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| 1 | Comparison of multichannel intraluminal impedance-pH monitoring and reflux scintigraphy in pediatric patients with suspected gastroesophageal reflux显示文摘AIM To evaluate the agreement of multichannel intraluminal impedance-p H monitoring(MII-p HM) and gastroesophageal reflux scintigraphy(GES) for the diagnosis of gastroesophageal reflux disease. METHODS Seventy-five consecutive patients with suspectedgastroesophageal reflux disease(GERD) underwent 24-h combined MII-p HM recording and one hour radionuclide scintigraphy during the course of the MIIpH M study. Catheters with 6 impedance channels and 1 p H sensor were placed transnasally. Impedance and p H data analysis were performed automatically and manually. For impedance monitoring, reflux was defined as a retrograde 50% drop in impedance, starting distally and propagating retrogradely to at least the next two more proximal measuring channels. Reflux index(RI, percentage of the entire record that esophageal p H is < 4.0) greater than 4.2% for p HM and number of refluxes more than 50 for 24 h for MII were accepted as positive test results. At scintigraphy, 240 frames of 15 seconds duration were acquired in the supine position. Gastroesophageal reflux was defined as at least one reflux episode in the esophagus. After scintigraphic evaluation, impedance-pH recordings and scintigraphic images were evaluated together and agreement between tests were evaluated with Cohen's kappa.RESULTS Sufficient data was obtained from 60(80%) patients(34 male, 56.7%) with a mean age of 8.7 ± 3.7 years(range: 2.5-17.3 years; median: 8.5 years). Chronic cough, nausea, regurgitation and vomiting were the most frequent symptoms. The mean time for recording of MII-pH M was 22.8 ± 2.4 h(range: 16-30 h; median: 22.7 h). At least one test was positive in 57(95%) patients. According to diagnostic criteria, GERD was diagnosed in 34(57.7%), 44(73.3%), 47(78.3%) and 51(85%) patients by means of p HM, MII, GES and MII-p HM, respectively. The observed percentage agreements/κ values for GES and p HM, GES and MII, GES and MII-p HM, and MII and p HM are 48.3%/-0.118; 61.7%/-0.042; 73.3%/0.116 and 60%/0.147, respectively. There was no or slight agreement between GES and p HM alone, MII alone or MII-p HM. p H monitoring alone missed 17 patients compared to combined MII-p HM. The addition of MII to pH monitoring increased the diagnosis rate by 50%.CONCLUSION No or slight agreement was found among p H monitoring, MII monitoring, MII-pH monitoring and GES for the diagnosis of gastroesophageal reflux disease. | Nuray Uslu Kizilkan Murat Fani Bozkurt Inci Nur Saltik Temizel Hülya Demir Aysel Yüce Biray Caner Hasan Ozen | 2016 | World Journal of Gastroenterology2016，22，43： | 2 |
| 2 | A clinical and EEG study on idiopathic partial epilepsies with evolution into ESES spectrum disorders 显示文摘 | Saltik S Uluduz D Cokar O | 2005 | Epilepsia2005，46，4： | 1 |
| 3 | A retrospective analisys of patients with febrile seizures followed by epilepsy显示文摘 | Saltik S Angay A Ozkara C | 2003 | Seizure2003，12，： | 1 |
| 4 | Acute liver failure in children: 20-year experience显示文摘 | Baris Z Saltik TIN Uslu N | 2012 | Turk J Gastroen terol2012，23，2： | 1 |
| 5 | Informative value of MRI and EEG in the prognosis of infantile spasms显示文摘 | Kocer N Dervent A | 2002 | Epilepsia2002，43，3： | 1 |
| 6 | Hoffmanng syndrome and pitui- tary hyperplasia in an adolescent secondary to Hashimoto thyroiditis 显示文摘 | Cebeci AN G0veu A Saltik S | 2013 | J Pediatr Endocrinol Metab2013，26，78： | 1 |
| 7 | Acute liver failure in children: 20-year experience 显示文摘 | Baris Z Saltik Temzel IN Uslu N | 2012 | Turk J Gastroenterol2012，23，2： | 1 |
| 8 | Relationships between left heart chamber dilatation on echocardiography and left- to-right ventricle shunting quantified by cardiac catheterization in children with entricular septal defects 显示文摘 | GOKALP S GULER EROGLU A SALTIK L | 2014 | Pediatr Cardiol2014，35，4： | 1 |
| 9 | A clinical and EEG study on idiopathic parital epilepsies with evolution into ESES spectrum disorders 显示文摘 | Saltik S Uluduz D Cokar O | 2005 | Epilepsia2005，46，4： | 1 |
| 10 | Activation of heat-shock response by an adenovirus is essential for virus replication显示文摘 | Saltik M Chiocca S | 2000 | Nature2000，407，6801： | 1 |
| 11 | Aortic valve prolapse and aortic regurgitation in patients with ventricular septal defect显示文摘 | EROGLU A G OZTUNC F SALTIK L | 2003 | Pediatr Cardiol2003，24，： | 1 |
| 12 | Two new general p-valent integral operators显示文摘 | SALTIK G DENIZ E KADIOGLU E | 2010 | Mathematical and Computer Modelling2010，52，： | 1 |
| 13 | A clinical and EEG study on idiopathic partial epilepsies with evolution into ESES spectrum disor- ders 显示文摘 | Saltik S Uluduz D Cokar O | 2005 | Epilepsia2005，46，4： | 1 |
| 14 | A clinical and EEG study on idiopathic partial epilepsies with evolution into ESES spectrum disorders 显示文摘 | Saltik S Uluduz D Cokar O | 2005 | Epilepsia2005，46，4： | 1 |
| 15 | Lipopolysaccharide is a frequent contaminant of plasmid DNA preparations and can be toxic to primary human cells in the presence of adenovirus 显示文摘 | COTTEN M BAKER A SALTIK M | 1994 | Gene Therapy1994，1，4： | 1 |
| 16 | Mutational analysis of the avain adenovirus CELO, which provides a basis for gene delivery vector 显示文摘 | Michou A I Lehrmann H Saltik M et ai | 1999 | J Virol1999，73，2： | 1 |
| 17 | Evolution of Ventricular Septal Defect with Special Reference to Spontaneous Closure Rate, Subaortic Ridge and Aortic Valve Prolapse显示文摘 | A.G. Eroglu F. ?ztun? L. Saltik S. Bakari S. Dedeoglu G. Ahunbay | 2003 | Pediatric Cardiology2003，，1： | 1 |
| 18 | Subnormal growth in children with Helicobacter pylori infection显示文摘 | Demir H Saltik IN Kocak N | 2001 | Arch Dis Child2001，84，： | 1 |
| 19 | Autoimmune hepatitis 显示文摘 | Ozen H Kocak N Saltik IN | 2001 | Indian J Pediatr2001，68，8： | 1 |
| 20 | Clinical and EEG study on idio- pathic Parital epilepsies with evolition into ESES spectrum dis- orders显示文摘 | Saltik luduz d Cokar O | 2005 | Epilepsia2005，46，4： | 1 |
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