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| 1 | Circulating tumor and cancer stem cells in hepatitis C virusassociated liver disease显示文摘AIM:To assess the role of circulating tumor cells(CTCs)and cancer stem cells(CSCs)in hepatitis C virus(HCV)-associated liver disease.METHODS:Blood and/or tissue samples were obtained from HCV(genotype 4)-associated hepatocellularcarcinoma patients(HCC;n=120),chronic hepatitis C patients(CH;n=30)and 33 normal control subjects(n=33).Serum levels of alpha-fetoprotein(AFP),alkaline phosphatase,and alanine and aspartate aminotransferases were measured.Cytokeratin 19(CK19)monoclonal antibody was used to enumerate CTCs,and CD133 and CD90 were used to enumerate CSCs by flow cytometry.The expression levels of the CSCs markers(CD133 and CD90)as well as telomerase,melanoma antigen encoding gene 1(MAGE1)and MAGE3 were assessed by RTPCR and quantitative real-time polymerase chain reactions.The number of CTCs and/or the expression levels of CK19,CD133,telomerase,MAGE1 and MAGE3 were correlated to the standard clinicopathologic prognostic factors and disease progression.RESULTS:Levels of AFP,alkaline phosphatase and aspartate aminotransferase were significantly different among the HCC,CH and control groups(P<0.001),whereas alanine aminotransferase differed significantly between patient(HCC and CH)and control groups(P<0.001).At the specified cutoff values determine by flow cytometry,CK19(49.8),CD90(400)and CD133(73)were significantly higher in the blood of HCC patients compared to those in the CH and control groups(P<0.001).On the other hand,CD133 at a 69.5 cutoff was significantly higher in the CH compared to the control group(P≤0.001).Telomerase,MAGE1 and MAGE3RNA were expressed in 55.71%,60.00%and 62.86%of the HCC patients,respectively,but were not detected in patients in the CH or control groups,which were statistically significant(Ps<0.001).The expression levels of telomerase,CD90,MAGE3,CD133 and CK19 were all significantly associated with high tumor grade and advanced stage in HCC patients(all P s<0.05).CONCLUSION:CTC counts and AFP,CK19,telomerase,and MAGE1/MAGE3 expression predict disease progression in patients with HCV,whereas telomerase,MAGE3,CD90,CD133 and CK19 are prognostic mark- | Abeer A Bahnassy Abdel-Rahman N Zekri Ahmed El-Bastawisy Amal Fawzy Marwa Shetta Nehal Hussein Dalia Omran Abdallah A S Ahmed Samir S El-Labbody | 2014 | World Journal of Gastroenterology2014，20，48： | 9 |
| 2 | Analysis of brake squeal noise using the finite lement: A parametric method 显示文摘 | Mario Triches Junior Samir N Y Gerges Roberto Jordan | 2008 | Applied Acoustics2008，69，2： | 1 |
| 3 | Amalgamation of procalcitonin, C-reactive protein, and sequential organ failure scoring system in predicting sepsis survival显示文摘 | Hegazy MA Omar AS Samir N | 2014 | Anesth Essays Res2014，8，3： | 1 |
| 4 | Estimation of tissue and serum lipocalin-2 in psoriasis vulgaris and its relation to metabolic syndrome显示文摘 | E1-Hadidi H Samir N Shaker OG | 2014 | Arch Dermatol Res2014，306，3： | 1 |
| 5 | Honey and amixture of honey,beeswax,and olive oil - propolis extract intreatment of chemotherapy - induced oral mucositis: a ran-domized controlled pilot study 显示文摘 | Abdulrhman M Samir El Barbary N | 2012 | Pediatr Hematol Oncol2012，29，3： | 1 |
| 6 | Effect of moisture and temperature on the mechanical properties of concrete显示文摘 | Samir N S Gergis W W Brian D | 2011 | Construction and Building Materials2011，25，2： | 1 |
| 7 | Rotary heat exchanger performance with axial heat dispersion 显示文摘 | SANKAR N SAMIR V DHINGRA S C | 1998 | International Journal of Heat and Mass Transfer1998，，41： | 1 |
| 8 | Konar development of an analytical method for the determination of glyphosate residues in soil by nitrogen-selective gas chromatography 显示文摘 | Samir K | 1989 | J Agric Food Chem1989，37，： | 1 |
| 9 | Honey and amixture of honey,beeswax,and olive oil - propolis extract intreatment of chemotherapy - induced oral mucositis: a ran-domized controlled pilot study 显示文摘 | Abdulrhman M Samir El Barbary N | 2012 | Pediatr Hematol Oncol2012，29，3： | 1 |
