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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Sequential organ failure assessment score is superior to other prognostic indices in acute pancreatitis显示文摘BACKGROUND Acute pancreatitis(AP)is a common surgical condition,with severe AP(SAP)potentially lethal.Many prognostic indices,including;acute physiology and chronic health evaluation II score(APACHE II),bedside index of severity in acute pancreatitis(BISAP),Glasgow score,harmless acute pancreatitis score(HAPS),Ranson’s score,and sequential organ failure assessment(SOFA)evaluate AP severity and predict mortality.AIM To evaluate these indices'utility in predicting severity,intensive care unit(ICU)admission,and mortality.METHODS A retrospective analysis of 653 patients with AP from July 2009 to September 2016 was performed.The demographic,clinical profile,and patient outcomes were collected.SAP was defined as per the revised Atlanta classification.Values for APACHE II score,BISAP,HAPS,and SOFA within 24 h of admission were retrospectively obtained based on laboratory results and patient evaluation recorded on a secure hospital-based online electronic platform.Data with<10%missing data was imputed via mean substitution.Other patient information such as demographics,disease etiology,and patient outcomes were also derived from electronic medical records.RESULTS The mean age was 58.7±17.5 years,with 58.7%males.Gallstones(n=404,61.9%),alcohol(n=38,5.8%),and hypertriglyceridemia(n=19,2.9%)were more common aetiologies.81(12.4%)patients developed SAP,20(3.1%)required ICU admission,and 12(1.8%)deaths were attributed to SAP.Ranson’s score and APACHE-II demonstrated the highest sensitivity in predicting SAP(92.6%,80.2%respectively),ICU admission(100%),and mortality(100%).While SOFA and BISAP demonstrated lowest sensitivity in predicting SAP(13.6%,24.7%respectively),ICU admission(40.0%,25.0%respectively)and mortality(50.0%,25.5%respectively).However,SOFA demonstrated the highest specificity in predicting SAP(99.7%),ICU admission(99.2%),and mortality(98.9%).SOFA demonstrated the highest positive predictive value,positive likelihood ratio,diagnostic odds ratio,and overall accuracy in predicting SAP,ICU admission,and mortality.SOFA and Ranson’s score demonstrated the highest area under receiver-operator curves at 48 h in predicting SAP(0.966,0.857 respectively),ICU admission(0.943,0.946 respectively),and mortality(0.968,0.917 respectively).CONCLUSION The SOFA and 48-h Ranson’s scores accurately predict severity,ICU admission,and mortality in AP,with more favorable statistics for the SOFA score. | Thomas Zheng Jie Teng Jun Kiat Thaddaeus Tan Samantha Baey Sivaraj K Gunasekaran Sameer P Junnarkar Jee Keem Low Cheong Wei Terence Huey Vishal G Shelat | 2021 | World Journal of Critical Care Medicine2021，10，6： | 9 |
| 3 | Microstructure,mechanical response and fractography of AZ91E/Al_(2)O_(3)_(p) nano composite fabricated by semi solid stir casting method显示文摘The present study confers to the fabrication and its characterization of magnesium alloy(AZ91E)based nano composites with nano Al_(2)O_(3) particulate reinforcements.A novel Semi Solid stir casting technique was adopted for the fabrication of the composite.An average particle size of 50 nm was used as reinforcement to disperse in matrix.The effects of change in weight fraction of reinforcements on the distribution of particles,particle–matrix interfacial reactions,physical as well as mechanical properties were reported.The SEM and EDS analysis has shown the uniform distribution of particles in the composite along with the presence of elements.The mechanical properties of reinforced and unreinforced composite were evaluated and presented.Fractography of tensile specimens was also discussed. | Sameer Kumar D Suman K.N.S Tara Sasanka C Ravindra K Palash Poddar | 2017 | Journal of Magnesium and Alloys2017，5，1： | 4 |
| 4 | Prevalence of unsuspected thyroid nodules in adults on contrast enhanced 16-and 64-MDCT of the chest显示文摘AIM: To determine the prevalence of unsuspected thyroid nodules on contrast enhanced 16and 64-modified discrete cosine transform (MDCT) of the chest, in a population of adult outpatients imaged for indications other than thyroid disease. METHODS: This retrospective study involved review of intravascular contrast-enhanced MDCT scans of the chest from 3077 consecutive adult outpatients, to identify unsuspected thyroid nodules. Exclusion criteria included history of thyroid cancer, known thyroid nodules or thyroid disease and risk factors for thyroid cancer, as evidenced by their medical records. One of 9 radiologists recorded number of nodules, location and bidirectional measurement of largest nodule, as well as amount of