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| 1 | Cuticular hydrocarbon profiles differ between ant body parts:implications for communication and our understanding of CHC diffusion显示文摘Insect cuticular hydrocarbons(CHCs)serve as communication signals and protect against desiccation.They form complex blends of up to 150 different compounds.Due to differences in molecular packing,CHC classes differ in melting point.Communication is especially important in social insects like ants,which use CHCs to communicate within the colony and to recognize nestmates.Nestmate recognition models often assume a homogenous colony odor,where CHCs are collected,mixed,and redistributed in the postpharyngeal gland(PPG).Via diffusion,recognition cues should evenly spread over the body surface.Hence,CHC composition should be similar across body parts and in the PPG.To test this,we compared CHC composition among whole-body extracts,PPG,legs,thorax,and gaster,across 17 ant species from 3 genera.Quantitative CHC composition differed between body parts,with consistent patterns across species and CHC classes.Early-melting CHC classes were most abundant in the PPG.In contrast,whole body,gaster,thorax,and legs had increasing proportions of CHC classes with higher melting points.Intraindividual CHC variation was highest for rather solid,late-melting CHC classes,suggesting that CHCs differ in their diffusion rates across the body surface.Our results show that body parts strongly differ in CHC composition,either being rich in rather solid,late-melting,or rather liquid,early-melting CHCs.This implies that recognition cues are not homogenously present across the insect body.However,the unequal diffusion of different CHCs represents a biophysical mechanism that enables caste differences despite continuous CHC exchange among colony members. | Philipp P.SPRENGER Lisa J.GERBES Jacqueline SAHM Florian MENZEL | 2021 | Current Zoology2021，67，5： | 3 |
| 2 | Redox-responsive biocompatible nanocarriers based on novel heparosan polysaccharides for intracellular anticancer drug delivery显示文摘Heparosan is a natural precursor of heparin biosynthesis in mammals. It is stable in blood circulation but can be degraded in lysosomes, showing good biocompatibility and long circulation features. So heparosan can be designed as anticancer drug carriers to increase tumor selectivity and improve the therapeutic effect. A novel redox-sensitive heparosancystamine-vitamin E succinate(KSV) micelle system was constructed for intracellular delivery of doxorubicin(DOX). Simultaneously, the redox-insensitive heparosan-adipic acid dihydrazide-vitamin E succinate copolymer(KV) was synthesized as control. DOX-loaded micelles(DOX/KSV) with an average particle size of 90–120 nm had good serum stability and redox-triggered depolymerization. In vitro drug release test showed that DOX/KSV micelles presented obvious redox-triggered release behavior compared with DOX/KV. Cytotoxicity and cell uptake were investigated using MGC80-3 tumor cells and COS7 fibroblast-like cells. The cell survival rate of blank micelles was more than 90%, and the cytotoxicity of DOX/KSV in MGC80-3 cells was higher than in COS7 cells, indicating that the carrier has better biocompatibility and less toxicity side effect. The cytotoxicity of DOX/KSV against MGC80-3 cells was significantly greater than that of free DOX and DOX/KV. Furthermore, compared with DOX/KV in MGC80-3 cells, DOX/KSV micelles uptook more anticancer drugs and then released DOX faster into the cell nucleus. The micelles were endocytosed by multiple pathways, but clathrin-mediated endocytosis was the main pathway. Therefore, heparosan polysaccharide could be a potential option as anticancer carrier for enhancing efficacy and mitigating toxicity. | Lipeng Qiu Lu Ge Miaomiao Long Jing Mao Kamel SAhmed Xiaotian Shan Huijie Zhang Li Qin Guozhong Lv Jinghua Chen | 2020 | Asian Journal of Pharmaceutical Sciences2020，15，1： | 2 |
