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| 1 | Histone modifications and alcohol-induced liver disease:Are altered nutrients the missing link?显示文摘Alcoholism is a major health problem in the United States and worldwide,and alcohol remains the single most significant cause of liver-related diseases and deaths.Alcohol is known to influence nutritional status at many levels including nutrient intake,absorption,utilization,and excretion,and can lead to many nutritional disturbances and deficiencies.Nutrients can dramatically affect gene expression and alcohol-induced nutrient imbalance may be a major contributor to pathogenic gene expression in alcohol-induced liver disease(ALD).There is growing interest regarding epigenetic changes,including histone modifications that regulate gene expression during disease pathogenesis.Notably,modifications of core histones in the nucleosome regulate chromatin structure and DNA methylation,and control gene transcription.This review highlights the role of nutrient disturbances brought about during alcohol metabolism and their impact on epigenetic histone modifications that may contribute to ALD.The review is focused on four critical metabolites,namely,acetate,S-adenosylmethionine,nicotinamide adenine dinucleotide and zinc that are particularly relevant to alcohol metabolism and ALD. | Akshata Moghe Swati Joshi-Barve Smita Ghare Leila Gobejishvili Irina Kirpich Craig J McClain Shirish Barve | 2011 | World Journal of Gastroenterology2011，17，20： | 6 |
| 2 | Inhibition of methionine adenosyltransferase II induces FasL expression, Fas-DISC formation and caspase-8-dependent apoptotic death in T leukemic cells显示文摘蛋氨酸 adenosyltransferase II (地席 II ) 是在细胞的新陈代谢的关键酶并且从 L 蛋氨酸和 ATP 催化 S-adenosylmethionine (一样) 的形成。正常休息 T 淋巴细胞举办最小的地席 II 活动,而白血病的房间显著地显示出的激活的增殖的 T 淋巴细胞和转变 T 提高了地席 II 活动。这个工作被执行在白血病的 T 房间的幸存检验地席 II 活动和一样的生合成的角色。在一样的层次的地席 II 和结果的减少的抑制提高了 FasL mRNA 和蛋白质的表示,并且导致了圆盘(导致发信号的建筑群的死亡) 有 FADD (联系船边交货的死亡域) 和 procaspase-8 招募的形成,以及 caspase-8 激活的伴随物增加和在 c 扭动的减少铺平。开始船边交货的发信号由地席 II 抑制导致了被观察经由出价劈开连接到 mitochondrial 小径并且最终在这些房间导致增加的 caspase-3 激活和 DNA 破碎。而且,堵住地席 2A mRNA 表示,它编码地席 II 的催化子单元,用一条小介入的 RNA 途径提高了 FasL 表示和房间死亡,验证在 T 白血病的房间的幸存的地席 II 活动的必要性质。 | Tanvi S Jani Leila Gobejishvili Prachi T Hote Aditya S Barve Swati Joshi-Barve Giorgi Kharebava Jill Suttles Theresa Chen Craig J McClain Shirish Barve | 2009 | Cell Research2009，19，3： | 5 |
| 3 | Current developments and future trends in audio authentication显示文摘 | SWATI G SEONGHO C KUO C C J | 2012 | IEEE Multimedia2012，19，1： | 1 |
| 4 | Muncl8c provides stimulus-selective regula- tion of GLUT4 but not fatty acid transporter trafficking in skeletal muscle显示文摘 | Swati S J Laelie A S Jan F C | 2012 | FEBS let- ters2012，586，16： | 1 |
| 5 | Degradation studies of transparent conducting oxide: a substrate for microerystalline silicon thin film solar cells显示文摘 | DAS R SWATI T J | 2005 | Sol Energy Mater Sol Cells2005，86，： | 1 |
| 6 | Simulating the cumu- lative effects of multiple forest management strategies on land- scape measures of forest sustainability显示文摘 | Gustafson E J Lytle D E Swaty R | 2007 | Landscape Ecology2007，22，： | 1 |
| 7 | Surface spreading of intergranular corrosion on stainless steels 显示文摘 | SWATI J NOAH D B HUDSON J L | 2010 | Corrosion Science2010，，52： | 1 |
| 8 | Microwave-assisted synthesis of fine particle oxides employing wet redox mixtures显示文摘 | Swati Sigamani J P | 2002 | Journal of the America ceramic society2002，85，10： | 1 |
| 9 | Resveratrol in combination with other dietary polyphenols concomitantly enhances antiproliferation and UGT1 A1 induction in Caeo-2 cells 显示文摘 | lwuchukwu Otito F Tallarida Ronald J Nagar Swati | 2011 | Life Sciences2011，88，2324： | 1 |
| 10 | Formulation,development,and evaluation of floating pulsatile drug delivery system of atenolol显示文摘 | Swati C J Monali S S Ajay L B | 2013 | PDA J Pharm Sci and Tech2013，67，3： | 1 |
| 11 | Phyto-remediation ofmunicipal sewage by using water hyacinth(Eichhornlacrassipes)显示文摘 | Namita J Rashmi P Swati A | 2009 | J Env Bio-sci2009，23，1： | 1 |
| 12 | Simulating the cumulative effects of multiple forest management strategies on landscape measures of forest sustainability显示文摘 | Gustafson E J Lytle D E Swaty R | 2007 | Landscape Ecology2007，22，： | 1 |
| 13 | Solubility enhancement of celecoxib using β-cyclodextrin inclusion complexes显示文摘 | Swati R Sanjay K J | 2004 | European Journal of Pharmaceutics and Biophaceutics2004，57，： | 1 |
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