|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | The roles of MAPKs in disease显示文摘印射响应许多 ligands 和房间刺激涉及大量的细胞的小径和功能的家族 ases transduce 信号。MAPK 的异常或不恰当的功能现在在从癌症到煽动性的疾病到肥胖和糖尿病的疾病被识别了。在许多房间类型, MAPK ERK1/2 被连接到细胞增殖。因为在地岬和 B-Raf 的变化,能激活 ERK1/2 串联,在许多人的肿瘤被发现, ERK1/2 被认为在一些癌症起一个作用。发信号的反常 ERK1/2 也在 polycystic 肾疾病被发现了,并且象 cardio-facio-cutaneous 症候群那样的严肃的发展混乱在 ERK1/2 串联的部件从变化产生。ERK1/2 在区分得好的房间是必要的并且在神经原并且在上皮的极性的维护被连接了到长期的 potentiation。另外, ERK1/2 为在胰腺的贝它房间的胰岛素基因抄写是重要的,它响应传播葡萄糖的增加生产胰岛素在有机体允许有效葡萄糖利用和存储。导致或镇压的营养素和荷尔蒙胰岛素分泌物以在贝它房间上反映能分泌的需求的一种方式激活或禁止 ERK1/2。在这和另外的规章的小径的骚乱可以导致对某些人的混乱的病原学的 ERK1/2 的贡献。 | Michael C Lawrence Arif Jivan Chunli Shao Lingling Duan Daryl Goad Elma Zaganjor Jihan Osborne Kathleen McGlynn Steve Stippec Svetlana Earnest Wei Chen Melanie H Cobb | 2008 | Cell Research2008，18，4： | 64 |
| 2 | Rickettsia influences thermotolerance in the whitefly Bemisia tabaci B biotype显示文摘whitefly, Bemisia tabaci 怀有 Portiera aleyrodidarum,一个应尽的共生细菌,以及几个第二等的共生者包括立克次休属微生物, Hamiltonella, Wolbachia, Arsenophonus, Cardinium 和 Fritschea,的功能是未知的。在以色列,立克次休属微生物在 B 的 B 和 Q 被发现。tabaci 遗传因子型,并且当所有另外的第二等的共生者位于 bacteriomes 时,立克次休属微生物能占据大多数昆虫的身体洞。我们测试了立克次休属微生物是否影响 B 的生物学。tabaci 并且发现暴露一张包含立克次休属微生物的人口到显著地增加温度增加它的忍耐加热到达了 40 慬慴? 的吃惊 ? € 汇 ' 贉?????? 牥?? | Marina Brumin Svetlana Kontsedalov Murad Ghanim | 2011 | Insect Science2011，18，1： | 35 |
| 3 | Lanthanide NIR luminescence for telecommunications, bioanalyses and solar energy conversion显示文摘Present-day advanced technologies heavily rely on the exciting magnetic and spectroscopic properties of lanthanide ions. In particular, their ability to generate well-characterized and intense near-infrared (NIR) luminescence is exploited in any modern fiber-optic telecommunication network. In this feature article, we first summarize the whereabouts underlying the design of highly luminescent NIR molecular edifices and materials. We then focus on describing the main trends in three applications related to this spectral range: telecommunications, biosciences, and solar energy conversion. In telecommunications, efforts concentrate presently on getting easily processable polymer-based waveguide amplifiers. Upconversion nanophosphors emitting in the visible after NIR excitation are now ubiquitous in many bioanalyses while their application to bio-imaging is still in its early stages; however, highly sensitive NIR-NIR systems start to be at hand for both in vitro and in vivo imaging, as well as dual probes combining magnetic resonance and optical imaging. Finally, both silicon-based and dye-sensitized solar cells benefit from the downconversion and upconversion capabilities of lanthanide ions to harvest UV and NIR solar light and to boost the overall quantum efficiency of these next-generation devices. | Jean-Claude G. Bünzli Svetlana V. Eliseeva | 2010 | Journal of Rare Earths2010，28，6： | 22 |
| 4 | Targeting of the AKT/m-TOR Pathway: Biomarkers of Resistance to Cancer Therapy——AKT/m-TOR Pathway and Resistance to Cancer Therapy显示文摘Resistance to cancer therapy continues to be a major limitation for the successful treatment of cancer. There are many published studies on therapy resistance in breast and prostate cancers; however, there are currently no data on molecular markers associated with resistance. The conflicting data were reported regarding the AKT/m-TOR signaling pathway components as markers predicting resistance. The AKT/m-TOR signaling pathway is involved in the development of many human cancers; its activation is related to cell proliferation, angiogenesis, apoptosis, as well as to therapy resistance. Molecular alterations in the AKT/m-TOR signaling pathway provide a platform to identify universal markers associated with the development of resistance to cancer therapy. | Liudmila V SPIRINA Irina V KONDAKOVA Natalia V TARASENKO Elena M SLONIMSKAYA Evgeny A USYNIN Alexey K GORBUNOV Zahar A YURMAZOV Svetlana Yu CHIGEVSKAYA | 2018 | 中国肺癌杂志2018，21，1： | 18 |
