|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Current trends in staging rectal cancer显示文摘Management of rectal cancer has evolved over the years. In this condition preoperative investigations assist in deciding the optimal treatment. The relation of the tumor edge to the circumferential margin (CRM) is an important factor in deciding the need for neoadjuvant treatment and determines the prognosis. Those with threatened or involved margins are offered long course chemoradiation to enable R0 surgical resection. Endoanal ultrasound (EUS) is useful for tumor (T) staging; hence EUS is a useful imaging modality for early rectal cancer. Magnetic resonance imaging (MRI) is useful for assessing the mesorectum and the mesorectal fascia which has useful prognostic significance and for early identification of local recurrence. Computerized tomography (CT) of the chest, abdomen and pelvis is used to rule out distant metastasis. Identification of the malignant nodes using EUS, CT and MRI is based on the size, morphology and internal characteristics but has drawbacks. Most of the common imaging techniques are suboptimal for imaging following chemoradiation as they struggle to differentiate fibrotic changes and tumor. In this situation, EUS and MRI may provide complementary information to decide further treatment. Functional imaging using positron emission tomography (PET) is useful, particularly PET/CT fusion scans to identify areas of the functionally hot spots. In the current state, imaging has enabled the multidisciplinary team of surgeons, oncologists, radiologists and pathologists to decide on the patient centered management of rectal cancer. In future, functional imaging may play an active role in identifying patients with lymph node metastasis and those with residual and recurrent disease following neoadjuvant chemoradiotherapy. | Abdus Samee Chelliah Ramachandran Selvasekar | 2011 | World Journal of Gastroenterology2011，17，7： | 26 |
| 2 | 刀额新对虾主要过敏原蛋白的肽指纹图谱鉴定与分析显示文摘以我国常见的刀额新对虾为研究对象,旨在获得其主要过敏原的氨基酸序列等基础数据,增加对虾类过敏原的认识和理解。分离和纯化了分子量为36 kD的虾主要过敏原蛋白,利用激光辅助解析/飞行时间质谱对其进行肽质量指纹图谱鉴定,并对鉴定的结果采用Mascot搜索引擎在NCBInr数据库上进行搜索。结果表明刀额新对虾主要过敏原蛋白与斑节对虾原肌球蛋白匹配分值最高为268,吻合肽段27条,序列覆盖率为65%;与其它无脊椎动物如腐食酪螨、衣鱼等的原肌球蛋白的序列覆盖率也很高,分别达到了51%和53%。这一结果不仅表明了刀额新对虾与其它甲壳类海产品过敏原存在着高度同源性,而且为其与甲壳类及其它无脊椎动物主要过敏原之间存在严重交叉反应的现象提供了理论依据。 | 林洪 郑礼娜 李振兴 Samee Haider | 2009 | 中国海洋大学学报(自然科学版)2009，39，5： | 6 |
| 3 | 菲律宾蛤仔过敏原可视化抗体微阵列玻片的检测方法显示文摘采用辣根过氧化物酶(HRP)与3,3′,5,5′—四甲基联苯胺(TMB)—H2O2作为信号示踪系统,建立了一种可视化抗体微阵列检测菲律宾蛤仔过敏原的方法。对孵育时间、抗体浓度等免疫条件进行了优化。采用改良双抗体夹心法,将菲律宾蛤仔过敏原的兔多克隆抗体固定于琼脂糖三维芯片上,依次加入待检样品、菲律宾蛤仔鼠多克隆抗体和HRP-羊抗鼠IgG,孵育后加TMB显色,肉眼观察后,用平板扫描仪获取扫描图象,采用GenePixPro6.0软件分析灰度值。试验结果表明,该方法最低可检出10ng/mL的菲律宾蛤仔过敏原,片内平均变异系数(CV)为5.99%,片间为10.3%;香肠及蟹棒中3个不同浓度的加标回收率为73.54%~95.44%;4℃存放4个月内抗体微阵列玻片活性保持稳定。该方法不需要大型精密仪器,结果直观可见,可以发展为对多种过敏原进行同时检测,具有良好的实用和推广价值。 | 李小燕 李振兴 林洪 SAMEE Haider 张轶群 | 2010 | 水产学报2010，34，3： | 6 |
| 4 | Anti-allergic effects of ethanol extracts from brown seaweeds显示文摘Ethanol extracts of brown seaweeds from Pakistan and China were isolated and compared for their antiallergenic activities. They included Sargassum tennerimum (ST) and Sargassum cervicorne (SC) from Pakistan, and Sargassum gramini- folium turn (SG), Sargassum thunbergii (STH), and Laminaria japonica (LJ) from China. The ethanol extracts of these brown seaweeds were optimized at 85% (v/v) ethanol for the maximum yield of phlorotannin, an inhibitor against hyaluronidase. Total phlorotannins contained in the crude extracts were measured as 1.71% (SG), 0.74% (STH), 0.97% (LJ), 3.30% (SC), and 5.06% (ST). The 50% inhibitory concentrations (IC50) of Pakistani SC and ST were 109.5 and 21 μg/ml, respectively, lower than those of Chinese SG, STH, and LJ (134, 269, and 148 μg/ml, respectively). An antiallergic drug, disodium cromoglycate (DSCG), had an IC50=39 μg/ml, and a natural inhibitor of hyaluronidase, catechin, had an IC50=20 μg/ml. The IC50 of ST extract was found similar to that of catechin (21 vs 20 μg/ml) and lower than that of DSCG (21 vs 39 μg/ml). This suggests that ST is a potent inhibitor of hyaluronidase, indicating a promising future development of natural antiallergic medicines or functional foods. | Haider SAMEE Zhen-xing LI Hong LIN Jamil KHALID Yong-chao GUO | 2009 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2009，10，2： | 6 |
| 5 | 侏罗纪末至白垩纪非海相介形类生物地层学:回顾与展望显示文摘以非海相介形类为依据而建立的侏罗纪末至白垩纪的生物地层学,尤其是欧洲所谓'Purbeck-Wealden层段'(提塘阶顶部至巴列姆阶/阿普特阶底部)和全球同期沉积层的生物地层学建立已久,但这一生物地层学存有很多问题与局限性。本文对中生代晚期(聚焦于早白垩世)的非海相介形类生物地层学的基本原理、历史、目前进展、存在问题和前景进行了综述。因为介形类的繁殖、扩散与成种机制已有比较成熟的研究,所以介形类的生物地层学的应用潜力被认识已久。然而,全球不同地区中生代晚期的非海相介形类众多的研究积累已构成了一个丰富但常常混乱和矛盾的文献库。这些问题不仅存在于介形类的分类鉴定中,也见于关于古环境和系统发育的解释中。虽然地区性的盆地内的介形类生物地层学研究已产生了好结果,并可能能够用于局部地区的高精度对比。但是在进行地区间(盆地间至全球)的对比时,其实用性广遭怀疑。在过去的二十年间,许多学者采用了将今论古的古生物学研究方法,努力修订和更新中生代晚期的非海相介形类的生物地层学与古环境意义,从而促进了地区间生物地层学研究和对比的发展。古生物学家认识到,对于许多非海相介形类动物来讲,它们的分布和扩散不仅仅局限于单个的水系或较小的地理区域,而是和现生的非海相介形类一样,晚侏罗世至白垩纪的非海相介形类动物和它们的卵可被较大的动物或风长距离搬运,跨越迁移的屏障,进行扩散。鉴于以上事实,地区间的对比必须涉及两大内容:分类学的应用与古环境背景。缺乏适用于地区—全球的稳定和一致的分类学系统是进行正确对比的重要障碍。由于大量地方性分类命名、地方性特有动物的假设、与壳体特征相关的分类和生态型认识的混乱,以及对种内变异尺度的统一认识的缺乏,导致了对生物分异度的过高或过低的估量。非海相白垩纪介形类的地层记录受到诸多因素的影响:分类单元的演化与灭绝、扩散事件、当地的环境变化和地区性至全球的气候变迁。在生物地层学的应用中,我们可以通过不同手段去把握同时代的Cytheroidea,特别是Cypridoidea中具重要地层意义的Cypridea属及其亲近者(即CypridoideaMartin,1940)的分类单元的形态变异度。解释种内变异时需要格外谨慎。区分生物自生(内因)导致的变异(遗传的和形态的变异)和环境(外因)导致的变异(生态表型)是一大难题。比较保守的分类学观念(分类单元很少,但变异极大(分类单元中包含了多种生态表型))有助于不同古环境间的(生物地层)对比。另一方法是运用随着时间的古环境变化及其对介形类组合的组成的影响来进行(生物地层)对比。古生物工作者已在利用受环境控制的周期性介形类组合变化建立对比关系方面进行了大量有意义的尝试,但这些工作仍处在争议中。建立全球生物地层学方法,建立统一而持久的分类概念这一目标可以达到,但不可能在短期内实现。用现代的思想(概念)理解和研究非海相介形类的古生物学和古生物地理学及新资料将有助于修订工作的进展。尽管我们对中生代的非海相介形类的演化和分布的认识还很不全面,但目前我们已取得了可喜的进展。盆地间至大陆间的对比是否可行,早已不是问题。目前和未来的指导原则无疑是发展以介形类为基础,并与其他的年代地层学和地质年代学资料及方案相结合的从地区至全球范围的地层对比系统。因为我们正在迈向一个非海相晚中生代介形类生物地层学的重新解释和应用的新时代,我们必须承认我们还有许多东西需要学习。 | Benjamin SAMES David J.HORNE | 2012 | 地层学杂志2012，36，2： | 4 |
| 6 | Studies on the Specific Degranulation of Mast Cell Sensitized by Several Allergens in vitro显示文摘Food allergy is a major health issue worldwide. Mast cells play a very important role in the immediate hypersensitivity for which mast cell degranulation needs to be studied extensively. In this study, an approach was taken to study the characteristics of sensitized mast cell degranulation in vitro, which associated with the study of mast cells and animal models. BALB/c mice were immunized respectively by several food allergens, then blood and peritoneal mast cells were collected at different time points. A dynamic determination was carried out between mast cells and serumal IgE. Comparative analysis on sequential time points showed that there was a close coincidence between mast cell degranulation and IgE antibody titers in sensitized BALB/c mice. Furthermore, it is interesting that sensitized mast cells could implement specific degranulation against the challenges in vitro, but the closely tropomyosins induced mast cell degranulation displayed cross reactions. This is very similar to IgE resisting the allergens in vivo. The study disclosed some characteristics on mast cells, coming from sensitized BALB/c mice, degranulation in vitro. | Yongchao Guo Zhenxing Li Hong Lin Haider Samee Jamil Khalid | 2009 | Cellular & Molecular Immunology2009，6，2： | 3 |
