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| 1 | Restoration of energy level in the early phase of acute pediatric pancreatitis显示文摘Acute pancreatitis (AP) is a serious inflammatory disease with rising incidence both in the adult and pediatric populations. It has been shown that mitochondrial injury and energy depletion are the earliest intracellular events in the early phase of AP. Moreover, it has been revealed that restoration of intracellular ATP level restores cellular functions and defends the cells from death. We have recently shown in a systematic review and meta-analysis that early enteral feeding is beneficial in adults; however, no reviews are available concerning the effect of early enteral feeding in pediatric AP. In this minireview, our aim was to systematically analyse the literature on the treatmentof acute pediatric pancreatitis. The preferred reporting items for systematic review(PRISMA-P) were followed, and the question was drafted based on participants, intervention, comparison and outcomes: P: patients under the age of twenty-one suffering from acute pancreatitis; I: early enteral nutrition (per os and nasogastric- or nasojejunal tube started within 48 h); C: nil per os therapy; O: length of hospitalization, need for treatment at an intensive care unit, development of severe AP, lung injury (including lung oedema and pleural effusion), white blood cell count and pain score on admission. Altogether, 632 articles (Pub Med: 131; EMBASE: 501) were found. After detailed screening of eligible papers, five of them met inclusion criteria. Only retrospective clinical trials were available. Due to insufficient information from the authors, it was only possible to address length of hospitalization as an outcome of the study. Our mini-meta-analysis showed that early enteral nutrition significantly(SD = 0.806, P = 0.034) decreases length of hospitalization compared with nil per os diet in acute pediatric pancreatitis. In this minireview, we clearly show that early enteral nutrition, started within 24-48 h, is beneficial in acute pediatric pancreatitis. Prospective studies and better presentation of research are crucially needed to achieve a higher level of evidence. | Dóra Mosztbacher Nelli Farkas Margit Solymár Gabriella Pár Judit Bajor ákos Szucs József Czimmer Katalin Márta Alexandra Mikó Zoltán Rumbus Péter Varjú Péter Hegyi Andrea Párniczky | 2017 | World Journal of Gastroenterology2017，23，6： | 8 |
| 2 | Increased duodenal expression of mi R-146a and-155 in pediatric Crohn's disease显示文摘AIM: To evaluate the role of micro RNA(mi R)-146 a,-155 and-122 in the duodenal mucosa of pediatric patients with Crohn's disease(CD) and the effect of transforming growth factor-β(TGF-β) on these mi Rs in duodenal epithelial and fibroblast cells.METHODS: Formalin-fixed, paraffin-embedded biopsies derived from the macroscopically inflamed(CD inflamed: n = 10) and intact(CD intact: n = 10) duodenal mucosa of pediatric CD patients and control children(C: n = 10) were examined. Expression of mi R-146 a,-155 and-122 was determined by realtime polymerase-chain reaction(PCR). The expression of the above mi Rs was investigated in recombinant human TGF-β(1 nmol/L, 24 h) or vehicle treated small intestinal epithelial cells(CCL-241) and primary duodenal fibroblast cells derived from healthy children as well.RESULTS: Expression of mi R-146 a was significantly higher in the inflamed duodenal mucosa compared to the intact duodenal mucosa of children with CD(CD inflamed: 3.21 ± 0.50 vs CD intact: 0.62 ± 0.26, p ≤ 0.01) and to the control group(CD inflamed: 3.21 ± 0.50 vs C: 1.00 ± 0.33, p ≤ 0.05). The expression of mi R-155 was significantly increased in the inflamed region of the duodenum compared to the control group(CD inflamed: 4.87 ± 1.02 vs Control: 1.00 ± 0.40, p ≤ 0.001). The expression of mi R-122 was unchanged in the inflamed or intact mucosa of CD patients compared to controls. TGF-β treatment significantly decreased the expression of mi R-155 in small intestinal epithelial cells(TGF-β: 0.7 ± 0.083 vs Control: 1 ± 0.09, p ≤ 0.05) and also the expression of mi R-146a(TGF-β: 0.67 ± 0.04 