thyroid visualized on the chest computed tomography (CT). Presence of nodule was correlated with age, gender, race and percentage of thyroid imaged. RESULTS: A total of 2510 (2510/3077 or 81.6%) study subjects were included in the data analysis; among them,one or more nodules were identified in 629 subjects (629/2510 or 25.1%), with 242 (242/629 or 38.5%) having multiple nodules. Patients with nodule(s) were significantly older than those without (64 ± 13 years vs 58 ± 14 years, P < 0.0001), and female gender was associated with presence of nodule(s) (373/1222 or 30.5% vs 256/1288 or 19.9%, P < 0.0001). Women were also more likely having multiple nodules (167/373 or 44.8%) compared to men (75/256 or 29.3%, P < 0.0001). The majority of nodules (427/629 or 67.9%) were less than 1 cm. CONCLUSION: This retrospective review revealed a prevalence of 25.1% for unsuspected thyroid nodules on contrast-enhanced chest CT. | Sameer Ahmed Pamela T Johnson Karen M Horton Atif Zaheer Saline Tsai Elliot K Fishman | 2012 | World Journal of Radiology2012，4，7： | 4 |
| 5 | Rainfall-induced land- slide susceptibility zonation of Puerto Rico显示文摘 | Lepore C Sameer A K Peter S | 2012 | Environ- mental Earth Sciences2012，，66： | 1 |
| 6 | Left Ventricular Hypertrophy,Subclinical Atherosclerosis,and Inflammation显示文摘 | Sameer K Mehta J Eduardo Rame | 2007 | Hypertension2007，49，13： | 1 |
| 7 | Strategic alliance in a closed-loop supply chain,a case of manufacturer and eco-non-profit organization显示文摘 | Sameer K Malegean P | | 0，，26： | 1 |
| 8 | A fast and elitist mulyi-objective genetic algorithm:NSGA-Ⅱ显示文摘 | Deb K Amrit P Sameer A | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 9 | Utilizing DMAIC six sigma and evidence-based medicine to streamline显示文摘 | Sameer K Kory M | 2010 | Quality Management in Health Care2010，19，2： | 1 |
| 10 | A learning-based similarity fusion and filtering approach for bio- medical image retrieval using SVM classification and relevance feedback 显示文摘 | Rahman Md Mahmudur Antani Sameer K Thoma George R | 2011 | IEEE Transactions on Information Technology in Biomedicine2011，15，4： | 1 |
| 11 | Thermal performance of closed two-phase thermosyphon using nanofluids显示文摘 | Sameer K Yogesh M J Balkrishna M | 2008 | International Journal of Thermal Sciences2008，47，6： | 1 |
| 12 | A fast and elitist multi- objective genetic algorithm: NSGA-Ⅱ显示文摘 | Deb K Amrit P Sameer A | 2002 | IEEE Transac- tions on Evolutionary Computation2002，6，2： | 1 |
| 13 | An efficient maximum likeli- hood carrier frequency offset estimator for OFDM using null subcarri- ers and cycle prefix 显示文摘 | SAMEER S M RAJA K UMAR R V | 2011 | Wireless Personal Communications2011，58，2： | 1 |
| 14 | Molecular and epidemiologieal features of gastroenteritis outbreaks involving genogroup I norovir- us in Victoria, Australia, 2002-2010显示文摘 | Bruggink L D Oluwatoyin O Sameer R Witlox K J Marshall J A | 2012 | J Med Virol2012，84，： | 1 |
| 15 | A Fast and Elitist Multiobjective Genetic Algorithm: NSGA-II 显示文摘 | K Deb Amrit Pratap Sameer Agarwal T Meyarivan | 2002 | IEEE Transactions on Evolutionary Computation (S1089-778X)2002，6，2： | 1 |
| 16 | Late endocarditis of Amplatzer atrial septal occluder device in a child显示文摘Bacterial endocarditis following atrial septal defect closure using Amplatzer device in a child is extremely rare. We report a 10-year-old girl who developed late bacterial endocarditis, 6 years after placement of an Amplatzer atrial septal occluder device. Successful explantation of the device and repair of the resultant septal defect was carried out using a homograft patch. The rare occurrence of this entity prompted us to highlight the importance of a closed long-term follow up, review the management and explore preventive strategies for similar patients who have multiple co-morbidities and a cardiac device. A high index of suspicion is warranted particularly in pediatric patients. | Neerod K Jha Laszlo Kiraly John SK Murala Csaba Tamas Haitham Talo Hazem El Badaoui Magdi Tofeig Malaika Mendonca Sameer Sajwani Mary A Thomas Sura Ahmed Al Doory Mohammad D Khan | 2015 | World Journal of Cardiology2015，7，10： | 1 |
| 17 | Enhancing privacy management support ininstant messaging 显示文摘 | Sameer Patil A K | 2010 | Interacting with Computers2010，22，3： | 1 |
| 18 | 显示文摘 | Suresh C K Swanand D P Sameer D | 2005 | J Phys Chem B2005，109，： | 1 |
| 19 | Retroperitoneal schwannoma mimicking an adrenal lesion显示文摘 | Sameer K Sharma1 F C Koleskil | 2002 | World J Urol2002，20，4： | 1 |
| 20 | A Survey on the Use of Pattern Recognition Methods for Abstraction, Indexing and Retrieval of Images and Video 显示文摘 | Sameer A Rangachar K Ramesh J | 2002 | Pattern Recognition2002，，35： | 1 |
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