| 7 | Optimization of Preparative Separation and Purification of Total Polyphenols from Sargassum tenerrimum by Column Chromatography显示文摘Polyphenols from the ethanol extracts of Sargassum tenerrimum (ST) with potent antiallergic effects were studied to optimize separation process through column chromatography. The adsorption and desorption characteristics of three widely used adsorbents: macroporous resin, silica gel, and polyvinylpolypyrrolidone (PVPP), were critically evaluated respectively and studied for the optimization of preparative separation of polyphenols. Static operations on these adsorbents showed that macroporous resin had the best adsorption and desorption capability among the three adsorbents. Dynamic adsorption and desorption with macroporous resin packed column were also conducted to optimize the parameters such as: with the optimal values shown in brackets, the concentration of extract solution (4 times diluted), pH value (6?7), adsorption speed (3 BV h-1, bed volumes/per hour), concentration of ethanol (80%), elution speed (3 BV h-1) and elution volume (7 BV). The chromatographic process so optimized gave a purity of 62.43% from the crude polyphenols, providing a promising basis for large scale preparation of bioactive polyphenols upon further scaling up tests. | Samee Haider LI Zhenxing LIN Hong Khalid Jamil | 2009 | Journal of Ocean University of China2009，8，4： | 3 |
| 8 | The Cosmic Dust in Suzhou Granite:Ablated Products of a Cometary Explosion | Hu Zhong-wei,Wang Er-kang,Wan Yu-qiuDepartement of Astronomy,Nanjing University,Nanjing 210093,China Department of Earth Sdence,Nanjing University,Nanjing 210093,China Cosmic dust has been collected in large number from deap-sea sediments,Greenland ice deposits,the stratosphere and space,of cosmic dust,some are the unmelted micrometeorite,and most are the ablated products of me-teoroids in the atmosphere.Cosmic dusts were recovered from two sites of the 1908 Tunguska explosion and the 1965 Revelstoks explosion Since 1987,a large number of microspherules have been extracted from Suzhou granite of China Their suface and section structures,mineral and chemical composition show that these microspherules are of the ablated cosmic dust.The microspherules occurred in the inner contact complex intrusion.It suggests that the microspherules may be products of the same event and were aggergated in some strata and then captured by the emplacement of granitic magma.Although the microspherules are similare to other ablated cosmic dusts,there are some diferences.Our calculated results of cometary motion through the atmosphere and explosion show that the microspherules may be the ablated dust of a comet with mass above 1015g at its explosion near the ground. | 1996 | 紫金山天文台台刊1996，15，3： | 2 |
| 9 | A V2I communication-based pipeline model for adaptive urban traffic light scheduling显示文摘Adaptive traffic light scheduling based on realtime traffic information processing has proven effective for urban traffic congestion management. However, fine-grained information regarding individual vehicles is difficult to acquire through traditional data collection techniques and its accuracy cannot be guaranteed because of congestion and harsh environments. In this study, we first build a pipeline model based on vehicle-to-infrastructure communication, which is a salient technique in vehicular adhoc networks. This model enables the acquisition of fine-grained and accurate traffic information in real time via message exchange between vehicles and roadside units. We