|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Viral and host causes of fatty liver in chronic hepatitis B显示文摘AIM: To investigate the viral and host causes of fatty liver in chronic hepatitis B patients and the role of fat deposits in liver damage.METHODS: A total of 164 patients (113 males and 51 females, average age 35±11.3 years, and range 10-62 years) with previously untreated chronic hepatitis B were included in the study. The patients were divided into two groups depending on the result of liver biopsy: group without steatosis (100 patients with <5% hepatosteatosis) and group with steatosis (64 patients with >5% hepatosteatosis). The groups were compared in terms of gender, body mass index (BMI), liver enzymes (ALT, AST, ALP, GGT), cholesterol, triglyceride, HBeAg, viral load, and histological findings. In the group with steatosis, the patients were subdivided depending on the degree of steatosis into mild group (45 patients with 5-24% steatosis), and severe group (19 patients with >25% steatosis). RESULTS: In the group of chronic hepatitis B with steatosis, the mean age, BMI, cholesterol, and triglyceride levels were significantly higher than those in the group without steatosis (P<0.05). Steatosis was found in 53 (46.9%) of male patients and 11 (22%) of female patients (P<0.05). No significant difference was found in the positivity of ALT, AST, ALP, GGT, HBeAg, viral load, histological activity index (HAI) and stage between the two groups (P>0.05). In the group with severe steatosis, the BMI was significantly higher than that in the group with mild steatosis (P<0.05). No significant difference was found in the other parameters between the groups (P>0.05). CONCLUSION: Steatosis in chronic hepatitis B appears to be a result of metabolic factors of the host rather than the effect of viruses. Steatosis is unrelated to the HAI and degree of fibrosis, which are considered as the histological indicators of liver damage. | Emin Altiparmak Seyfettin K(o|¨)klü Mesut Yalinkilic Osman Yüksel Bahattin Cicek Ertugrul Kayacetin Tülin Sahin | 2005 | World Journal of Gastroenterology2005，11，20： | 52 |
| 2 | Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors显示文摘组合指向的治疗在由堵住治疗癌症是更有效的绕过机制或导致的合成致命性。然而,他们的临床的申请被抵抗和毒性妨碍。遇见这重要挑战,我们用 ErbB2-overexpressing/PTEN-low 开发了并且测试各种各样的指向的治疗的指导 biomarker 的顺序的应用程序的一个新奇概念,高度好攻击的乳癌作为我们的模型。惊人地,从遗传上设计的鼠标与 intratumoral 异质从病人和乳房的肿瘤在两 PTEN-low/trastuzumab-resistant 乳癌支撑了 ErbB2 和下游的小径驱动器 trastuzumab 抵抗的激活。尽管 lapatinib 开始禁止了 trastuzumab 抵抗的鼠标肿瘤,肿瘤由激活表明由量的蛋白质数组出现的网络的 PI3K/mTOR 绕过抑制。有趣地,小径也是的 mTOR 的激活在 neoadjuvant 观察了表明 lapatinib 抵抗的对待 lapatinib 的病人。Trastuzumab + lapatinib 抵抗被一个 PI3K/mTOR 双 kinase 禁止者(BEZ235 ) 的顺序的申请有效地没有重要毒性克服。然而,我们的 p-RTK 数组分析证明 BEZ235 治疗在遗传上设计的老鼠肿瘤导致了增加的 ErbB2 表示和 phosphorylation,导致 BEZ235 抵抗并且在 3-D,然而并非 2-D,文化。机械学地,我们作为 BEZ235 抵抗的新奇机制识别了 ErbB2 蛋白质稳定和激活,它被随后的治疗与 lapatinib + BEZ235 联合颠倒。显著地, biomarker 指导的指向的治疗的这个顺序的应用程序在很快发展加倍的抵抗的肿瘤改变忍受极其好攻击的肿瘤的鼠标的寿命。使用的这条根本上新奇的途径有效地在一个顺序的顺序罐头指向了治疗目标和改编在在治疗期间发展抵抗的癌症的发信号的网络。 | Ozgur Sahin Qingfei Wang Samuel W Brady Kenneth Ellis Hai Wang Chia-Chi Chang Qingling Zhang Preety Priya Rui Zhu Stephen T Wong Melissa D Landis William J Muller Francisco J Esteva Jenny Chang Dihua Yu | 2014 | Cell Research2014，24，5： | 2 |
| 3 | Electrophysiological assessment of the brain function in term SGA infants显示文摘 | Ozdemir OM Ergin H Sahiner T | 2009 | Brain Res2009，1270，13： | 1 |
