-AgNPs was found to be 188 nm.Potent biomolecules of P.emblica such as polyphenols were capped with AgNPs and reduced its toxicity. In cytotoxicity assay the concentration in which the maximum number of cell death was 60μg/mL and 50μg/mL for P.emblica(alone) and AgNPs,respectively and IC50 values were fixed as 30μg/mL and 20μg/mL.ROS generation,apoptotic morphological changes,mitochondrial depolarization.DNA damage and oxidative stress was observed as more in AgNPs treated cells than in P.emblica(30μg/mL)(alone) treated cells and 5-FU treated cells gave similar result. Conclusions:The results suggest that the AgNPs are capped with biomolecules of amla enhanced cytotoxicity in laryngeal cancer cells through oxidative stress and apoptotic function on Hep2 cancer cells. | Fathima Stanley Rosarin Vadivel Arulmozhi Samuthira Nagarajan Sankaran Mirunalini | 2013 | Asian Pacific Journal of Tropical Medicine2013，6，1： | 0 |
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