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| 1 | Pancreatic regenerating protein (regⅠ) and regⅠreceptor mRNA are upregulated in rat pancreas after induction of acute pancreatitis显示文摘AIM: Pancreatic regenerating protein (regⅠ) stimulates pancreatic regeneration after pancreatectomy and is mitogenic to ductal andβ-cells. This suggests that regⅠand its receptor may play a role in recovery after pancreatic injury. We hypothesized that regⅠand its receptor are induced in acute pancreatitis. METHODS: Acute pancreatitis was induced in male Wistar rats by retrograde injection of 3% sodium taurocholate into the pancreatic duct. Pancreata and serum were collected 12, 24, and 36 hours after injection and from normal controls (4 rats/group). RegⅠreceptor mRNA, serum regⅠprotein, and tissue regⅠprotein levels were determined by Northern analysis, enzyme-linked immunosorbent assay (ELISA), and Western analysis, respectively. Immunohistochemistry was used to localize changes in regⅠand its receptor. RESULTS: Serum amylase levels and histology confirmed necrotizing pancreatitis in taurocholate treated rats. There was no statistically significant change in serum regⅠconcentrations from controls. However, Western blot demonstrated increased tissue levels of regⅠat 24 and 36 h. This increase was localized primarily to the acinar cells and the ductal cells by immunohistochemistry. Northern blot demonstrated a significant increase in regⅠreceptor mRNA expression with pancreatitis. Immunohistochemistry localized this increase to the ductal cells, islets, and acinar cells. CONCLUSION: Acute pancreatitis results in increased tissue regⅠprotein levels localized to the acinar and ductal cells, and a parallel threefold induction of regⅠreceptor in the ductal cells, islets, and acinar cells. These changes suggest that induction of reg I and its receptor may be important for recovery from acute pancreatitis. | Martin H Bluth Sameer A Patel Brian K Dieckgraefe Hiroshi Okamoto Michael E Zenilman | 2006 | World Journal of Gastroenterology2006，12，28： | 19 |
| 2 | Effect of precut sphincterotomy on post-endoscopic retrograde cholangiopancreatography pancreatitis:A systematic review and meta-analysis显示文摘AIM:To conduct a systemic review and meta-analysis to investigate the role of early precut technique.Multiple randomized controlled trails(RCTs)have reported conflicting results of the early precut sphincterotomy.METHODS:MEDLINE/PubMed,EMBASE,Cochrane Central Register of Controlled Trials and Database of Systematic Reviews,and recent abstracts from major conference proceedings were searched(June 2013).Randomized and non-randomized studies comparing early precut technique with prolonged standard methods were included.Pooled estimates of post-endoscopic retrograde cholangiopancreatography(ERCP)pancreatitis(PEP),cannulation and adverse events were analyzed by using odds ratio(OR).Random and fixed effects models were used as appropriate.Publication bias was assessed by funnel plots.Heterogeneity among studies was assessed by calculating I2 measure of inconsistency.RESULTS:Seven randomized and seven non-randomized trials met inclusion criteria.Meta-analysis of RCTs showed a decrease trend for PEP with early precut sphincterotomy but was not statistically significant(OR=0.58;95%CI:0.32-1.05;P=0.07).No heterogeneity was noted among the studies with I2 of 0%.CONCLUSION:Early precut technique for common bile duct cannulation decreases the trend of post-ERCP pancreatitis. | Abhishek Choudhary Jessica Winn Sameer Siddique Murtaza Arif Zainab Arif Ghassan M Hammoud Srinivas R Puli Jamal A Ibdah Matthew L Bechtold | 2014 | World Journal of Gastroenterology2014，20，14： | 13 |