| 4 | Smart grid technologies: communication technologies and standards显示文摘 | Giingtir V C Sahin D Kocak T | 2011 | IEEE Transactions on Industrial Informatics2011，7，4： | 1 |
| 5 | Effects of citicoline used alone and in combination with mild hypothermia on apoptosis induced by focal cerebral ischemia in rats显示文摘 | Sahin S Alkan T Temel SG | 2010 | J Clin Neurosci2010，17，2： | 1 |
| 6 | Auto-catalyzed acetic acid pulping of jute显示文摘 | Sahin H T Young R A | 2008 | Industrial Crops and Products2008，28，1： | 1 |
| 7 | The effects of de- xmedetomidine on liver ischemia-reperfusion injury in rats 显示文摘 | SAHIN T BEGEC Z TOPRAK HI | 2013 | Journal of Surgical Research2013，183，1： | 1 |
| 8 | Do not mask the mask : use it as a premedicant 显示文摘 | Aydin T Sahin L Algin C | 2008 | Paediatr Anaesth2008，18，2： | 1 |
| 9 | Evaluation of the relationship between L5~S1spondylolysis and isthmic spondylolisthesis and lumbosacral-pelvic morphology by imaging via 2-and 3-dimensional reformatted computed tomography显示文摘 | Ergun T Sahin MS Lakadamyali H | 2011 | J Comput Assist Tomogr2011，35，1： | 1 |
| 10 | Comparison of the effect of radio-frequency tissue ablation, CO2 laser ablation, and partial turbinectomy applications on nasal mucociliary functions显示文摘 | SAPCI T SAHIN B KARAVUS A | 2003 | Laryngoscope2003，113，： | 1 |
| 11 | Comparison of the effects of radiofrequency tissue ablation, CO2 laser ablation, and partial turbinectomy applications on nasal mucociliary functions显示文摘 | SAPCI T SAHIN B KARAVUS A | 2003 | Laryngoscope2003，113，3： | 1 |
| 12 | A survey on smart grid potential applications and communication requirements显示文摘 | Gungor V C Sahin D Kocak T | 2013 | IEEE Transactions on Industrial Informatics2013，9，1： | 1 |
| 13 | Effects of internal irreversibility and heat leakage on the finite time thermoeconomic performance of refrigerators and heat pumps显示文摘 | Kodal A Sahin B Yilmaz T | 2000 | Energy Conversion and Management2000，4，6： | 1 |
| 14 | A highly immunogenic and protective middle east respiratory syndrome coro- navirus vaccine based on a recombinant measles virus vaccine platform显示文摘 | Malczyk A H Kupke A Prufer S Scheuplein V A Hutzler S Kreuz D Beissert T Bauer S Hubich Rau S Tondera C Eldin H S Schmidt J Vergara-Alert J Suzer Y Seifried J Hanschmann K M Kalinke U Herold S Sahin U Cichutek K Waibler Z Eickmann M Becker S Muhlebach M D | 2015 | J Virol2015，89，11： | 1 |
| 15 | The frequency of aspirin resistance and its risk factors in patients with metabolic syndrome显示文摘 | Kahraman G Sahin T Kilic T | 2007 | Int J Cardiol2007，115，3： | 1 |
| 16 | Comparison of some existing parametric models for magnetorheological fluid dampers 显示文摘 | SAHIN I ENGIN T CESMECI S | 2010 | Smart Material and Structure2010，，19： | 1 |
| 17 | Smart grid technologies: communication technologies and standards 显示文摘 | Giing6r V C Sahin D Kocak T | 2011 | IEEE Transactions on Industrial Informatics2011，7，4： | 1 |
| 18 | Effect of 25-hydroxycholecalciferol and soy isoflavones supplementation on bone mineralisation of quail 显示文摘 | Sahin N Balci T A Kucuk O | 2009 | British Poultry Science2009，50，6： | 1 |
| 19 | A testicular antigen aberrantly expressed in human cancers detected by autologous antibody screening显示文摘 | ChenY T Scanlan M J Sahin U | 1997 | PNAS1997，94，5： | 1 |
| 20 | Technetium-99m tetrofosmin uptake in malignant lung tumors显示文摘 | BASOGLU T SAHIN M KOPARAN A | 1995 | Eur J Nucl Med1995，22，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员