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| 1 | Diffusion-weighted magnetic resonance imaging and micro-RNA in the diagnosis of hepatic fibrosis in chronic hepatitis C virus显示文摘BACKGROUND Diffusion-weighted magnetic resonance imaging has shown promise in the detection and quantification of hepatic fibrosis. In addition, the liver has numerous endogenous micro-RNAs(miRs) that play important roles in the regulation of biological processes such as cell proliferation and hepatic fibrosis.AIM To assess diffusion-weighted magnetic resonance imaging and miRs in diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C.METHODS This prospective study included 208 patients and 82 age-and sex-matched controls who underwent diffusion-weighted magnetic resonance imaging of the abdomen, miR profiling, and liver biopsy. Pathological scoring was classified according to the METAVIR scoring system. The apparent diffusion coefficient (ADC) and miR were calculated and correlated with pathological scoring.RESULTS The ADC value decreased significantly with the progression of fibrosis, from controls(F0) to patients with early fibrosis(F1 and F2) to those with late fibrosis(F3 and F4)(median 1.92, 1.53, and 1.25 × 10^(-3) mm^2/s, respectively)(P = 0.001).The cut-off ADC value used to differentiate patients from controls was 1.83 × 10^(-3) mm^2/s with an area under the curve(AUC) of 0.992. Combining ADC and miR-200 b revealed the highest AUC(0.995) for differentiating patients from controls with an accuracy of 96.9%. The cut-off ADC used to differentiate early fibrosis from late fibrosis was 1.54 × 10^(-3) mm^2/s with an AUC of 0.866. The combination of ADC and miR-200 b revealed the best AUC(0.925) for differentiating early fibrosis from late fibrosis with an accuracy of 80.2%. The ADC correlated with miR-200 b(r =-0.61, P = 0.001), miR-21(r =-0.62, P = 0.001), and miR-29(r = 0.52,P = 0.001).CONCLUSION Combining ADC and miRs offers an alternative surrogate non-invasive diagnostic tool for diagnosing and staging hepatic fibrosis in patients with chronic hepatitis C. | Tarek Besheer Hatem Elalfy Mohamed Abd El-Maksoud Ahmed Abd El-Razek Saher Taman Khaled Zalata Wagdy Elkashef Hossam Zaghloul Heba Elshahawy Doaa Raafat Wafaa Elemshaty Eman Elsayed Abdel-Hady El-Gilany Mahmoud El-Bendary | 2019 | World Journal of Gastroenterology2019，25，11： | 9 |
| 2 | Acaricidal activities of some essential oils and their monoterpenoidal constituents against house dust mite,Dermatophagoides pteronyssinus (Acari:Pyroglyphidae)显示文摘The acaricidal activities of fourteen essential oils and fourteen of their major monoterpenoids were tested against house dust mites Dermatophagoides pteronyssinus. Five concentrations were used over two different time intervals 24 and 48 h under laboratory conditions. In general, it was noticed that the acaricidal effect based on LC50 of either essential oils or monoterpenoids against the mite was time dependant. The LC50 values were decreased by increasing of exposure time. Clove, matrecary, chenopodium, rosemary, eucalyptus and caraway oils were shown to have high activity. As for the monoterpenoids, cinnamaldehyde and chlorothymol were found to be the most effective followed by citronellol. This study suggests the use of the essential oils and their major constituents as ecofriendly biodegradable agents for the control of house dust mite, D. pteronyssinus. | SAAD El-Zemity HUSSIEN Rezk SAHER Farok AHMED Zaitoon | 2006 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2006，7，12： | 5 |
