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| 1 | Helicobacter pylori infection in subjects negative for high titer serum antibody显示文摘AIM To investigate the clinicopathological features of the patients testing negative for high titer serum antiHelicobacter pylori(H. pylori) antibody.METHODS The antibody titers were measured using antigens derived from Japanese individuals. ^(13)C-urea breath test-positive individuals were defined as having H. pylori infection. We investigated the demographic characteristics, laboratory data, endoscopic findings including Kyoto classification of gastritis, and histology in negative-high titer patients without H. pylori eradication therapy. Kyoto classification consisted of scores for gastric atrophy, intestinal metaplasia, enlarged folds, nodularity, and redness.RESULTS Of the 136 subjects enrolled, 23(17%) had H. pylori infection. Kyoto classification had an excellent area under the receiver operating characteristics curve(0.886, 95% confidence interval: 0.803-0.968, P = 3.7 × 10^(-20)) for predicting H. pylori infection with a cutoff value of 2. Further, Kyoto classification, H. pylori density, and neutrophil activity had high accuracies(89.7%, 96.3%, and 94.1%, respectively). Kyoto classification was independent of the demographic and laboratory parameters in multivariate analysis.CONCLUSION Endoscopic Kyoto classification of gastritis is a useful predictor of H. pylori infection in negative-high titer antibody patients. | Osamu Toyoshima Toshihiro Nishizawa Masahide Arita Yosuke Kataoka Kosuke Sakitani Shuntaro Yoshida Hiroharu Yamashita Keisuke Hata Hidenobu Watanabe Hidekazu Suzuki | 2018 | World Journal of Gastroenterology2018，24，13： | 9 |
| 2 | Serum anti-Helicobacter pylori antibody titer and its association with gastric nodularity,atrophy,and age:A cross-sectional study显示文摘AIM To clarify the role of serum anti-Helicobacter pylori(H. pylori) antibody titers in gastric cancer.METHODS In this cross-sectional study, the effect of patients' baseline characteristics and endoscopic findings on their serum antibody titers were assessed. We evaluated consecutive patients who underwent esophagogastroduodenoscopy and their first evaluation for H. pylori infection using a serum antibody test. We excluded patients with a history of eradication therapy. The participants were divided into four groups according to their E-plate serum antibody titer. Patients with serum antibody titers < 3, 3-9.9, 10-49.9, and ≥ 50 U/m L were classified into groups A, B, C, and D, respectively. RESULTS In total, 874 participants were analyzed with 70%, 16%, 8.7%, and 5.1% of them in the groups A, B, C, and D, respectively. Patients in group C were older than patients in groups A and B. Gastric open-type atrophy, intestinal metaplasia, enlarged folds, diffuse redness, and duodenal ulcers were associated with a high titer. Regular arrangements of collecting venules, fundic gland polyps, superficial gastritis, and gastroesophageal reflux disease were related to a low titer. Multivariate analysis revealed that nodularity(P = 0.0094), atrophy(P = 0.0076), and age 40-59 years(vs age ≥ 60 years, P = 0.0090) were correlated with a high serum antibody titer in H. pylori-infected patients. Intestinal metaplasia and atrophy were related to age ≥ 60 years in group C and D.CONCLUSION Serum antibody titer changes with age, reflects gastric mucosal inflammation, and is useful in predicting the risk of gastric cancer. | Osamu Toyoshima Toshihiro Nishizawa Kosuke Sakitani Tadahiro Yamakawa Yoshiyuki Takahashi Nobutake Yamamichi Keisuke Hata Yasuyuki Seto Kazuhiko Koike Hidenobu Watanabe Hidekazu Suzuki | 2018 | World Journal of Gastroenterology2018，24，35： | 9 |
