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| 1 | Distribution and risk factors of hand, foot, and mouth disease in Changchun, northeastern China显示文摘Hand,foot,and mouth disease(HFMD)is a public health problem,and there have been increasing numbers of outbreaks in China's Mainland since 2008.Over17,000 HFMD cases have been reported in Changchun between 2008 and 2011.This study characterized the temporal and spatial distribution of the disease and identified the risk factors for HFMD.The main findings were as follows:(i)there were significant differences in HFMD incidence among age groups,with 86.8%of reported cases in children younger than 5 years old,and boys showed a higher incidence than girls(\6 years);(ii)The disease affected the whole region and spanned a large geographic area,but there was a higher incidence in urban areas(median=242 per 10,000 persons)and urban–rural border areas(median=135 per 10,000 persons),compared with rural areas(median=75 per 10,000 persons);and(iii)the incidence of HFMD in Changchun was significantly associated with the distance to the nearest freeway,GDP per capita,and the type of township. | Li Yan Xinlou Li Yaqin Yu Sake J.de Vlas Yapin Li Dandan Wang Yanli Li Yuan Yin Jing Wu Hong Liu Hong Yang Bo Li Liqun Fang Wuchun Cao | 2014 | Chinese Science Bulletin2014，59，5： | 7 |
| 2 | MAP3K1 and MAP2K4 mutations are associated with sensitivity to MEK inhibitors in multiple cancer models显示文摘激活 mitogen 的蛋白质 kinase (MAPK ) 的激活小径在癌症是经常的。药发展努力在这条小径集中于 kinases,最尤其是在皇家空军和 MEK 上。我们这里证明 MEK 抑制激活通过 DUSP4 的抑制发信号的 JNK6 月,导致她的受体酷氨酸 Kinases 的激活。这面对药刺激 MAPK 小径,从而弄钝 MEK 抑制的效果。失去了 MAP3K1 或 MAP2K4 的癌症没能因而激活 JNK-JUN. ,在 MAP3K1 或 MAP2K4 的 loss-of-function 变化由在 MEK 抑制之上停用 JNK-JUN-mediated 反馈循环授与敏感到 MEK 抑制。在 168 个耐心的导出的异种皮移植(PDX ) 肿瘤的一块面板, MAP3K1 和 MAP2K4 变化地位是对 MEK 抑制的反应的一个强壮的预言者。我们的调查结果建议在 MAP3K1 或 MAP2K4 有变化的癌症,在胸,前列腺和冒号的肿瘤经常,可以对 MEK 禁止者作出回应。我们的调查结果也建议 MAP3K1 和 MAP2K4 是在有 MEK 禁止者的联合的潜在的药目标,尽管有他们被肿瘤 suppressor 基因编码的事实。 | Zheng Xue Daniel J. Vis Alejandra Bruna Tonci Sustic Sake van Wageningen Ankita Sati Batra Oscar M. Rueda Evert Bosdriesz Carlos Caldas Lodewyk F. A. Wessels Rene Bernardt | 2018 | Cell Research2018，28，7： | 5 |
| 3 | Burden of onchocerciasis-associated epilepsy:first estimates and research priorities显示文摘Background:Since the 1990s,evidence has accumulated of an increased prevalence of epilepsy in onchocerciasisendemic areas in Africa as compared to onchocerciasis-free areas.Although the causal relationship between onchocerciasis and epilepsy has yet to be proven,there is likely an association.Here we discuss the need for disease burden estimates of onchocerciasis-associated epilepsy(OAE),provide them,detail how such estimates should be refined,and discuss the socioeconomic impact of OAE,including a cost-estimate for anti-epileptic drugs.Main body:Providing OAE burden estimates may aid prevention of epilepsy in onchocerciasis-endemic areas by inciting and informing collaboration between onchocerciasis control programmes and mental health services.Epilepsy not only massively impacts the health of those affected,but it also carries a high socioeconomic burden for the households and communities involved.We used previously published geospatial estimates of onchocerciasis in Africa and a separately published logistic regression model quantifying the association between onchocerciasis and epilepsy to estimate the number of OAE cases.We then applied disability weights for epilepsy to quantify the burden in terms of years of life lived with disability(YLD)and estimate the cost of treatment.We estimate that in 2015 roughly 117000 people were affected by OAE across onchocerciasis-endemic areas previously under the African Programme for Onchocerciases control(APOC)mandate where OAE has ever been reported or suspected,and another 264000 persons in onchocerciasis-endemic areas where OAE has never been investigated before.The total number of YLDs due to OAE was 39300 and 88700 in these areas respectively,based on a weighted mean disability weight of 0.336.The burden of OAE is approximately 13%of the total YLDs attributable to onchocerciasis and 10%of total YLDs attributable to epilepsy.We estimated