| 3 | Suppression of quantum well intermixing in GaAs/AlGaAs laser structures using phosporus-doped SiO2 encapsulant layer显示文摘 | Cusumano P Ooi B S Helmy Saher | 1997 | J Appl Phys1997，81，5： | 2 |
| 4 | Outcomes of Covered Kissing Stent Placement Compared with Bare Metal Stent Placement in the Treatment of Atherosclerotic Occlusive Disease at the Aortic Bifurcation显示文摘 | Saher S. Sabri Asim Choudhri Gianluigi Orgera Bulent Arslan Ulku C. Turba Nancy L. Harthun Klaus D. Hagspiel Alan H. Matsumoto John F. Angle | 2010 | Journal of Vascular and Interventional Radiology2010，，7： | 2 |
| 5 | Epigenetic regulation of colon cancer and intestinal stem cells显示文摘 | Saher Sue Hammoud Bradley R Cairns David A Jones | 2013 | Current Opinion in Cell Biology2013，，2： | 1 |
| 6 | Prevention of hyperhydricity in micropropagated carnation shoots by bottom cooling: Implications of oxidative stress 显示文摘 | SAHER S PIQUERAS A HELLIN E | 2005 | Plant Cell Tissue and Organ Culture2005，81，2： | 1 |
| 7 | The hepatitis B virus large surface protein is a transcriptional factor 显示文摘 | Hildt E Saher G Bruss U | 1996 | Virology1996，225，1： | 1 |
| 8 | Epigenetic regulation of colon cancer and intestinal stem cells显示文摘 | Saher Sue Hammoud Bradley R Cairns David A Jones | 2013 | Current Opinion in Cell Biology2013，，2： | 1 |
| 9 | Giant cell tumour of tendon sheath (Im'alised nodular tennsyvmvitis):clinicopathological features of 71 cases显示文摘 | Monaghan H Saher l)M AI-Nafussi A | 2001 | J Clin Pathol2001，54，5： | 1 |
| 10 | Music and Performance as Sonic Acts of Political Struggle; Counter-Political Soundscapes in Urban Realm显示文摘 | Konca Saher Murat Cetin | 2016 | Journal of Sociology Study2016，6，6： | 1 |
| 11 | The PreS-aetivator MHBs(t) of hepatitis B virus activates c-raf-1/ErK2 signaling in transgenie miee显示文摘 | Hildt E Mung B Saher G | 2002 | EMBO J2002，21，4： | 1 |
| 12 | NMDA receptor regulation by Src kinase signalling in excitatory synaptic transmission and plasticity 显示文摘 | Ali DW Saher MW | 2001 | Curr Opin Neurobio12001，11，： | 1 |
| 13 | The PreS2 activator MHBs (t) of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice显示文摘 | Hildt E Munz B Saher G | 2002 | EMBO J2002，21，： | 1 |
| 14 | Outcomes of cov- ered kissing stent placement compared with bare metal stent placement in the treatment of atherosclerotic occlu- sive disease at the aortic bifurcation显示文摘 | Saher SS Asim C Gianluigi O | 2010 | J Vase IntervRadiol2010，21，7： | 1 |
| 15 | Treatment of Renal Artery Fibromuscular Dysplasia显示文摘 | Michael A. Meuse Ulku C. Turba Saher S. Sabri Auh-Whan Park Wael E.A. Saad J. Fritz Angle Alan H. Matsumoto | 2010 | Techniques in Vascular and Interventional Radiology2010，，2： | 1 |
| 16 | The preS2 activator MHBs(t)of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice 显示文摘 | Hildt E Munz B Saher G | 2002 | EMBO J2002，21，4： | 1 |
| 17 | Prevention of hyperhydricity in micropropagated carnation shoots by bottom cooling: implications of oxidative stress 显示文摘 | SAHER S PIQUERAS A ItELLIN E | 2005 | Plant Cell Tissue and Organ Culture2005，81，2： | 1 |
| 18 | Use and evaluation of a technology-rich experimental collaborative classroom 显示文摘 | Saher | 2013 | Higher Education Research &Develop- ment2013，32，5： | 1 |
| 19 | The PreS2 activator MHBst of hepatitis B virus activates c-raf-1/Erk2 signaling in transgenic mice显示文摘 | Hildt E Munz B Saher G | 2002 | EMBO J2002，21，4： | 1 |
| 20 | The hepatitis bvirus large surface protein(LHBs)is a transcriptional activator显示文摘 | Hildt E Saher C Bruss V | 1996 | Viroloy1996，225，： | 1 |
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