| 3 | Enlarged folds on endoscopic gastritis as a predictor for submucosal invasion of gastric cancers显示文摘BACKGROUND Accurate diagnosis of the depth of gastric cancer invasion is crucial in clinical practice.The diagnosis of gastric cancer depth is often made using endoscopic characteristics of the tumor and its margins;however,evaluating invasion depth based on endoscopic background gastritis remains unclear.AIM To investigate predicting submucosal invasion using the endoscopy-based Kyoto classification of gastritis.METHODS Patients with gastric cancer detected on esophagogastroduodenoscopy at Toyoshima Endoscopy Clinic were enrolled.We analyzed the effects of patient and tumor characteristics,including age,sex,body mass index,surveillance endoscopy within 2 years,current Helicobacter pylori infection,the Kyoto classification,and Lauren’s tumor type,on submucosal tumor invasion and curative endoscopic resection.The Kyoto classification included atrophy,intestinal metaplasia,enlarged folds,nodularity,and diffuse redness.Atrophy was characterized by non-reddish and low mucosa.Intestinal metaplasia was detected as patchy whitish or grayish-white flat elevations,forming an irregular uneven surface.An enlarged fold referred to a fold width≥5 mm in the greater curvature of the corpus.Nodularity was characterized by goosebump-like multiple nodules in the antrum.Diffuse redness was characterized by uniform reddish nonatrophic mucosa in the greater curvature of the corpus.RESULTS A total of 266 gastric cancer patients(mean age,66.7 years;male sex,58.6%;mean body mass index,22.8 kg/m2)were enrolled.Ninety-three patients underwent esophagogastroduodenoscopy for surveillance within 2 years,and 140 had current Helicobacter pylori infection.The mean Kyoto score was 4.54.Fifty-eight cancers were diffuse-type,and 87 cancers had invaded the submucosa.Multivariate analysis revealed that low body mass index(odds ratio 0.88,P=0.02),no surveillance esophagogastroduodenoscopy within 2 years(odds ratio 0.15,P<0.001),endoscopic enlarged folds of gastritis(odds ratio 3.39,P=0.001),and Lauren’s diffuse-type(odds ratio 5.09,P<0.001)were independently associated with submucosal invasion.Similar results were obtained with curative endoscopic resection.Among cancer patients with enlarged folds,severely enlarged folds(width≥10 mm)were more related to submucosal invasion than mildly enlarged folds(width 5-9 mm,P<0.001).CONCLUSION Enlarged folds of gastritis were associated with submucosal invasion.Endoscopic observation of background gastritis as well as the lesion itself may help diagnose the depth of cancer invasion. | Osamu Toyoshima Shuntaro Yoshida Toshihiro Nishizawa Akira Toyoshima Kosuke Sakitani Tatsuya Matsuno Tomoharu Yamada Takashi Matsuo Hayato Nakagawa Kazuhiko Koike | 2021 | World Journal of Gastrointestinal Endoscopy2021，13，9： | 2 |
| 4 | Kyoto classification in patients who developed multiple gastric carcinomas after Helicobacter pylori eradication显示文摘BACKGROUND Endoscopic Kyoto classification predicts gastric cancer risk;however,the score in the patients with primary gastric cancer after Helicobacter pylori(H.pylori)eradication therapy is unknown.AIM To elucidate the Kyoto classification score in patients with both single gastric cancer and multiple gastric cancers developed after H.pylori eradication.METHODS The endoscopist recorded the Kyoto classification at the endoscope and the Kyoto classification score at the time of the first diagnosis of gastric cancer after H.pylori eradication.The score was compared between single gastric cancer group and multiple gastric cancers group.RESULTS The Kyoto score at the time of diagnosis of 45 cases of gastric cancer after H.pylori eradication was 4.0 points in average.The score was 3.8 points in the single gastric cancer group,and 5.1 points in the multiple gastric cancers group.The multiple group had a significantly higher score than the single group(P=0.016).In the multiple gastric cancers group,all the patients(7/7)had 5 or higher Kyoto score,while in single gastric cancer group,the proportion of patients with a score of 5 or higher was less than half,or 44.7%(17/38).CONCLUSION Patients diagnosed with gastric cancer after H.pylori eradication tended to have advanced gastritis.In particular,in cases of multiple gastric cancers developed after H.pylori eradication,the endoscopic Kyoto classification score tended to be 5 or higher in patients with an open type atrophic gastritis and the intestinal metaplasia extended to the corpus. | Kosuke Sakitani Toshihiro Nishizawa Akira Toyoshima Shuntaro Yoshida Tatsuya Matsuno Tomoharu Yamada Masatoshi Irokawa Yoshiyuki Takahashi Yousuke Nakai Osamu Toyoshima Kazuhiko Koike | 2020 | World Journal of Gastrointestinal Endoscopy2020，12，9： | 2 |
