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| 1 | Cytokines are early diagnostic biomarkers of graft-versus-host disease in liver recipients显示文摘BACKGROUND: Graft-versus-host disease(GVHD) is associated with high mortality. Early diagnosis is essential to start treatment and to improve outcomes. Because of the inflammatory nature, we hypothesis that cytokine profile of patients with GVHD may serve as diagnostic markers. The present study was to evaluate the role of cytokine profile in the diagnosis of GVHD.METHODS: An immunoassay was used to detect 29 cytokines simultaneously in the serum; the measuring sensitivity of all cytokines was pg/m L. Healthy subjects undergoing annual routine physical examinations served as negative controls; 23 patients with hepatocellular carcinoma(HCC) who had undergone liver transplantation(the LT group) comprised the test subjects. A total of 22 kidney recipients with biopsyconfirmed GVHD(the RT group) were included for comparison. HCC patients with radical surgery(the HCC group, n=22) served as positive control. The liver contents of the three cytokines, IL-2, IL-18, and IFN-γ, were detected with immunohistochemistry. Serum granzyme B and perforin were measured by flow cytometry.RESULTS: Of the 29 cytokines, the levels of IL-2 and IL-18 were increased significantly in liver recipients with GVHD compared with healthy controls(P<0.05). The serum levels of these three cytokines in the healthy, HCC, LT, and RT groups were IL-2: 0.90±0.02, 4.14±0.61, 5.10±0.89, and 1.48 ±0.09 pg/m L; IL-18: 80.61±9.35, 109.51±10.93, 230.11±12.92, and 61.98±7.88 pg/m L; IFN-γ: 24.06±3.88, 24.84±3.21, 40.37±5.88, and 15.33±4.72 pg/m L, respectively. Immunohistochemistry showed that these 3 cytokines expressions in the liver were parallel to the serum cytokine. After standard anti-GVHD treatment, the expressions of IL-2, IL-18, and IFN-γ were decreased in the liver(P<0.05). Serum granzyme B and perforin were significantly increased in GVHD patients(P<0.05). CONCLUSIONS: IL-2, IL-18 and IFN-γ were from liver and might serve as biomarkers for monitoring GVHD development and the effects of anti-GVHD treatment. Granzyme B and perforin may play a role in increasing IL-2, IL-18, and IFN-γ levels in GVHD patients. | Xue-Qin Meng Xin-Hua Chen Zayd Sahebally Yu-Ning Xu Sheng-Yong Yin Li-Ming Wu Shu-Sen Zheng | 2017 | Hepatobiliary & Pancreatic Diseases International2017，16，1： | 5 |
| 2 | Triple antithrombotic therapy versus double antiplatelet therapy after percutaneous coronary intervention with stent implantation in patients requiring chronic oral anticoagulation: a meta-analysis显示文摘 | Jayswal Saheb K DENG Bing-qing HU Qing-song XIE Shuang-lun GENG Deng-feng NIE Ru-qiong | 2013 | Chinese Medical Journal2013，，13： | 5 |
| 3 | Influence of Magnetic Field on the Performance of Bubble Columns and Airlift Bioreactor with Submersed Microorganisms 显示文摘 | Raja R T B M L Sonolikar R L Saheb S P | 1997 | Chemical Engineering Science1997，5，2021： | 1 |
| 4 | Prediction of laten- cy interval in preterm premature rupture of membranes using sono- graphic myometrial thickness显示文摘 | Hamdi K Bastani P Saheb - Madarek EO | 2010 | Pak J Biol Sci2010，13，： | 1 |
| 5 | Clinical outcomes for a Schlernm' s canal scaffold for lOP reduction after cataract surgery in mild to moderate open angle glaucoma submitted to AGS 显示文摘 | Ahmed IK Jampel HD Saheb H | 2012 | New York City2012，，： | 1 |
| 6 | Severe hypercholesterolaemia: therapeutic goals and eligibility criteria for LDL apheresis in Europe显示文摘 | Thompson G R Catapano A Saheb S | 2010 | Current Opinion in Lipidology2010，21，6： | 1 |
| 7 | A novel Schlernm' s canal scaffold maintains patency of collector channel ostia in human anterior segments 显示文摘 | Saheb H Johnstone MA Toris CB | 2012 | Abstract Submitted to AGS ( New York City)2012，，： | 1 |
| 8 | Microbiologi- cally influenced corrosion of archaeological arte- facts : characterisation of iron(11) sulfides by Raman spectroscopy 显示文摘 | R6mazeilles C Saheb M Neff D | 2010 | J Raman Spectrose2010，41，6： | 1 |
| 9 | Influence of magnetic field on the performance of bubble columns and airlift bioreactor with submersed microorganisms显示文摘 | Rao T B M L R Sonolikar R L Saheb S P | 1997 | Chemical Engineering Science1997，52，2122： | 1 |
| 10 | Mierobiologically influenced corrosion of archaeological artefacts: characterisation ofiron(Ⅱ) sulfides by Raman spectroseopy显示文摘 | REMAZEILLES C SAHEB M NEFF D | 2010 | J Raman Spectrosc2010，41，25： | 1 |
| 11 | A randomized controlled trial comparing polyethylene glycol+ascorbic acid with sodium picosulphate+magnesium citrate solution for bowel cleansing prior to colonoscopy显示文摘 | Sahebally SM Burke JP Chu S | 2014 | Ir J Med Sci2014，，： | 1 |
| 12 | Ultimate strength of RC wall panels in one-way in-plane action显示文摘 | Saheb SM Desayi P | 1989 | J Struct Eng ASCE1989，115，10： | 1 |
| 13 | Ultimate strength of RC wall panels in one-way in-plane action显示文摘 | Saheb SM Desayi P | 1990 | J Struct Eng ASCE1990，116，5： | 1 |
