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| 1 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 2 | Thoracic paravertebral block-ade 显示文摘 | Bond6r A Szucs S Iohom G | 2010 | Med Ultrason2010，12，3： | 1 |
| 3 | Sudden death and mortality in epilepsy显示文摘 | Szucs A Lalit N Rasonyi G | 2006 | Ideggyogy Sz2006，59，： | 1 |
| 4 | Osteochondral allograft trans-plantation from a living donor显示文摘 | Hangody LR Gál T Szucs A | | 0，，08： | 1 |
| 5 | Long-lasting, distinct changes in central opioid receptor and urinary bladder functions in models of schizophrenia in rats显示文摘 | Kekesi O Tuboly G Szucs M | 2011 | Eur J Pharmaeol2011，661，13： | 1 |
| 6 | Enteric Caliciviruses in domestic pigs in Hungary 显示文摘 | Reuter G Biroand H Szucs G | 2007 | Arch Virol2007，152，3： | 1 |
| 7 | HCN Channels Contribute to the Intrinsic Activity of Cochlear Pyramidal Cells显示文摘 | PAL B POR A SZUCS G | 2003 | Cell Mol Life Sci(S1420-682X)2003，60，10： | 1 |
| 8 | Chemokines in rheumatic diseases显示文摘 | Szekanecz Z Szucs G Szanto S | 2006 | Curr Drug Targets2006，7，1： | 1 |
| 9 | Assessment of thrombotic risk factors predisposing to thromboembolic complications in pros- thetic ortbopedic surgery 显示文摘 | Szucs G hjzner E Muszbek L | 2009 | J Orthop Sci2009，14，5： | 1 |
| 10 | Tumor-associated Antigens in Systemic Sclerosis and Systemic Lupus Erythematosus: Associations with Organ Manifestations,Immunolaboratory Markers and Disease Activity Indices显示文摘 | Szekanecz E Szucs G Szekanecz Z | 2008 | J Autoimmun2008，31，4： | 1 |
| 11 | The Penicillium chrysogenum-derived antifungal poptide shows no toxic effects on mammalian cells in the intended therapeutic concentration显示文摘 | Sappanos H Szigeti G P Pal B Rnsznak Z Szucs G Rajnovolgyi E Balla J Balla G Nagy E Leitor E Pocsi I Marx F Csernoch L | 2005 | Nannyn Schmiedeberg''s Arch Pharmacol2005，371，： | 1 |
| 12 | Enteric Calieiviruses in domestic pigs in Hungary显示文摘 | REUTER G BIROAND H SZUCS G | 2007 | Arch Virol2007，152，61： | 1 |
| 13 | Late-life absence status epi-lepticus:a female disorder显示文摘 | Szucs A Bares G Jakus R | 2008 | Epileptic Disord2008，10，2： | 1 |
| 14 | Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plans显示文摘 | Lance C Jennings Arnold S Monto Paul KS Chan Thomas D Szucs Karl G Nicholson | 2008 | The Lancet Infectious Diseases2008，，10： | 1 |
| 15 | Asymmetric periflexural exanthem of childhood and viral examinations显示文摘 | Varszegi D Szucs G | 1995 | Pediatr Dermatol1995，12，： | 1 |
| 16 | Tumor- associated antigens in systemic sclerosis and lupus erythematosus: association with organ manifestation, immunolaboratory markers and disease activity indices 显示文摘 | Szekaneez E Szucs G Szekaneez Z | 2008 | J Autoimmun2008，12，： | 1 |
| 17 | Correlation of monocyte phagocytic receptor expression with serum immune complex level in systemic lupus erythematosus显示文摘 | Kavai M Suranyi P | 1994 | Scand J Immunol1994，40，5： | 1 |
| 18 | HCN Channels Contribute to the Intrinsic Activity of Cochlear Pyramidal Cells 显示文摘 | Pal B Por A Szucs G | 2003 | Cell Mot Life Sci2003，60，10： | 1 |
| 19 | Simulation and operation of urban traffic using AI 显示文摘 | Javor A Szucs G | 1998 | Mathematics and Computers in Simulation1998，46，1： | 1 |
| 20 | Building traffic simulation software and a new concept for integration of best simulators 显示文摘 | Szucs G | 2005 | Periodica Polytechnica Transpor- tation Engineering2005，33，12： | 1 |
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