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| 1 | Ileocecal valve dysfunction in small intestinal bacterial overgrowth: A pilot study显示文摘AIM: To explore whether patients with a defective ileocecal valve (ICV)/cecal distension reflex have small intestinal bacterial overgrowth. METHODS: Using a colonoscope, under conscious sedation, the ICV was intubated and the colonoscope was placed within the terminal ileum (TI). A manometry catheter with 4 pressure channels, spaced 1 cm apart, was passed through the biopsy channel of the colonoscope into the TI. The colonoscope was slowly withdrawn from the TI while the manometry catheter was advanced. The catheter was placed across the ICV so that at least one pressure port was within the TI, ICV and the cecum respectively. Pressures were continuously measured during air insufflation into the cecum, under direct endoscopic visualization, in 19 volunteers. Air was insufflated to a maximum of 40 mmHg to prevent barotrauma. All subjects underwent lactulose breath testing one month after the colonoscopy. The results of the breath tests were compared with the results of the pressures within the ICV during air insufflation. RESULTS: Nineteen subjects underwent colonoscopy with measurements of the ICV pressures after intubation of the ICV with a colonoscope. Initial baseline readings showed no statistical difference in the pressures of the TI and ICV, between subjects with positive lactulose breath tests and normal lactulose breath tests. The average peak ICV pressure during air insufflation into the cecum in subjects with normal lactu-lose breath tests was significantly higher than cecal pressures during air insufflation (49.33 ± 7.99 mmHg vs 16.40 ± 2.14 mmHg, P = 0.0011). The average percentage difference of the area under the pressure curve of the ICV from the cecum during air insufflations in subjects with normal lactulose breath tests was significantly higher (280.72% ± 43.29% vs 100% ± 0%, P = 0.0006). The average peak ICV pressure during air insufflation into the cecum in subjects with positive lactulose breath tests was not significantly different than cecal pressures during air insufflation 21.23 ± 3.52 mmHg vs 16.10 ± 3.39 mmHg. The average percentage difference of the area under the pressure curve of the ICV from the cecum during air insufflation was not significantly different 101.08% ± 7.96% vs 100% ± 0%. The total symptom score for subjects with normal lactulose breath tests and subjects with positive lactu-lose breath tests was not statistically different (13.30 ± 4.09 vs 24.14 ± 6.58). The ICV peak pressures during air insufflations were significantly higher in subjects with normal lactulose breath tests than in subjects with positive lactulose breath tests (P = 0.005). The average percent difference of the area under the pressure curve in the ICV from cecum was significantly higher in subjects with normal lactulose breath tests than in subjects with positive lactulose breath tests (P = 0.0012). Individuals with positive lactulose breath tests demonstrated symptom scores which were significantly higher for the following symptoms: not able to finish normal sized meal, feeling excessively full after meals, loss of appetite and bloating. CONCLUSION: Compared to normal, subjects with a positive lactulose breath test have a defective ICV cecal distension reflex. These subjects also more commonly have higher symptom scores. | Larry S Miller Anil K Vegesna Aiswerya Madanam Sampath Shital Prabhu Sesha Krishna Kotapati Kian Makipour | 2012 | World Journal of Gastroenterology2012，18，46： | 3 |
| 2 | Factors affecting gas slippage in tight sandstones of cretaceous age in the Uinta basin 显示文摘 | Sampath K Keighin C W | 1982 | JPT1982，，： | 1 |
| 3 | Decay and half-life period of online citations cited in open access journals 显示文摘 | Sampath Kumar B Manoj Kumar K | 2012 | The International Information&Library Review2012，，： | 1 |
| 4 | An economic evaluation of smallholder irrigation systems in Zimbabwe 显示文摘 | MAKOMBE G SAMPATH R K | 1998 | Water Resour Dev1998，1，： | 1 |
| 5 | Desirable feathers of non-chromate conversion coating process显示文摘 | Sampath K | 2004 | Plating and Surface Finishing2004，91，3： | 1 |
| 6 | Effect of urea and by-products on the in vitro fermentation of untreated and urea treated finger millet straw显示文摘 | Sampath K T Wood C D Prasad C S | 1995 | J Sci Food Agric1995，67，： | 1 |
| 7 | Desirable feathers of non-chromate conversion coating process显示文摘 | Sampath K | 2004 | Plating and Surface Finishing2004，91，3： | 1 |
| 8 | Current trends in the diagnosis and management of renal nutcracker syndrome : a review显示文摘 | Ahmed K Sampath R Khan MS | 2006 | Eur J Vasc Endovasc Surg2006，31，4： | 1 |
| 9 | Administration of yeast glucan enhances survival and some non-specific and specific immune parameters in carp (cyprinus carpio) infected with Aeromonas hydrophila 显示文摘 | Selvaraj V Sampath K Sekar V | 2005 | Fish and shellfish Immunology2005，19，： | 1 |
| 10 | An alkaline direct borohydride fuel cell with hydrogen peroxide as oxidant 显示文摘 | CHOUDHURY N A RAMAN R K SAMPATH S | 2005 | Journal of Power Sources2005，143，12： | 1 |
| 11 | Electrochemical reduction of oriented graphene oxide films: An in situ raman spectroelec- trochemical study显示文摘 | Ramesha G K Sampath S | 2009 | J Phys Chem C2009，113，19： | 1 |
| 12 | Metallurgical Model Speeds Development of GMA Welding Wire for HSLA Steel 显示文摘 | Sampath K Green R S Civis D A | 1995 | Welding Journal1995，74，12： | 1 |
| 13 | An index for measuring the performance of irrigation management systems with an application显示文摘 | Seckler D Sampath R K Raheja S K | 1998 | Water Resources Bulletin1998，24，4： | 1 |
| 14 | Identification of type I receptors for osteogenic protein - 1 and bone morphogenetic protein - 4 显示文摘 | Ten Dijke P Yamashita H Sampath T K | 1994 | J Biol Chem1994，269，16： | 1 |
| 15 | 显示文摘 | Sivakumar M Sampath Kumart T S Shantha K L | 1996 | Biomaterials1996，17，17： | 1 |
| 16 | Preliminary report on the effects of feeding frequency in Channa striatus 显示文摘 | Sampath K | 1984 | Aquaculture1984，40，： | 1 |
| 17 | Electrochemical capacitors with plasticized gel-polymer electrolytes显示文摘 | MITRA S SHUKLA A K SAMPATH S | 2001 | Power Sources2001，101，： | 1 |
| 18 | Sublethal effects of phosphamidon and methyl parathi- on on food intake, growth and conversion efficiency of the fish Oreochromis mossambicus 显示文摘 | Shanmugavel S Sampath K Sivakumar V | 1988 | Environment and Ecology (Kalyani)1988，2，6： | 1 |
| 19 | Conserved left- right asymmetry of nodal expression and alterations in murine situs inversus显示文摘 | Lowe LA Supp DM Sampath K | 1996 | Nature1996，381，： | 1 |
| 20 | Conserved left-right asymmetry of Nodal expression and alterations in murine situs illversus 显示文摘 | Lowe LA Supp DM SamPath K | 1996 | Na- ture1996，381，： | 1 |
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