that by 2015 the total costs of treatment with antiepileptic drug for OAE cases would have been a minimum of 12.4 million US$.Conclusions:These estimates suggest a considerable health,social and economic burden of OAE in Africa.The treatment and care for people with epilepsy,especially in hyperendemic onchocerciasis areas with high epilepsy prevalence thus requires more financial and human resources. | Natalie V.S.Vinkeles Melchers Sarah Mollenkopf Robert Colebunders Michael Edlinger Luc E.Coffeng Julia Irani Tresor Zola Joseph N.Siewe Sake Jde Vlas Andrea S.Winkler Wilma A.Stolk | 2018 | Infectious Diseases of Poverty2018，7，1： | 3 |
| 4 | SARS传播动力学及预测模型效果初评显示文摘目的为进一步探索SARS的传播和流行规律及其与预防控制措施的关系;方法利用数学和传播动力学的方法,建立流行病学数学模型。将人群分为6类,即易感人群、暴露人群、疑似人群、确诊人群、恢复人群与死亡人群。应用天津市的流行资料调整各参数方程并进行拟合和模拟。结果基于确定性微分方程,对重要的流行参数给出了估计方法,评估疾病流行过程中的干预措施的有效性。结论模拟天津市SARS的流行情况,并对预防控制措施的执行情况进行评价。提示在保持相应控制措施的情况下,SARS的流行是可以防止和控制的。 | 韩晓娜 李承毅 方立群 冯丹 赵文娟 杨红 Sake J de Vlas 曹务春 | 2006 | 中国人兽共患病学报2006，22，6： | 2 |
| 5 | Two-step preparation for catalyst-free biodiesel fuel production显示文摘 | Sake S Kusidiana D | 2004 | Appl Biochem Biotechnol2004，，115： | 1 |
| 6 | Evidence of an association between the survival of embryos and the preiovulatory plasma progesterone concentration in the ewe显示文摘 | Ashworth C J Sakes D I Wilmut I | 1989 | J Reprod Fertil1989，87，： | 1 |
| 7 | Quantification of clinical morbidity associated with schistosome infection in sub-Saharan Africa显示文摘 | Marieke J van der Werf Sake J de Vlas Simon Brooker Caspar W.N Looman Nico J.D Nagelkerke J.Dik F Habbema Dirk Engels | 2003 | Acta Tropica2003，，2： | 1 |
| 8 | The impact of uterine fibroid embolization on resumption of menses and ovarian function显示文摘 | Chrisman HB Sake MB Ryu RK | 2000 | JVIR2000，11，6： | 1 |
| 9 | Predictive value of Plasma and cerebrospinal fluid tumour necrosis factor and interleukin - 1 concentration on outcome of fullterm infants with hypoxic - ischaemic encephalopathy显示文摘 | Nihal Oygur a Ozlem Sonnez a Osman Sake | 2009 | Arch Dis Child Fetal Neonatal ED2009，79，： | 1 |
| 10 | 女性性工作者艾滋病相关干预服务利用及影响因素研究显示文摘目的探索女性性工作者艾滋病相关干预措施利用及影响因素。方法采用方便抽样,调查深圳市1 656名女性性工作者艾滋病相关干预服务利用情况。对不进行艾滋病检测、不使用安全套以及不参与同伴教育的影响因素进行分析。同时评价未参加艾滋病检测、安全套使用与艾滋病相关知识水平之间的关系。结果女性性工作者的艾滋病检测率、安全套使用率和接受同伴教育率分别为21.5%、47.8%和28.0%。低年龄组和工作年限短与不利用3项干预服务有关。持续使用安全套和较高的艾滋病相关知识水平可提高艾滋病相关干预服务的利用率。结论深圳市女性性工作者艾滋病相关干预服务的利用率较低。鉴于安全套使用与艾滋病相关知识水平与干预措施的利用相关,应针对年轻和刚从事性服务工作者,提高其安全套使用率和艾滋病相关知识水平。 | 谭京广 蔡蕊 陈琳 Jan Hendrik Richardus Sake J.de Vlas | 2016 | 中国社会医学杂志2016，33，3： | 1 |
| 11 | Glucagon-like peptide-l infusion improves left ventricular ejection fraction and functional status in patients with chronic heart failure显示文摘 | Sakes G Nikalaidis L A Mankad S | 2006 | J Cardiac Fail2006，12，9： | 1 |
| 12 | Formation of Interface Traps in MOSFETs During Annealing Following Low Temperature Irradiation 显示文摘 | Klein RB Griscom DL | 1988 | IEEE Trans Nucl Sci1988，35，： | 1 |
| 13 | Fabry-Perot interferometers with three mirrors显示文摘 | Sake J | | Applied Optics0，，： | 1 |
| 14 | MOCVD Growth of InAsN for Infrared Applications 显示文摘 | Hiroyuki Naoi Yoshiki Nazi Shiro Sake | 1997 | SolidState Electronics1997，41，2： | 1 |
| 15 | Biodiesel fuel from rapeseed oil as prepared in supercritical methanol显示文摘 | Sake S Kusdiana D | 2001 | Fuel2001，80，： | 1 |
| 16 | Interface trap profile near the band edges at the 4H-SiC/SiO_(2) interface显示文摘 | Sake N S Mani S S Agarwal K | | 0，，： | 1 |
| 17 | Blood - brain barrier damage in reperfusion following ischemia in the hippocampus of the Mongolian gerbil brain显示文摘 | Shinou M Uneo M Sake Moto H | 1998 | Acta Neurol Scand1998，98，1： | 1 |
| 18 | Study on supercritical fluid technology显示文摘 | | 1994 | Process Technol Proc1994，11，： | 1 |
| 19 | Input-output analysis of material flows with application to iorn steel and Zinc 显示文摘 | Paul Konijin Sake de Boer Jan van Dalen | 1997 | Structural Change and Economic Dynam- ics1997，8，1： | 1 |
| 20 | Analysis of Alexandrium(Dinophyceae)species using sequences of the 18S ribosomal DNA andinternal transcribed spacer regions显示文摘 | Masao Adachi Yoshihiko Sake Yuzaburo Ishida | 1996 | Journal of Phycology1996，32，3： | 1 |
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