vs Control: 1 ± 0.15, p ≤ 0.01) and mi R-155(TGF-β: 0.72 ± 0.09 vs Control: 1 ± 0.06, p ≤ 0.05) in primary duodenal fibroblasts compared to corresponding vehicle treated controls. TGF-β treatment did not influence the expression of mi R-122.CONCLUSION: The elevated expression of mi R-146 a and-155 in the inflamed duodenal mucosa of CD patients suggests the role of these mi Rs in the pathomechanism of inflammatory bowel disease. Antiinflammatory TGF-β plays an important role in the regulation of the expression of these mi Rs. | Dániel Szucs Nóra Judit Béres Réka Rokonay Kriszta Boros Katalin Borka Zoltán Kiss András Arató Attila J Szabó ádám Vannay Erna Sziksz Csaba Bereczki Gábor Veres | 2016 | World Journal of Gastroenterology2016，22，26： | 2 |
| 3 | Influenza vaccination coverage rates in five European countries-a population based cross sectional analysis of two consecutive influenza seasons显示文摘 | Szucs TD Muller D | 2005 | Vaccine2005，43，9： | 1 |
| 4 | Inner Working of Aerodynamic Sweep显示文摘 | Wadia A R Szucs P N Crall D W | 1998 | Journal of Turbomachinery1998，120，： | 1 |
| 5 | Eleetroencephalography effects to semantic and non-semantic mismatch in properties of visually presented single-characters: The N2b and the N400显示文摘 | Szucs D Soltesz F Czigler I | 2007 | Neurosci Lett2007，412，1： | 1 |
| 6 | Forward swept rotor studies in multistage fans with inlet distortion显示文摘 | Wadia A R Szucs P N Crall D W | 2002 | ASME International Gas Tur- bine Institute Turbo Expo2002，5，： | 1 |
| 7 | Inner workings of aerodynamics sweep 显示文摘 | Wadia A R Szucs P N Crall D W | 1998 | ASME Journal of Turbomachinery1998，120，： | 1 |
| 8 | Prospective survey of antibiotic utilization in pediatric hospitalized patients to identify targets for improvement of prescription显示文摘 | POTOCKI M GOETTE J SZUCS T D | 2003 | Infection2003，31，6： | 1 |
| 9 | Large deletions within the frist in- tron in VRN-1 are associated with spring growth habit in barely and wheat 显示文摘 | Fu D Szucs P Yan L etal | 2005 | Molecular Genetices and Genomics2005，273，1： | 1 |
| 10 | Large deletions within the first intron in VRN-1 are associated with spring growth habit in barley and wheat 显示文摘 | FU D SZuCS P YAN L | 2005 | Mol Genet Genomics2005，273，： | 1 |
| 11 | Motor conflict in Stroop tasks: Direct evidence from single-triM electro-myography and electro-encephalography 显示文摘 | Szucs D Sohesz F White S | 2009 | Neuroimage2009，47，4： | 1 |
| 12 | Inner workings of aerodynamic sweep显示文摘 | Wadia A R Szucs P N Crall D W | 1998 | Journal of Turbomachinery1998，120，4： | 1 |
| 13 | Inner workings of aerodynamic sweep 显示文摘 | WADIA A R SZUCS P N CRALL D W | 1998 | ASME Journal of Turbomachinery1998，120，： | 1 |
| 14 | Stress-induced car-diomyopathy ( Tako-Tsubo syndrome) in Auctria显示文摘 | Weihs V Szucs D Fellner B | 2013 | EurHeart J Acute Cardiovasc Care2013，2，2： | 1 |
| 15 | Inner work- ings of aero dynamics sweep 显示文摘 | WADIA A R SZUCS P N CRALL D W | 1998 | ASME Journal of Tur- bo Machinery1998，120，4： | 1 |
| 16 | Large deletions within the first intron in VRN-1 are associated with spring growth habit in barley and wheat显示文摘 | Fu D Szucs P Yan L | 2005 | Mol Gen Genomics2005，273，1： | 1 |
| 17 | Cost-effectiveness of bivalirudin versus heparin plus glyco- protein IIb/IIIa inhibitor in the treatment of non-ST-seg- ment elevation acute coronary syndromes显示文摘 | SCHWENKGLENKS M BRAZIER J E SZUCS T D | 2011 | Value health2011，14，1： | 1 |
| 18 | Stockpiling prepandemic influenza vaccines: a new cornerstone of pandemic preparedness plans显示文摘 | Lance C Jennings Arnold S Monto Paul KS Chan Thomas D Szucs Karl G Nicholson | 2008 | The Lancet Infectious Diseases2008，，10： | 1 |
| 19 | Large deletions within the first intron in VRN-1 are associated with spring growth habit in harley and wheat 显示文摘 | Fu D Szucs P Yan L | 2005 | Molecular Genetics and Genomics2005，273，1： | 1 |
| 20 | Cost-ef- fectiveness of bivalimdin versus heparin plus glycoprotein IIb/IIIa inhibitor in the treatment of non- ST-segment ele- vation acute coronary syndromes显示文摘 | MATI'HIAS S BRAZIER J E SZUCS T D | 2011 | Value health2011，，： | 1 |
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