| 14 | Novel therapeutic diiminoquinone exhibits anticancer effects on human colorectal cancer cells in two-dimensional and threedimensional in vitro models显示文摘BACKGROUND Colorectal cancer(CRC) is the second leading cause of cancer-related mortality.Cancer stem cells(CSCs) in CRC, which are spared by many chemotherapeutics,have tumorigenic capacity and are believed to be the reason behind cancer relapse. So far, there have been no effective drugs to target colon CSCs. Diiminoquinone(DIQ) has shown promising effects on targeting colon cancer.However, there is limited research on the effects of DIQ on eradicating CSCs in CRC.AIM To investigate the anticancer potential of DIQ on colon CSCs in two-dimensional(2D) and three-dimensional(3D) models using colonospheres and patient-derived organoids.METHODS Various 2D methods have been used to assess the effect and the mechanism of DIQ on HCT116and HT29 cell lines including cell proliferation and viability assays, migration and invasion assays,immunofluorescence staining, and flow cytometry. The potency of DIQ was also assessed in 3D culture using the sphere formation assay and colon cancer patient-derived organoid model.RESULTS Our results showed that DIQ significantly inhibited cell proliferation, migration, and invasion in HCT116 and HT29 cell lines. DIQ treatment induced apoptosis along with an accumulation of HCT116 and HT29 cancer cells in the sub-G1 region and an increase in reactive oxygen species in both CRC cell lines. DIQ reduced sphere-forming and self-renewal ability of colon cancer HCT116and HT29 stem/progenitor cells at sub-toxic doses of 1 μmol/L. Mechanistically, DIQ targets CSCs by downregulating the main components of stem cell-related-catenin, AKT, and ERK oncogenic signaling pathways. Potently, DIQ displayed a highly significant decrease in both the count and the size of the organoids derived from colon cancer patients as compared to control and 5-fluorouracil conditions.CONCLUSION This study is the first documentation of the molecular mechanism of the novel anticancer therapeutic DIQ via targeting CSC, a promising compound that needs further investigation. | Alissar Monzer Kevork Wakimian Farah Ballout Samar Al Bitar Amani Yehya Mariam Kanso Nour Saheb Ayman Tawil Samer Doughan Maher Hussein Deborah Mukherji Walid Faraj Hala Gali-Muhtasib Wassim Abou-Kheir | 2022 | World Journal of Gastroenterology2022，28，33： | 1 |
| 15 | Corrigendum to “Sedentary lifestyle among adults in Jordan, 2007” [Family Medicine and Community Health 2016;4(3):4-8]显示文摘There were errors in Tables 7 and 8 and incorrect corresponding citations in the text.These two tables were duplications of Tables 5 and 6 respectively;they should have been removed.We regret these errors and any problems they may have caused.The citations of Tables 5 and 6 are reprinted here.Sedentary lifestyle did not apparently differ by categorized BMI(Table 5).Similarly,multilogistic regression revealed statistically significant results for housewives,students,retired people,and unemployed people(Table 6). | Ghazi F.Sharkas Tayseer Saheb Kamal Arqoub Raja Haddadin | 2016 | Family Medicine and Community Health2016，4，4： | 1 |
| 16 | Delusions and processing of discrepant information:an event-related brain potential study显示文摘 | Debruille JB Kumar N Saheb D | | 0，，： | 1 |
| 17 | Emergence of fluoroquinolones as the predominant risk factor for Clostridium difficile-associated diarrhea:a cohort study during an epidemic in Quebec显示文摘 | Pepin J Saheb N Coulombe M A | 2005 | Clin Infect Dis2005，41，8： | 1 |
| 18 | Wear and friction behavior of Al6061 alloy reinforced with carbon nanotubes 显示文摘 | Al-Qutub A M Khalil A Saheb N | 2013 | Wear2013，297，12： | 1 |
| 19 | Natural fiber polymer composites: A Review显示文摘 | Nabi Saheb D Jog J P | 1999 | Advances in Polymer Technology1999，18，4： | 1 |
| 20 | Chaos control in a discrete-time predator-prey model with weak Allee effect显示文摘The stability of the predator-prey model subject to the Allee effect is an interesting topic in recent times.In this paper,we investigate the impact of weak Allee effect on the stability of a discrete-time predator-prey model with Holling type-IV functional response.The mathematical features of the proposed model are analyzed with the help of equilibrium analysis,stability analysis,and bifurcation theory.We provide sufficient conditions for the flip bifurcation by considering Allee parameter as the bifurcation parameter.We observe that the model becomes stable from chaotic dynamics as the Allee parameter increases.Further,we observe bi-stability behavior of the model between only prey existence equilibrium and the coexistence equilibrium.Our analytical findings are illustrated through numerical simulations. | Saheb Pal Sourav Kumar Sasmal Nikhil Pal | 2018 | International Journal of Biomathematics2018，11，7： | 1 |
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