| 5 | Analysis of the temperature characteristics in polycrystalline Si solar cells using modified equivalent circuit model显示文摘 | Nishioka K Sakitani N Kurobe K | 2003 | Japanese Journal of Applied Physics Part 1:Regular Papers Short Notes & Review Papers2003，42，12： | 1 |
| 6 | Anti-IgE therapy to Kimu- ra's disease a pilot study显示文摘 | Nonaka M Sakitani E Yoshihara T | 2014 | Auris Nasus Larynx2014，41，4： | 1 |
| 7 | Overoxpression of midkine in lung tumors induced by N-nitrosobis(2-hydroxypropyl )amine in rats and its increase with progression显示文摘 | Tsutsumi M Kadomatsu K | 1999 | Carcinogenesis1999，20，3： | 1 |
| 8 | Role of interleukin-32 in Helicobacter pylori-induced gastric inflammation显示文摘 | Sakitani K Hirata Y Hayakawa Y | 2012 | Infect Immun2012，80，11： | 1 |
| 9 | Gastric cancer risk according to the distribution of intestinal metaplasia and neu- trophil infiltration 显示文摘 | Sakitani K Hirata Y Watabe H | 2011 | J Gastroenterol Hepatol2011，26，10： | 1 |
| 10 | Analysis of coaxial collinear antenna:Recurrence formula of voltages and admittances at connections显示文摘 | Akihide Sakitani Shigeru Egashira | 1991 | IEEE Trans on AP1991，39，1： | 1 |
| 11 | Differential regulation of activin A for hepatocyte growth and fibronectin synthesis in rat liver injury显示文摘 | Masataka Date Koichi Matsuzaki Masanori Matsushita Yoshiya Tahashi Kazushige Sakitani Kyoichi Inoue | 2000 | Journal of Hepatology2000，，2： | 1 |
| 12 | Overepression of midkine in lung tumors induced by N-nitrosobis (2-hydroxyropy) amine in rats and its increase with progression 显示文摘 | Sakitani H Tsutsumi M Kadomatsu K | 1999 | Carcinogenrsis1999，20，3： | 1 |
| 13 | Interleukin-1βmarkedly stimulates nitric oxide formation in the absence of other cytokines or lipopolysaccharide in primary cultured rat hepatocytes but not in Kupffer cells显示文摘 | Kitade H Sakitani K Indue K | 1996 | Hepatology1996，23，3： | 1 |
| 14 | Differential regulation of activin A for hepatocyte growth and fibronectin synthesis in rat liver injury显示文摘 | Masataka Date Koichi Matsuzaki Masanori Matsushita Yoshiya Tahashi Kazushige Sakitani Kyoichi Inoue | 2000 | Journal of Hepatology2000，，2： | 1 |
| 15 | Anti-inflammatory drug sodium salicylate inhibits nitric oxide formation induced by interleukin-1β at a translatioual step,but not a transcriptional step in hepatocytes显示文摘 | Sakitani K Kitade H Inoue K | 1997 | Hepatology1997，25，2： | 1 |
| 16 | Gastric cancer risk according to the distribution of intestinal metaplasia and neutrophil infiltration 显示文摘 | Sakitani K Hirata Y Watabe H | 2011 | J Gastroenterol Hepatol2011，26，10： | 1 |
| 17 | Anti-IgE therapy to Kimura' s disease: a pilot study显示文摘 | Nonaka M Sakitani E Yoshibara T | 2014 | Auris Nasus Larynx2014，41，4： | 1 |
| 18 | Analysis of Coaxial Collinear Antenna: Recurrence Formula of Voltages and Admittances at Connections显示文摘 | Sakitani A Egashira S | 1991 | IEEE Trans on AP1991，39，1： | 1 |
| 19 | Increased telomerase activity and absence of p53 mutation in oligoastrocytomas induced by N-ethyl-N-nitrosourea in rats显示文摘 | Sakitani H Tsujiuchia T Kobitsub K | 1998 | Cancer Lett1998，126，： | 1 |
| 20 | Immunosuppressant FK506 inhibits inducible nitric oxide synthase gene expression at a step of NF-κB activation in rat hepatocytes显示文摘 | Kaibori M Sakitani K Oda M | 1999 | J Hepatol1999，30，6： | 1 |
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