| 3 | Muhidrug- re - sistant urinary tract isolates of Escherichia Coli : prevalence and patient demoghics in the United States in, 2000 显示文摘 | Sahm DF Thornsberry C Mayfied DC | 2001 | Antimicrob Agents Chemother2001，45，5： | 1 |
| 4 | Malate synthasefrom Coryruebaaeri-umg glulamicum:sequence analysis of the gene and biochemical characterization of the enzyme显示文摘 | Reinscheid D Eilunaons B Sahm H | 1994 | Microbiology1994，140，11： | 1 |
| 5 | Quantitative determination of metabolic fluxs during coutilization of two carbon sources:comparative analysis with Corynebacterium glutamicum durin growth on acetate and glucose显示文摘 | Volker F Wendisch Albert A DE Graaf Hermann Sahm | 2000 | Journal of Biotechnology2000，，： | 1 |
| 6 | Identification of a novel arabinofuranosyltransferase(AftA) involved in cell wall arabinan biosynthesis in Mycobacterium tuberculosis 显示文摘 | Alderwick LJ Seidel M Sahm H | 2006 | J Biol Chem2006，281，23： | 1 |
| 7 | Threonine dehydratases of Corynebacterium glutamicum with altered allosteric control:their generation and biochemical and structural analysis显示文摘 | Mrckel M Eggeling L Sahm H | 1994 | Molecular Microbiology1994，13，5： | 1 |
| 8 | Cloning,sequence analysis,expression,and inactivation of the Corynebacterium glutamicum icd gene encoding isocitrate dehydrogenase and biochemical characterization of the enzyme显示文摘 | Eikmanns B J Rittmann D Sahm H | | 0，，： | 1 |
| 9 | Regulation of acetohydroxy acid synthase in Corynebacterium glutamicum duringfermentation of alpha-ketobutyrate to L-isoleucine显示文摘 | Eggeling I Cordes C Eggeling L Sahm H | | 0，，： | 1 |
| 10 | Response of the Central Metabolism in Corynebacterium glutamicum to the use of an NADH-Dependent Glutamate Dehydrogenase显示文摘 | Achim Marx Bernhard J. Eikmanns Hermann Sahm Albert A. de Graaf Lothar Eggeling | 1999 | Metabolic Engineering1999，，1： | 1 |
| 11 | Emerging plasmid-mediated quinolone resistance associated with the qnr gene in Klebsiella pneumoniae clinical isolates in the United States 显示文摘 | Wang M G Sahm D F Jacoby G A | 2004 | Antimicrob Agents Chemother2004，48，4： | 1 |
| 12 | Efficient representation of triangle meshes for simultaneous modification and rendering显示文摘 | Birthelmer H Soetebier I Sahm J | 2003 | Lecture Notes in Computer Science2003，，： | 1 |
| 13 | Flame spray synthesis of tin dioxide nanoparticles for gas sensing显示文摘 | Sahm T Madler L Curio A | 2004 | Sensor and Actuator2004，98，： | 1 |
| 14 | L-isoleucine production with Corynebacterium glutamicum:further flux increase and limitation of export显示文摘 | Morbach S Sahm H Eggeling L | 1996 | Applied and Environmental Microbiology1996，62，12： | 1 |
| 15 | Urban air quality in larger conurbations in the European Union显示文摘 | Frank A M Moussiopoulos N Sahm P | | 0，，： | 1 |
| 16 | Relationship between terococcal virulence and antimicrobial resistance 显示文摘 | Mundy LM Sahm DE Gilmorem M | 2002 | Clin Microbiol Rev2002，13，4： | 1 |
| 17 | Quantitative determina- tion of metabolic: fluxes during coutilization of two carbon sources: com- parative analysis with Corynebacterium glutamicum during growth on ac- etate and glucose显示文摘 | WENDISHCH VF GRAAT AA SAHM H | 2000 | J Biotechnol2000，120，5： | 1 |
| 18 | Assessing the impact of the new Athens airport to urban air quality with contemporary air pollution models显示文摘 | Moussiopoulos N Sahm P Karatzas K | | 0，，10： | 1 |
| 19 | Effects of avilamycin and essential oils on mRNA expression of apoptotic and inflamma- tory markersand gut microbiology of piglets显示文摘 | Krismar A Sahm J Pfaffl M W et o/ | 2008 | Czech Journal of Animal Science2008，53，9： | 1 |
| 20 | High bacterial diversity in permanently cold marine sediments显示文摘 | Ravenschlag K Sahm K Pernthaler J | 1999 | Applied and Environmental Microbiology1999，65，9： | 1 |
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