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| 1 | Neutrophil gelatinase-associated lipocalin does not predict acute kidney injury in heart failure显示文摘BACKGROUND Acute cardiorenal syndrome type 1(CRS-1)is defined by a rapid cardiac dysfunction leading to acute kidney injury(AKI).Neutrophil gelatinaseassociated lipocalin(NGAL)is expressed on the surface of human neutrophils and epithelial cells,such as renal tubule cells,and its serum(sNGAL)and urinary have been used to predict AKI in different clinical settings.AIM To characterize CRS-1 in a cohort of patients with acute heart diseases,evaluating the potentiality of sNGAL as an early marker of CRS-1.METHODS We performed a retrospective cohort,multi-centre study.From January 2010 to December 2011,we recruited 202 adult patients admitted to the coronary intensive care unit(CICU)with a diagnosis of acute heart failure or acute coronary syndrome.We monitored the renal function to evaluate CRS-1 development and measured sNGAL levels within 24 h and after 72 h of CICU admission.RESULTS Overall,enrolled patients were hemodynamically stable with a mean arterial pressure of 92(82-107)mmHg,55/202(27.2%)of the patients developed CRS-1,but none of them required dialysis.Neither the NGAL delta value(AUC 0.40,95%CI:0.25-0.55)nor the NGAL peak(AUC 0.45,95%CI:0.36-0.54)or NGAL cutoff(≥140 ng/mL)values were statistically significant between the two groups(CRS-1 vs no-CRS1 patients).The area under the ROC curve for the prediction of CRS-1 was 0.40(95%CI:0.25-0.55)for the delta NGAL value and 0.45(95%CI:0.36-0.54)for the NGAL peak value.Finally,in multivariate analysis,the risk of developing CRS-1 was correlated with age>60 years,urea nitrogen at admission and 24 h-urine output(AUC 0.83,SE=60.5%SP=93%),while sNGAL was not significantly correlated.CONCLUSION In our population,sNGAL does not predict CRS-1,probably as a consequence of the mild renal injury and the low severity of heart disease.So,these data might suggest that patient selection should be taken into account when considering the utility of NGAL measurement as a biomarker of kidney damage. | Fiorenza Ferrari Elisa Scalzotto Pasquale Esposito Sara Samoni Flavio Mistrorigo Lilia Maria Rizo Topete Massimo De Cal Grazia Maria Virzì Valentina Corradi Rossella Torregrossa Roberto Valle Stefania Bianzina Nadia Aspromonte Matteo Floris Alessandro Fontanelli Alessandra Brendolan Claudio Ronco | 2020 | World Journal of Clinical Cases2020，8，9： | 3 |
| 2 | Effect of aminoglycoside and beta-lactam combination therapy versus beta-lactam monotherapy on the emergence of antimicrobial resistance: a recta-analysis of randomized, controlled trials显示文摘 | Bliziotis IA Samonis G Vardakas KZ | 2005 | Clin Infect Dis2005，41，2： | 1 |
| 3 | In vitro antimicrobial susceptibility to isepamicin of 6,296 Enterobacteriaceae clinical isolates collected at a tertiary care university hospital in Greece显示文摘 | Maraki S Samonis G Karageorgopoulos DE | 2012 | Antimicrob Agents Chemother2012，56，4： | 1 |
| 4 | Clinical presentation of zy- gomycosis显示文摘 | MANTADAKIS E SAMONIS G | 2009 | Clin Microbiol Infect2009，155，： | 1 |
| 5 | Stenotrophomonas maltophilia infections in a general hospital: patient characteristics, antimicrobial susceptibility, and treatment outcome显示文摘 | Samonis G Karageorgopoulos D E Maraki S | 2012 | PLoS One2012，7，37： | 1 |
| 6 | Candidemia in im-munocompromised and immunocompetent critically ill patients:aprospective comparative study显示文摘 | Dimopoulos G Karabinis A Samonis G | 2007 | Eur J Clin Microbiol InfectDis2007，26，： | 1 |
| 7 | Treatment of non-small-cell lung cancer with prolonged oral etoposide显示文摘 | KAKOLYRIS S SAMONIS G KOUKOURAKIS M | 1998 | Am J Clin Oncol1998，21，1： | 1 |
| 8 | Comparison of docetaxel/cisplatin to docetaxel/gemcitabine as first-line treatment of advanced non-small cell lung cancer:early results of a randomized trial显示文摘 | Georgoulias V Samonis G Papadakis E | | 0，，4： | 1 |
| 9 | Transient fungemia due to Rhodotorula rubra in a cancer patient: case re- port and review of the literature 显示文摘 | Samonis G Anatoliotaki M Apostolakou H | 2001 | J Infect2001，29，3： | 1 |
| 10 | Bullous erysipelas:clinical presentation staphylococcal involvement and methicillin resistance显示文摘 | Krasagakis K Samonis G Maniatakis P | | 0，，01： | 1 |
| 11 | Clinical significance of the pharmacokinetic and pharmacodynamic characteristics of fosfomycin for the treatment of patients with systemic infections显示文摘 | Roussos N Karageorgopoulos DE Samonis G | 2009 | Int J Antimicrob Agents2009，34，6： | 1 |
| 12 | Candidemia in immunocompromised and immunocompetent critically ill patients: a prospective comparative study显示文摘 | Dimopoulos G Karabinis A Samonis G | 2007 | Eur J Clin Mierobiol Infect Dis2007，26，6： | 1 |
| 13 | Mortality and morbidity of HIV infected patient receiving HAART:a cohort study显示文摘 | Panos G Samonis G Alexiou V G Kavarnou G A Charatsis G and FaLagas M E | 2008 | Curr H1V Res2008，6，2： | 1 |
| 14 | Incidence,clinical,microbiological features and outcome of bloodstream infections in patients undergoing hemodialysis显示文摘 | Fysaraki M Samonis G Valachis A | 2013 | Int J Med Sci2013，10，12： | 1 |
| 15 | Anti- fungal prophylaxis with azoles in high-risk, surgical in- tensive care unit patients: A metaanalysis of random- ized, placebo-controlled trials显示文摘 | Vardakas K Samonis G Michalopoulos A | 2006 | Critical Care Med2006，34，4： | 1 |
| 16 | Pulmonary mucormycosis显示文摘 | Hamilos G Samonis G Kontoyiannis DP | 2011 | Semin Respir Crit Care Med2011，32，6： | 1 |
| 17 | Sustaining innovation:theory and policies for New Europe显示文摘 | Samonis Valdas | 2004 | Ekonomika2004，，： | 1 |
| 18 | Candida albicans versus non-albicans bloodstream infection in patients in a tertiary hospital : An analysis of microbiological data显示文摘 | Samonis G Kofteridis D P Saloustros E | 2008 | Scand J Infect Dis2008，40，5： | 1 |
| 19 | Successful treatment of refractory disseminated Myco-bacterium avium complex infection with the addition of linezol id and mefloquine显示文摘 | Nannini EC Keating M Binstock P Samonis G Kontoyiannis DP | 2002 | J Infect2002，44，3： | 1 |
| 20 | Candidemia in im-munocompromised and immunocompetent critically ill patients:aprospective comparative study显示文摘 | Dimopoulos G Karabinis A Samonis G | 2007 | Eur J Clin Microbiol InfectDis2007，26，6： | 1 |
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