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| 1 | Occult hepatitis B virus infection among Egyptian blood donors显示文摘AIM:To identify blood donors with occult hepatitis B virus(HBV) infection(OBI) to promote safe blood donation.METHODS:Descriptive cross sectional study was conducted on 3167 blood donors negative for hepatitis B surface antigen(HBsAg),hepatitis C antibody(HCV Ab) and human immunodeficiency virus Ab.They were subjected to the detection of alanine aminotransferase(ALT) and aspartate transaminase(AST) and screening for anti-HBV core antibodies(total) by two different techniques;[Monoliza antibodies to hepatitis B core(Anti-HBc) Plus-Bio-Rad] and(ARC-HBc total-ABBOT).Positive samples were subjected to quantitative detection of antibodies to hepatitis B surface(anti-HBs)(ETI-AB-AUK-3,Dia Sorin-Italy).Serum anti-HBs titers > 10 IU/L was considered positive.Quantitative HBV DNA by real time polymerase chain reaction(PCR)(QIAGEN-Germany) with 3.8 IU/mL detection limit was estimated for blood units with negative serum anti-HBs and also for 32 whose anti-HBs serum titers were > 1000 IU/L.Also,265 recipients were included,34 of whom were followed up for 3-6 mo.Recipients were investigated for ALT and AST,HBV serological markers:HBsAg(ETI-MAK-4,Dia Sorin-Italy),anti-HBc,quantitative detection of anti-HBs and HBV-DNA.RESULTS:525/3167(16.6%) of blood units were positive for total anti-HBc,64% of those were antiHBs positive.Confirmation by ARCHITECT anti-HBc assay were carried out for 498/525 anti-HBc positive samples,where 451(90.6%) confirmed positive.Reactivity for anti-HBc was considered confirmed only if two positive results were obtained for each sample,giving an overall prevalence of 451/3167(14.2%) for total anti-HBc.HBV DNA was quantified by real time PCR in 52/303(17.2%) of anti-HBc positive blood donors(viral load range:5 to 3.5 x 105 IU/mL) with a median of 200 IU/mL(mean:1.8 x 104 ± 5.1 x 104 IU/mL).AntiHBc was the only marker in 68.6% of donors.Univariate and multivariate logistic analysis for identifying risk factors associated with anti-HBc and HBV-DNA positivity among blood donors showed that age above thirty and marriage were the most significant risk factors for prediction of anti-HBc positivity with AOR 1.8(1.4-2.4) and 1.4(1.0-1.9) respectively.Other risk factors as gender,history of blood transfusion,diabetes mellitus,frequent injections,tattooing,previous surgery,hospitalization,Bilharziasis or positive family history of HBV or HCV infections were not found to be associated with positive anti-HBc antibodies.Among anti-HBc positive blood donors,age below thirty was the most significant risk factor for prediction of HBV-DNA positivity with AOR 3.8(1.8-7.9).According to HBV-DNA concentration,positive samples were divided in two groups;group one with HBV-DNA ≥ 200 IU/mL(n = 27) and group two with HBV-DNA < 200 IU/mL(n = 26).No significant difference was detected between both groups as regards mean age,gender,liver enzymes or HBV markers.Serological profiles of all followed up blood recipients showed that,all were negative for the studied HBV markers.Also,HBV DNA was not detected among studied recipients,none developed post-transfusion hepatitis(PTH) and the clinical outcome was good.CONCLUSION:OBI is prevalent among blood donors.Nucleic acid amplification/HBV anti core screening should be considered for high risk recipients to eliminate risk of unsafe blood donation. | Zeinab N Said Manal H El Sayed Iman I Salama Enas K Aboel-Magd Magda H Mahmoud Maged El Setouhy Faten Mouftah Manal B Azzab Heidi Goubran Amal Bassili Gamal E Esmat | 2013 | World Journal of Hepatology2013，5，2： | 4 |
