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| 1 | Cytotoxicity evaluation and hepatoprotective potential of bioassay guided fractions from Feronia limmonia Linn leaf显示文摘Objective:To evaluate the cytotoxicity and hepatoprotective potentials of extracts,fractions or isolated compound from the leaves of Feronia limonia(F.limonia).Methods:Qualitative phytochemical analysis of extracts,fractions or compound was performed by means of thin layer chromatography and spectroscopic assays.The%purity of compound was measured by analytical HPLC.Extracts,fractions or compound have been individually evaluated for their cytotoxicity effects(10,20,100,250,500,750 and 1 000 μg/mL).Based on the inhibitory concentration(IC_(50)) obtained from the cell viability assay,graded concentrations of extracts,fractions or isolated compound were assessed(10,20,50,100,200 μg/mL) for its hepatoprotective potential against CCl_4-induced hepatotoxicity by monitoring activity levels of serum glutamatic pyruvatic transaminase(SGPT) and serum glutamic oxaloacetic transaminase(SGOT).Results:Results indicated that the methanol extract of F.limonia was non-toxic and hepatoprotective in nature as compared with the petroleum ether extract.The acetone fraction of methanolic extract also showed similar properties but the subsequent two fractions were cytotoxic.However,the pure compound isolated from the penultimate fraction of methanolic extract was non-toxic and hepatoprotective in nature.Biochemical investigations(SCOT,SCPT) further corroborated these cytological observations.Conclusions:It can be concluded from this study that F.limonia methanol extract,some fractions and pure isolated compound herein exhibit hepatoprotective activity.However,cytotoxicity recorded in the penultimate fraction and investigation of structural details of pure compound warrants further study. | Mahendra Jain Rakhee Kapadia Ravirajsinh N Jadeja Menaka C Thounaojam Ranjitsinh V Devkar SH Mishra | 2011 | Asian Pacific Journal of Tropical Biomedicine2011，1，6： | 11 |
| 2 | 肠道菌群促进血管紧张素Ⅱ诱导的高血压和血管功能障碍显示文摘肠道微生物对宿主生理反应及对免疫功能的发展来说必不可少。肠道菌群对血压和全身血管功能等这些由免疫细胞功能决定的生理过程的影响知之甚少。方法:与常规饲养的小鼠(conventionally raised rats,CONV-R)比较,未受任何细菌影响的无菌小鼠(GF)表现出较为严重的全身性辅助性T细胞1型滞后。 | 刘莉 叶鹏 Karbach SH Schnfelder T Brandao I Wilms E Hrmann N Jckel S Schüler R Finger S Knorr M Lagrange J Brandt M Waisman A Kossmann S Schüfer K Münzel T Reinhardt C Wenzel P | 2016 | 中华高血压杂志2016，24，10： | 5 |
| 3 | Risk factors for acquisition of imipenem-resistant Acinetobacter baumannii: a case-control study显示文摘 | Lee SO Kim N J Choi SH | 2004 | Antimicrob Agents Chemother2004，48，1： | 1 |
| 4 | Increased IL-1 beta, IL-8 and IL-17 mRNA expression in blood mononuclear cells observed in a prospective ischemic stroke study显示文摘 | Kostulas N Pelidon SH Kivisakk P Kostulas V Link H | 1999 | Stroke1999，30，10： | 1 |
| 5 | Combined effect of SLS and (SBE) (7M)-β-CD on the solubilization of NSC-639829显示文摘 | Yang G Jain N Yalkowsky SH | 2004 | Int J Pharm2004，269，： | 1 |
| 6 | World Trade Center fine particulate matter causes respiratory tract hyperresponsiveness in mice 显示文摘 | Gavett SH HaykaI-Coates N Highfill JW | 2003 | Environ Health Perspect2003，111，7： | 1 |
| 7 | A2B adenosine receptor promotes mesenchymal stem cell differentiation to osteoblasts and bone formation in vivo 显示文摘 | Carroll SH Wigner NA Kulkarni N | 2012 | J Biol Chem2012，287，15： | 1 |
| 8 | Incremental value ofT2-we i gh t ed and d i f f us i on-weighted MRI for predictionof biochemical recurrenceafter radical prostatectomy inclinically localized prostatecancer 显示文摘 | N i sh ida K Yuen S Kamo i K et a 1 | 2011 | Acta Radiol2011，52，2： | 1 |
| 9 | The feasibility of creating a checklist for the assessment of the methodological quality both of randomised and non-randomised studies of health care interventions显示文摘 | Downs SH Black N | | 0，，： | 1 |
| 10 | Modulation of hepatitis B 6rns secretion by naturally occurring mutations in the S gene显示文摘 | Khan N Guarnieri M Ahn SH | 2004 | J ~irol2004，78，： | 1 |
| 11 | The dynamics of wave packets of highly-excited atoms and molecules显示文摘 | AVERBUKH I Sh PERELMAN N F | 1991 | Soviet Physics Uspekhi1991，，57： | 1 |
| 12 | The continuing saga of MRSA 显示文摘 | Flynn N Cohen SH | 2008 | J Infect Dis2008，197，： | 1 |
| 13 | Transformation of sporozoites into early exoerythrocytic malaria parasites does not require host cells显示文摘 | Kaiser K Camargo N Kappe SH | 2003 | J Exp Med2003，197，8： | 1 |
| 14 | Membrane resonance and subthreshold membrane oscillations in mesencephalic V neurons:participants in burst generation 显示文摘 | Wu N Hsiao CF Chandler SH | 2001 | J Neurosci2001，21，： | 1 |
| 15 | Caleincurin impo ses T cell unresponsiveness through targeted proteolysis of signaling proteins显示文摘 | Heissmeyer V Macia'n F Im SH | 2004 | Nat Immunol2004，5，： | 1 |
| 16 | Efficient generation of midbrain and hindbrain neurons from mouse embryonic stem cells显示文摘 | Lee SH Lumelsky N Studer L | 2000 | Nature Biotechnology2000，18，5： | 1 |
| 17 | Genomic screening of fibroblast growth-factor receptor 2 reveals a wide spectrum of mutations in patients with syndromic craniosyaostosis显示文摘 | Karl SH Elanko N Johnson D | 2002 | Am J Hum Genet2002，70，2： | 1 |
| 18 | Mutational analysis of WTX Gene in Wnt-catenin pathway in gastric, rolorectal, and hepalcelhdar carcinomas显示文摘 | Yoo N J Kim S Lee SH | 2009 | Dig Dis Sci2009，54，5： | 1 |
| 19 | Prediction of breast tumor progression by integrity of free circulating DNA in serum显示文摘 | Umetani N Giuliano AE Hiramatsu SH | 2006 | J Clin Oneol2006，24，26： | 1 |
| 20 | Medpor implant fixation using fibrin glue in blow-out fracture surgery 显示文摘 | Kyung H Song SH Kang N | 2013 | J Craniofac Surg2013，5，： | 1 |
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