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| 1 | NCB-02 (standardized Curcumin preparation) protects dinitrochlorobenzene-induced colitis through down-regulation of NFκ-B and iNOS显示文摘AIM: To evaluate the efficacy and mechanism of action of NCB-02, a standardized Curcumin preparation, against 2, 4-dinitrochlorobenzene (DNCB)-induced ulcerative colitis in rats. METHODS: Ulcerative colitis was induced in male rats by sensitizing with topical application of DNCB in acetone for 14 d and intra-colonol challenge with DNCB on day 15. A separate group of animals with vehicle treatment in similar fashion served as control group. Colitis rats were divided into different groups and treated with NCB-02 at doses of 25, 50 and 100 mg/kg b.wt p.o. for 10 d. Sulfasalazine at a dose of 100 mg/kg b.wt for 10 d served as a reference group. On day 10 after respective assigned treatment, all the animals were euthanized and the length of the colon, weight of entire colon and distal 8 cm of the colon were recorded. The distal part of the colon was immediately observed under a stereomicroscope and the degree of damage was scored. Further distal 8 cm of the colon was subject to the determination of colonic myeloperoxidase (MPO), lipid peroxidation (LPO) and alkaline phosphatase (ALP) activities. A small piece of the sample from distal colon of each animal was fixed in 10% neutral buffered formalin and embedded in paraffin wax and sectioned for immunohistochemical examination of NFκ-B and iNOS expression. RESULTS: NCB-02 showed a dose dependent protection against DNCB-induced alteration in colon length and weight. NCB-02 treatment also showed a dose dependent protection against the elevated levels of MPO, LPO and ALP, induced by DNCB. NCB-02 demonstrated a significant effect at a dose of 100 mg/kg b.wt., which was almost equipotent to 100 mg/kg b.wt. of sulfasalazine. Treatment with sulfasalazine and curcuminat a dose of 100 mg/kg b.wt. inhibited the DNCB-induced overexpression of NFκ-B and iNOS in the colon. CONCLUSION: Curcumin treatment ameliorates colonic damage in DNCB-induced colitic rats, an effect associated with an improvement in intestinal oxidative stress and downregulation of colonic NFκ-B and iNOS expression. | MV Venkataranganna Md Rafiq S Gopumadhavan Ghouse Peer UV Babu SK Mitra | 2007 | World Journal of Gastroenterology2007，13，7： | 12 |
| 2 | 白屈菜抗肝细胞毒的活性显示文摘白屈菜是罂粟科的多年生落叶植物,一般生长于欧亚大陆。其乙醇提取物用作顺势疗法(homocopathy)已为众所周知,在中世纪将其作为许多疾病的治疗药,并公认其有较好的疗效。曾报道白屈菜的提取物可用作利胆药和解痉药,而用作顺势疗法则可追溯到对肝脏疾病的治疗。本文试验了白屈菜提取物对四氯化碳诱发的实验性肝细胞损害的保护作用。 | Mitra S 李汉保 | 1993 | 药学进展1993，17，1： | 2 |
| 3 | Quantitative analysis of all major forms of sulfur in coal by x-ray absorption fine structure spectroscopy 显示文摘 | Huffman G P Mitra S Huggins F E | 1991 | Energy and Fuels1991，5，4： | 1 |
| 4 | Formation of epitaxial and polycrystalline films of the electron doped system La1-xCexMnO3 through pulsed laser deposition 显示文摘 | Mitra C Raychaudhuri P Dhar S K Nigam A K Pinto R | 2001 | Journal of Magnetism and Magnetic Materials2001，22，： | 1 |
| 5 | Effect of rare earth elements on microstmcture and oxidation behaviour in TIG weldments of MS1316L stainless steel 显示文摘 | Samanta S K Mitra S K Pal T K | 2006 | Materials Science and Engineering: A2006，430，2： | 1 |
| 6 | Multisensor image fusion using the wavelet transform 显示文摘 | LI H MANJUNATH B S MITRA S K | 1995 | Graph Models Image Process1995，57，3： | 1 |
| 7 | Rough fuzzy mlp: knowledge encoding and classification 显示文摘 | Banerjee M Mitra S and Pal S K | 1998 | IEEE Transactions on Neural Networks1998，9，6： | 1 |
| 8 | Neuro-fuzzy rule generation:survey in soft computing framework显示文摘 | Hayashi Y | 2000 | IEEE Trans Neural Networks2000，11，3： | 1 |
| 9 | A clinicopathological study of acute necrotizing jejunoileitis 显示文摘 | Mathur M Agarwala S Mitra DK | 2002 | Pediatr surg Int2002，18，： | 1 |
| 10 | Focal adhesion kinase: in command and control of cell motility 显示文摘 | Mitra S K Hanson D A Schlaepfer D D | 2005 | Nat Rev Mol Cell Biol2005，6，1： | 1 |
| 11 | SOX5 and SOX6 are needed to develop and maintain source, columnar, and hypertrophic chondrocytes in the cartilage growth plate显示文摘 | Smits P Dy P Mitra S | 2003 | Development2003，130，： | 1 |
| 12 | Application of an expert system to the design of furnace of circulating fluided bed boiler显示文摘 | BASU P MITRA S | 1994 | Journal of Engineering for Gas Turbines and Power1994，116，： | 1 |
| 13 | Image resizing in the compressed domain using subband DCT 显示文摘 | Mukherjee J Mitra S K | 2002 | IEEE Transactions on Circuits and Systems for Video Technology2002，12，6： | 1 |
| 14 | Development of a novel formulation containing poly (D, L-lactide-coglycolide) microspheres dispersed in PLGA-PEG-PLGA gel for sustained delivery of ganciclovir显示文摘 | Duvvuri S Janoria K G Mitra A K | 2005 | Journal of Controlled Release2005，108，2： | 1 |
| 15 | Saturation-based adaptive inverse gradient interpolation for Bayer pattern images显示文摘 | Cai C Yu T H Mitra S K | 2001 | IEEE Proceedings-Vision2001，148，3： | 1 |
| 16 | Supply chain integration and shareh- older value: Evidence from consortium based industry ex- changes显示文摘 | Mitra S Singhal V | 2008 | Journal of Operations Management2008，26，1： | 1 |
| 17 | Competition in remanufaeturing and the effects of government subsidies显示文摘 | MITRA S WEBSTER S | 2008 | International Journal of Production Economics2008，111，2： | 1 |
| 18 | Competition in remanufacturing and the effects of government subsidies显示文摘 | MITRA S WEBSTER S | 2008 | International Journal of Production Economics2008，111，2： | 1 |
| 19 | A 700year record of combus-tion-derived pollution in northern Spain : tools to identify the Ho-locene/ Anthropocene transition in coastal environments 显示文摘 | Leorri E Mitra S Irabien MJ | 2013 | Sci TotalEnviron2013，，： | 1 |
| 20 | Competitive strategy in remanufacturing and the impact of take-back laws 显示文摘 | Webster S Mitra S | 2007 | Journal of Operations Management2007，25，6： | 1 |
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