then propose an intelligent traffic light scheduling method (ITLM) based on a “demand assignment” principle by considering the types and turning intentions of vehicles. In the context of this principle, a signal phase with more vehicles will be assigned a longer green time. Furthermore, a green-way traffic light scheduling method (GTLM) is investigated for special vehicles (e.g., ambulances and fire engines) in emergency scenarios. Signal states will be adjusted or maintained by the traffic light control system to keep special vehicles moving along smoothly. Comparative experiments demonstrate that the ITLM reduces average wait time by 34%-78% and average stop frequency by 12%-34% in the context of traffic management. The GTLM reduces travel time by 22%^44% and 30%-55% under two types of traffic conditions and achieves optimal performance in congested scenarios. | Libing WU Lei NIE Samee U. KHAN Osman KHALID Dan WU | 2019 | Frontiers of Computer Science2019，13，5： | 2 |
| 10 | Special Topic: Cretaceous greenhouse palaeoclimate and sea-level changes显示文摘Earth's climate has oscillated between greenhouse(warm)and icehouse(cold)modes throughout Earth history.At present,Earth is in the midst of an icehouse climate interval,despite the anthropogenic contribution to global warming and sea-level | XiuMian HU Michael WAGREICH Benjamin SAMES | 2017 | Science China Earth Sciences2017，60，1： | 2 |
| 11 | Neighbor finding techniques for image represented by Quadtree显示文摘 | Same H | 2000 | Computer Science2000，30，10： | 2 |
| 12 | Strategic alliance in a closed- loop supply chain, a case of manufacturer and econon-profit organization显示文摘 | Samee K Malegeat P | 2005 | Technovation2005，8，2： | 1 |
| 13 | Organic acids and their salts as dipping solutions to control Listeria monocytogenes inoculated following processing of sliced pork bologna stored at 4℃in vacuum packages显示文摘 | SAMELIS J SOFOS J N KAIN M L | 2001 | Journal of food protection2001，64，： | 1 |
| 14 | Activation-induced cell death vs passive macrophage-dependent deletion 显示文摘 | Gonzalo JA Baixeras E Gonzalez-Garcia A Differential in vivo effects of a superantigen and an antibody targeted to the same T cell receptor | 1994 | J Immunol1994，152，： | 1 |
| 15 | Influence of TiO2 and ZnO photocatalysts on adsorption mad degradation behaviour of Ervthrosine显示文摘 | Uddin M M Hasnat M A Samed A J F | 2007 | Dyes and Pigments2007，75，1： | 1 |
| 16 | A liquid-liquid extraction procedure followed by a low temperature purifi- cation step for the analysis of macrocyclic lactones in milk by liquid chromatography-tandem mass spectrometry and fluorescence detection显示文摘 | Sameness G Barreto F Hoff R B | 2011 | Anal Chim Acta2011，705，12： | 1 |
| 17 | Vascular and bowel complications during retroperitoneal laparoscopic surgery 显示文摘 | MERANEY A M SAMEE A GILL I S | 2002 | J Urol2002，168，5： | 1 |
| 18 | Skeletal and dental response to rapid maxillary expansion with 2- ver- sus 4-band appliances显示文摘 | Davidovitch M Efstathiou S Same O | 2005 | Am J Orthod Dentofacial Orthop2005，127，4： | 1 |
| 19 | Evaluation of the extem and type ot' bacterial contamination at diff'rent stages of processing ot' eol)ked ham 显示文摘 | Samelis J Kakouril A Remenhzis J | 2000 | Journal of Applied Microbiology2000，84，4： | 1 |
| 20 | Selective effect of theproduct type and the packaging conditions on the species of lactic acidbacteria dominating the spoilage microbial associations of cooked meatsat 4℃显示文摘 | SAMELIS J KAKOURI A REMENTZIS J | 2000 | Food Microbiology2000，17，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员