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| 1 | OGG1 inhibition suppresses African swine fever virus replication显示文摘African swine fever virus(ASFV)is an important pathogen that causes a highly contagious and lethal disease in swine,for which neither a vaccine nor treatment is available.The DNA repair enzyme 8-oxoguanine DNA glycosylase 1(OGG1),which excises the oxidative base lesion 8-oxo-7,8-dihydroguanine(8-oxoG),has been linked to the pathogenesis of different diseases associated with viral infections.However,the role of OGG1-base excision repair(BER)in ASFV infection has been poorly investigated.Our study aimed to characterize the alteration of host reactive oxygen species(ROS)and OGG1 and to analyse the role of OGG1 in ASFV infection.We found that ASFV infection induced high levels and dynamic changes in ROS and 8-oxoG and consistently increased the expression of OGG1.Viral yield,transcription level,and protein synthesis were reduced in ASFV-infected primary alveolar macrophages(PAMs)treated by TH5487 or SU0268 inhibiting OGG1.The expression of BER pathway associated proteins of ASFV was also suppressed in OGG1-inhibited PAMs.Furthermore,OGG1 was found to negatively regulate interferonβ(IFN-β)production during ASFV infection and IFN-βcould be activated by OGG1 inhibition with TH5487 and SU0268,which blocked OGG1 binding to 8-oxoG.Additionally,the interaction of OGG1 with viral MGF360-14-L protein could disturb IFN-βproduction to further affect ASFV replication.These results suggest that OGG1 plays the crucial role in successful viral infection and OGG1 inhibitors SU0268 or TH5487 could be used as antiviral agents for ASFV infection. | Jie Fan Xinqian Lv Saixia Yang Shuxian Geng Jifei Yang Yaru Zhao Zhonghui Zhang Zhijie Liu Guiquan Guan Jianxun Luo Qiaoying Zeng Hong Yin Qingli Niu | 2023 | Virologica Sinica2023，38，1： | 1 |
| 2 | Houttuynia cordata inhibits lipopolysaccharide-induced rapid pulmonary fibrosis by up-regulating IFN-γ and inhibiting the TGF-β1/Smad pathway显示文摘 | Shaohui Du Hui Li Yinghai Cui Lina Yang Jingjing Wu Haiyuan Huang Yangyan Chen Wei Huang Rong Zhang Jun Yang Dongfeng Chen Yiwei Li Saixia Zhang Jianhong Zhou Zhijun Wei Ngai Tan Chow | 2012 | International Immunopharmacology2012，，3： | 1 |
| 3 | Disturbance of plateau zokor-made mound stimulates plant community regeneration in the Qinghai-Tibetan Plateau, China显示文摘Mounds constructed by plateau zokors,which is widely distributed in alpine meadows significantly modified plant community structure.However,the variations of plant community structure under the disturbance of plateau zokor-made mound are less concerned.Therefore,we investigated the responses of plant community on zokor-made mound of different years(1 a and 3-4 a),and compared with undisturbed sites(no mound)in an alpine meadow in the eastern Qinghai-Tibetan Plateau(QTP),China.Species richness,coverage and Simpson diversity index were all significantly reduced by the presence of zokor-made mound,but plant heights were significantly increased,particularly in grasses and sedges.Several perennial forage species showed an increased importance value and niche breadth,including Koeleria macrantha,Elymus nutans and Poa pratensis.The effect of zokor-made mound on niche overlap showed that more intense interspecific competition produced a greater utilization of environmental resources.And this interspecific niche overlap was strengthened as succession progressed.The bare mound created by zokor burrowing activities provided a colonizing opportunity for non-dominant forage species,resulting in abundant plant species and plant diversity during the succession period.We concluded that presence of zokor-made mound was conducive to regeneration and vitality of plant community in alpine meadows,thus improving their resilience to anthropogenic stress. | XIANG Zeyu Arvind BHATT TANG Zhongbin PENG Yansong WU Weifeng ZHANG Jiaxin WANG Jingxuan David GALLACHER ZHOU Saixia | 2021 | Journal of Arid Land2021，13，10： | 0 |
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