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| 1 | L-asparaginase production by mangrove derived Bacillus cereus MAB5:optimization by response surface methodology显示文摘Objective:To isolate marine bacteria,statistically optimize them for maximum asparaginase production.Methods:In the present study,statistically based experimental designs were applied to maximize the production of L-asparaginase from bacterial strain of Bacillus cereus(B.cereus) MAB5(HQ675025) isolated and identified by 16S rDNA sequencing from mangroves rhizosphere sediment.Results:Plackett-Barman design was used to identify the interactive effect of the eight variables viz.yeast extract,soyabean meal,glucose,magnesium sulphate,KH2PO4,wood chips,aspargine and sodium chloride.All the variables are denoted as numerical factors and investigated at two widely spaced intervals designated as -1(low level) and +1(high level). The effect of individual parameters on L-asparaginase production was calculated.Soyabean meal,aspargine,wood chips and sodium chloride were found to be the significant among eight variables.The maximum amount of L-asparaginase produced(51.54 IU/mL) from the optimized medium containing soyabean meal(6.282 8 g/L),aspargine(5.5 g/L),wood chips(1.383 8 g/L) and NaCl(4.535 4 g/L).Conclusions:The study revealed that,it is useful to produce the maximum amount of L-asparaginase from B.cereus MAB5 for the treatment of various infections and diseases. | Thenmozhi C Sankar R Karuppiah V Sampathkumar P | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 2 |
| 2 | Acute interstitial nephritis due to proton pump inhibitors显示文摘 | Sampathkumar K Ramalingam R Prabakar A | 2013 | Indian J Nephrol2013，23，4： | 1 |
| 3 | Is insulin signa- ling molecules misguided in diabetes for ubiquitin-proteasome me- diated degradation? 显示文摘 | Balasubramanyam M Sampathkumar R Mohan V | 2005 | Mol Cell Biochem2005，275，12： | 1 |
| 4 | Extended release nicotinic acid-a novel oral agent for phosphate control显示文摘 | Sampathkumar K Selvam M Sooraj Y S Gowt haman S Ajeshkumar R N | 2006 | Int Urol Nephrol2006，38，： | 1 |
| 5 | Norwe- gian scabies in a renal transplant patient显示文摘 | Sampathkumar K Mahaldar A R Ramakrishnan M | 2010 | Indian J Nephrol2010，20，2： | 1 |
| 6 | Risk prediction of acute kidney injury in car- diac surgery and prevention using aminophylline 显示文摘 | MAHALDAR A R SAMPATHKUMAR K RAGHURAM AR | 2012 | In- din J Nephrol2012，22，： | 1 |
| 7 | Glutamine fructose-6-phosphate amidotransferase (GFAT) gene expression and activity in patients with type 2 diabetes:inter-relationships with hyperglycaemia and oxidative stress显示文摘 | Srinivasan V Sandhya N Sampathkumar R | 2007 | Clin Biocherr2007，40，1314： | 1 |
| 8 | Emphysematous prostatitis in renal transplant显示文摘 | SAMPATHKUMAR K MURALI T R SOORAJ Y S | 2007 | Indi- an J Urol2007，23，4： | 1 |
| 9 | A potential lole for angiopoietin 2 in the regulation of the blood-retinal barrier in diabetic retinopathy 显示文摘 | Sampathkumar R Ramprasad S | 2011 | Invest Ophthalmol Vis Sci2011，52，6： | 1 |
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