| 2 | Upregula-tion of PD-1 expression on HIV-specific CD8 T cells leads to reversible immune dysfunction 显示文摘 | Trautmann L Janbazian L Chomont N Said EA Gimmig S Bessette B Boulassel MR Delwart E Sepulveda H Balderas RS Routy JP Haddad EK Sekaly RP | 2006 | Nat Med2006，12，10： | 1 |
| 3 | l)issociation of the 7S-nerve growth tactor complex in solution显示文摘 | Pantazis N J Murphy R A Saide J D | 1977 | Bioehemis- try1977，16，7： | 1 |
| 4 | Aberrant promoter methylation of SPARC in ovarian cancer显示文摘 | Socha MJ Said N Dai Y Kwong J Ramalingam P Trieu V | 2009 | Neo-plasia2009，11，： | 1 |
| 5 | Role of diffusion -weightedimaging with ADC mapping and in vivo 'H-MR spectroscopy in thy-ftjid nodules显示文摘 | El -Hariri M Gouhar G Said N | 2012 | Egypt J Radiol Nucl Med2012，43，： | 1 |
| 6 | The role of selective digestive decontamination for reducing infection in patients undergoing liver transplantation:a systematic review and meta-analysis显示文摘 | Safdar N Said A Lucey MR | 2004 | Liver Transpl2004，10，： | 1 |
| 7 | Normalization of the ovarian cancer microenvironment by SPARC显示文摘 | Said N Socha MJ Olearczyk JJ Elmarakby AA Imig JD MotamedK | 2007 | Mol Cancer Res2007，5，： | 1 |
| 8 | Time to line crossing for lane departure avoidance: A theoretical study and an experimental setting显示文摘 | SAID M SEBASTIEN G MARIANA N | 2006 | IEEE Transactions of Intelligent Transportation Systems2006，7，2： | 1 |
| 9 | The role of SPARC in the TRAMP model of prostatecarcinogenesis and progression显示文摘 | Said N Frierson Jr HF Chernauskas D Conaway M Motamed K Theodorescu D | 2009 | Oncogene2009，，28： | 1 |
| 10 | Clinical and molecular pathology of aggressive Schneiderian papilloma involving the temporal bone显示文摘 | Jones ME Wackym PA Said Al Naief N | 1998 | Head Neck1998，20，1： | 1 |
| 11 | Is bioaugmentation a feasible strategy for pollutant removal and site remediation?显示文摘 | Said EI Fantroussi Spiros N Agathos | 2005 | Current Opinion in Microbiology2005，8，： | 1 |
| 12 | First preinolar extraction effects on upper airway dimension in birnaxillary proclination patients显示文摘 | A1 Maaitah E E1 Said N Abu Alhaija ES | 2012 | Angle Orthod2012，82，5： | 1 |
| 13 | The relationship between human spenn apoptosis, morphology and the spenn defonnity index显示文摘 | AZIZ N SAID T PAASCH U | 2007 | Human Reproduction2007，22，5： | 1 |
| 14 | Aberrant promoter methylation of SPARC in ovarian cancer 显示文摘 | Socha M J Said N Dai Yanshan | 2009 | Neoplasia2009，11，2： | 1 |
| 15 | Comparison of sensory and consumer results with electronic nose and tongue sensors for apple juices显示文摘 | Rebecca N Bleibaum Herbert Stone Tsung Tan Said Labreche Emmanuelle Saint-Martin Sandrine Isz | 2002 | Food Quality and Preference2002，，6： | 1 |
| 16 | Aberrant promoter methylation of SPARC in ovarian cancer显示文摘 | Socha M J Said N Dai Y | 2009 | Neoplasia2009，11，2： | 1 |
| 17 | Thiamine putake by the human- derived renal epithelial (HEK-293) cells:cellular and molecular mechanisms 显示文摘 | Ashokkumar B Vaziri N D Said H M | 2006 | Am J Physiol Renal Physiol2006，291，： | 1 |
| 18 | Significance of squeal in disc brake design显示文摘 | Nossier T A Said M A R El Nahas N S | 1998 | Int J of Vehicle Design1998，19，1： | 1 |
| 19 | Strong expression of chemokine receptor CCR9 in diffuse large B-cell lym- phoma and follicular lymphoma strongly correlates with gastrointestinal involvement 显示文摘 | Wu W Doan N Said J | 2014 | Hum Pathol2014，45，7： | 1 |
| 20 | Normalization of the ovarian cancer microenvironment by SPARC 显示文摘 | Said N Socha M J Olearczyk JJ | 2007 | Mol Cancer Res2007，5，10： | 1 |
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