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| 1 | L-asparaginase production by mangrove derived Bacillus cereus MAB5:optimization by response surface methodology显示文摘Objective:To isolate marine bacteria,statistically optimize them for maximum asparaginase production.Methods:In the present study,statistically based experimental designs were applied to maximize the production of L-asparaginase from bacterial strain of Bacillus cereus(B.cereus) MAB5(HQ675025) isolated and identified by 16S rDNA sequencing from mangroves rhizosphere sediment.Results:Plackett-Barman design was used to identify the interactive effect of the eight variables viz.yeast extract,soyabean meal,glucose,magnesium sulphate,KH2PO4,wood chips,aspargine and sodium chloride.All the variables are denoted as numerical factors and investigated at two widely spaced intervals designated as -1(low level) and +1(high level). The effect of individual parameters on L-asparaginase production was calculated.Soyabean meal,aspargine,wood chips and sodium chloride were found to be the significant among eight variables.The maximum amount of L-asparaginase produced(51.54 IU/mL) from the optimized medium containing soyabean meal(6.282 8 g/L),aspargine(5.5 g/L),wood chips(1.383 8 g/L) and NaCl(4.535 4 g/L).Conclusions:The study revealed that,it is useful to produce the maximum amount of L-asparaginase from B.cereus MAB5 for the treatment of various infections and diseases. | Thenmozhi C Sankar R Karuppiah V Sampathkumar P | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，6： | 2 |
| 2 | Herpes zoster (shingles) and postherpetic neuralgia显示文摘 | Sampathkumar P Drage L A Martin D P | 2009 | M ayo Clin Proc2009，84，： | 1 |
| 3 | Utilization of solar water heater in a single basin solar still-An experimental study 显示文摘 | Sampathkumar K Senthilkumar P | 2012 | Desalination2012，297，： | 1 |
| 4 | Herpes zoster (shingles) and postherpetic neuralgia显示文摘 | Sampathkumar P Drage L A Martin D P | 2009 | Mayo Clin Proc2009，84，3： | 1 |
| 5 | Herpes zoster ( shingles ) and postherpetic neuralgia 显示文摘 | SAMPATHKUMAR P DRAGE LA MARTIN DP | 2009 | Mayo Clin Proc2009，84，3： | 1 |
| 6 | Herpes zoster ( shingles ) and postherpetic neuralgia 显示文摘 | Sampathkumar P Drage LA Martin DP | 2009 | Mayo Clin Proc2009，84，： | 1 |
| 7 | Herpes zoster (shingles) and postherpetic neuralgia 显示文摘 | Sampathkumar P Drage LA Martin DP | 2009 | Mayo Clin Proc2009，84，： | 1 |
| 8 | Herpes zoster (shingles) and postherpetic neuralgia 显示文摘 | Sampathkumar P Drage LA Martin DP | 2009 | Mayo Clin Proc2009，84，3： | 1 |
| 9 | Evaluation of heavy metal contamination in surface soil around industrial area,Tamil Nadu,India显示文摘 | DHEEBA B SAMPATHKUMAR P | 2012 | International Journal of ChemTech Research2012，4，3： | 1 |
| 10 | Effect of copper on growth and enzymeactivities of marine diatom, Odontella mobiliensis显示文摘 | Manimaran K Karthikeyan P Ashokkumar S’ Prabu V A Sampathkumar P | 2012 | Bulletin of Environmental Contamination and Toxicology2012，88，1： | 1 |
| 11 | Synthesis and characterization of bioconjugates of S-layer proteins显示文摘 | Sampathkumar P Gilchrist ML | | 0，，4： | 1 |
| 12 | Herpes zoster (shin- gles) and postherpetic neuralgia 显示文摘 | Sampathkumar P Drage LA Martin DP | 2009 | Mayo Clin Proc2009，84，3： | 1 |
| 13 | Herpes zoster(shingles)and postherpetic neuralgia显示文摘 | Sampathkumar P Drage LA Martin DP | 2009 | M ayo Clin Proe2009，84，： | 1 |
| 14 | Complications of Central Venous Catheterization显示文摘 | Bauer PR Daniels CE Sampathkumar P | 2016 | N Engl J Med2016，374，15： | 1 |
| 15 | Middle East respiratory syndrome: what clinicians need to know 显示文摘 | Sampathkumar P | 2014 | Mayo Clin Proc2014，89，8： | 1 |
| 16 | Synthesis and charac-terization of bioconjugates of S-layer proteins显示文摘 | SAMPATHKUMAR P LANE GILCHRIST M | 2004 | Bioconjugate Chem2004，15，4： | 1 |
| 17 | Sternal wound infections显示文摘 | Mauermann WJ Sampathkumar P Thompson RL | 2008 | Best Pract Res Clin Anaesthesiol2008，22，3： | 1 |
| 18 | Herpes zoster(shin- gles) and postherpetic neuralgia显示文摘 | Sampathkumar P Drage LA Martin DP | 2009 | Mayo Clin Proc2009，84，3： | 1 |
| 19 | Herpes zoster (shingles) and postherpetie neuralgia显示文摘 | Sampathkumar P Drage LA Martin DP | 2009 | Mayo Clin Proe2009，84，3： | 1 |
| 20 | What clinicians should know about the 2014 Ebola outbreak 显示文摘 | Tosh PK Sampathkumar P | 2014 | Mayo Clin Proc2014，89，12： | 1 |
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