| 3 | Imaging of liver cancer显示文摘Improvements in imaging technology allow exploitation of the dual blood supply of the liver to aid in the identif ication and characterisation of both malignant and benign liver lesions. Imaging techniques available include contrast enhanced ultrasound, computed tomography and magnetic resonance imaging. This review discusses the application of several imaging techniques in the diagnosis and staging of both hepatocellular carcinoma and cholangiocarcinoma and outlines certain characteristics of benign liver lesions. The advantages of each imaging technique are highlighted, while underscoring the potential pitfalls and limitations of each imaging modality. | Ben Ariff Claire R Lloyd Sameer Khan Mohamed Shariff Andrew V Thillainayagam Devinder S Bansi Shahid A Khan Simon D Taylor-Robinson Adrian KP Lim | 2009 | World Journal of Gastroenterology2009，15，11： | 4 |
| 4 | Expression of a cysteine proteinase inhibitor (oryzacystatin-I) in trangenic tobacco plant显示文摘 | | 1993 | Plant Molecular Biology1993，21，： | 1 |
| 5 | Jacobian Analysis of Limited-DOF Parallel Manipulators显示文摘 | Sameer A Joshi Tsai Lung-Wen | 2002 | Journal of Me-chanical Design2002，124，2： | 1 |
| 6 | Jacobian analysis of limited DOF parallel manipulator显示文摘 | Tsai-L W Sameer A J | 2002 | Journal of Mechanical Design2002，124，2： | 1 |
| 7 | A Fast and Elitist Multi--objective Genetic Algorithm: NSGA -Ⅱ显示文摘 | Kalyanmoy D Amrit P Sameer A | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 8 | Exploring fungal biodiversity for the production of water-soluble pigments as potential natural food colorants显示文摘 | SAMEER A S MAPARI KRISTIAN F NIELSEN THOMAS O LARSEN | 2005 | Current Opinion in Biotechnology2005，16，： | 1 |
| 9 | A fast and elitist multiobjective genetic algorithm:NSGA-II显示文摘 | Kalyanmoy D Amrit P Sameer A | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 10 | An improved SVD-based watermarking scheme for protecting rightful ownership显示文摘 | Mohammad A A Alhaj A Sameer S | 2008 | Signal Processing2008，88，9： | 1 |
| 11 | A fast and elitist multiobjective genetic algorithm: NSGA-II显示文摘 | Kalyanmoy D Amrit P Sameer A | 2002 | IEEE Transactions on Evolutionary Compuation2002，6，2： | 1 |
| 12 | Variation of the fracture toughness of concrete with temperature显示文摘 | Hisham Abdel-Fattah Sameer A Hamoush | 1997 | 11(2):1051997，11，2： | 1 |
| 13 | Rainfall-induced land- slide susceptibility zonation of Puerto Rico显示文摘 | Lepore C Sameer A K Peter S | 2012 | Environ- mental Earth Sciences2012，，66： | 1 |
| 14 | A fast andelitist multiobjective genetic algorithm: NSGA - II 显示文摘 | KALYANM0YD AMRIT P SAMEER A | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 15 | An improved SVD- based watermarking scheme for protecting rightful ownership显示文摘 | MOHAMMAD A A SAMEER SILIAL:I'AId:A A | 2008 | Si9- hal Processing2008，88，9： | 1 |
| 16 | A fast and elitist muhiobjective genetic algorithm : NSGA- lI显示文摘 | Kalyanmoy D Amrit P Sameer A | 2002 | IEEE Trans- actions On Evolutionary Computation2002，6，2： | 1 |
| 17 | A fast and elitist mulyi-objective genetic algorithm:NSGA-Ⅱ显示文摘 | Deb K Amrit P Sameer A | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 18 | A fast elitist multi-ob- jective genetic algorithm : NSGA-II 显示文摘 | Kalyanmoy D Amrit P Sameer A | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
| 19 | Reduced lignin content and altered lignin composition in transgenic tobacco down-regulated in expression of L-phenylalanine ammonia-lyase or cinnamate 4-hydroxylase显示文摘 | Vincent J H S Weiting N Jack W B Hans G J Sameer A M Paul A H Chris L and Richard A D | | 0，，： | 1 |
| 20 | A fast and elitist muhlobjective genetic algorithm : NSGA-II 显示文摘 | Kalyanmoy D Amrit P Sameer A | 2002 | IEEE Transactions on Evolutionary Computation2002，6，2： | 1 |
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