| 10 | The dynamics of lead-screw drives:low-order modeling and experiments显示文摘 | Kripa K V Samir A N | 2004 | Transactions ofASME Journal of Dynamic Systems Measurement andcontrol2004，126，2： | 1 |
| 11 | High capacity lossless data embedding technique for palette images based on histogram analysis 显示文摘 | Noura A Saleh Hoda N Boghdady Samir I Shaheen | 2010 | Digital Signal Proces- sing2010，20，6： | 1 |
| 12 | Analysis of Brake Squeal Noise Using the Finite Element Method 显示文摘 | Mario T J Samir N Y G Roberto J | 2008 | Applied Acoustics2008，，69： | 1 |
| 13 | Budgeted maximum coverage problem显示文摘 | SAMIR K ANNA M JOSEPF N | 1999 | Information Processing Letters1999，70，1： | 1 |
| 14 | Structured H2 optimization of vehicle suspensions based on multi-wheel models显示文摘 | Zuo L Samir A N | 2003 | Vehicle System Dynamics2003，40，5： | 1 |
| 15 | Can short-term fasting protect against doxorubicin-induced cardiotoxicity?显示文摘Doxorubicin(Dox) is one of the most effective chemotherapeutic agents used in the treatment of several types of cancer. However the use is limited by cardiotoxicity. Despite extensive investigation into the mechanisms of toxicity and preventative strategies, Dox-induced cardiotoxicity still remains a major cause of morbidity and mortality in cancer survivors. Thus, continued research into preventative strategies is vital. Short-term fasting has proven to be cardioprotective against a variety of insults. Despite the potential, only a few studies have been conducted investigating its ability to prevent Dox-induced cardiotoxicity. However, all show proof-of-principle that short-term fasting is cardioprotective against Dox. Fasting affects a plethora of cellular processes making it difficult to discern the mechanism(s) translating fasting to cardioprotection, but may involve suppression of insulin and insulin-like growth factor-1 signaling with stimulated autophagy. It is likely that additional mechanisms also contribute. Importantly, the literature suggests that fasting may enhance the antitumor activity of Dox. Thus, fasting is a regimen that warrants further investigation as a potential strategy to prevent Dox-induced cardiotoxicity. Future research should aim to determine the optimal regimen of fasting, confirmation that this regimen does not interfere with the antitumor properties of Dox, as well as the underlying mechanisms exerting the cardioprotective effects. | Amie J Dirks-Naylor Samir A Kouzi Sendra Yang Ngan TK Tran Joseph D Bero Raean Mabolo Diep T Phan Stephanie D Whitt Heather N Taylor | 2014 | World Journal of Biological Chemistry2014，5，3： | 1 |
| 16 | An interior-point Benders based branchand-cut algorithm for mixed integer programs显示文摘 | JOE N S SAMIR E | 2013 | Annals Operations Research2013，210，1： | 1 |
| 17 | Nurses' attitudes and reactions to workplace violence in obstetrics and gynaecology departments in Cairohospitals显示文摘 | Samir N Mohamed R Moustafa E | 2012 | East Mediterr Health J2012，18，3： | 1 |
| 18 | 5-year outcomes of transcatheter aortic valve replacement or surgical aortic valve replacement for high surgical risk patients with aortic stenosis (PARTNER 1): a randomised controlled trial显示文摘 | Michael J Mack Martin B Leon Craig R Smith D Craig Miller Jeffrey W Moses E Murat Tuzcu John G Webb Pamela S Douglas William N Anderson Eugene H Blackstone Susheel K Kodali Raj R Makkar Gregory P Fontana Samir Kapadia Joseph Bavaria Rebecca T Hahn Vinod H | 2015 | The Lancet . 2015 (9986)2015，，： | 1 |
| 19 | Liquid hydrocarbons from catalytic pyrolysis of sewage sludge lipid and canola oil:evaluation of fuel properties显示文摘 | BAHADUR N P DAVID G B SAMIR K K | 1995 | Energy Fuels1995，9，2： | 1 |
| 20 | Effect of moisture and temperature on the mechanical properties of concrete显示文摘 | Samir N S Gergis W W Brian D | 2011 | Construction and Building Materials2011，25，2： | 1 |
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