| 5 | Small RNA Profiling Reveals Phosphorus Deficiency as a Contributing Factor in Symptom Expression for Citrus Huanglongbing Disease显示文摘Huanglongbing (HLB ) 是与类 Candidatus Liberibacter 的细菌被联系的破坏柠檬疾病(Ca。L.) 。强大的诊断工具和管理策略被需要控制 HLB。小 RNA (sRNA ) 玩的主人在调整主人回答到病原体感染的一个重要角色并且为许多人的疾病被用作早诊断的标记,包括癌症。决定是否柠檬 sRNAs 调整主人回答到 HLB, sRNAs 从柠檬 sinensis 被介绍有 Ca 的 10 和 14 星期柱子 grafting。L。asiaticus (Las ) 积极或健康的织物。十新 microRNAs (miRNAs ) , 76 保存 miRNAs,和许多小介入 RNA (siRNAs ) 被发现。几 miRNAs 和 siRNAs 被 Las 感染高度导致,并且能潜在地被开发进 HLB 的早诊断标记。miR399,被磷饥饿在另外的植物种类导致,被与类似于 HLB 的症状引起柠檬 stubborna 疾病的 Las 然而并非 Spiroplasma citri 的感染明确地导致。我们与健康的树相比在 Las 积极的柠檬树上发现了磷的 35% 减小。HLB 积极的香甜的橘子树的适用的磷 oxyanion 答案减少了 HLB 症状严厉并且显著地在西南佛罗里达在 3 年的地试用期间改进了水果生产。我们的分子,生理,并且地数据建议那磷缺乏被连接到 HLB 疾病 symptomology。 | Hongwei Zhao Ruobai Sun Ute Albrecht Chellappan Padmanabhan Airong Wanga Michael D. Coffey Thomas Girke Zonghua Wang Timothy J. Close Mikeal Roose Raymond K. Yokomi Svetlana Folimonova Georgios Vidalakis Robert Rouse Kim D. Bowman Hailing Jin | 2013 | Molecular Plant2013，6，2： | 12 |
| 6 | 油气藏铼-锇同位素定年的进展与挑战显示文摘铼(Re)、锇(Os)元素具有对氧化还原的敏感性和亲有机质特性,富集于烃源岩、油砂、原油、沥青等油气藏相关地质样品中,并被用于油气藏同位素定年。该方法既可通过Re-Os等时线直接获取油气成藏过程的绝对地质年龄,又可利用Os同位素初始值开展油源对比。分析近十余年来油气藏Re-Os同位素年代学研究的进展与不足,指出为推动该定年技术的发展及其在油气勘探实践中的应用,学术界和工业界应密切合作共同探索Re-Os同位素在油气系统中的分馏机理,全面评价硫酸盐热化学还原反应(TSR)、热解事件等后期地质过程对Re-Os同位素体系的潜在影响;综合运用无机和有机地球化学方法,建立判别油气来源的有效工具,以帮助合理选择满足同源特征的Re-Os同位素定年对象。这些问题的解决将有助于尽快建立油气藏Re-Os同位素定年的实用技术方案,并为业内的终端用户提供完整的使用指南。 | 李真 王选策 刘可禹 Tessalina Svetlana 杨雪梅 马行陟 孙海涛 | 2017 | 石油学报2017，38，3： | 11 |
| 7 | Use of models in large-area forest surveys: comparing model-assisted, model-based and hybrid estimation显示文摘This paper focuses on the use of models for increasing the precision of estimators in large-area forest surveys.It is motivated by the increasing availability of remotely sensed data,which facilitates the development of models predicting the variables of interest in forest surveys.We present,review and compare three different estimation frameworks where models play a core role:model-assisted,model-based,and hybrid estimation.The first two are well known,whereas the third has only recently been introduced in forest surveys.Hybrid inference mixes designbased and model-based inference,since it relies on a probability sample of auxiliary data and a model predicting the target variable from the auxiliary data.We review studies on large-area forest surveys based on model-assisted,modelbased,and hybrid estimation,and discuss advantages and disadvantages of the approaches.We conclude that no general recommendations can be made about whether model-assisted,model-based,or hybrid estimation should be preferred.The choice depends on the objective of the survey and the possibilities to acquire appropriate field and remotely sensed data.We also conclude that modelling approaches can only be successfully applied for estimating target variables such as growing stock volume or biomass,which are adequately related to commonly available remotely sensed data,and thus purely field based surveys remain important for several important forest parameters. | Goran Stahl Svetlana Saarela Sebastian Schnell Soren Holm Johannes Breidenbach Sean P. Healey Paul L. Patterson Steen Magnussen Erik Naesset Ronald E. McRoberts Timothy G. Gregoire | 2016 | Forest Ecosystems2016，3，2： | 7 |
| 8 | A Review on the Taxonomic,Evolutionary and Phytogeographic Studies of the Lotus Plant(Nelumbonaceae:Nelumbo)显示文摘Nelumbo Adans.(Nelumbonaceae) is an important member of the early-diverging eudicots.It contains two extant species:N.nucifera Gaertn.(the Sacred lotus),distributed in Asia and Australia and N.lutea Willd.(the American lotus),occurring in North America.This paper reviews the taxonomic,evolutionary and phytogeographic studies of the genus Nelumbo,and also raises scientific questions about it in further paleobotanic research.There are about 30 fossil species of Nelumbo established since the Early Cretaceous.Based on fossil studies,the ancestors of the extant N.nucifera and N.lutea are respectively considered to be N.protospeciosa from the Eocene to Miocene of Eurasia,and N.protolutea from the Eocene of North American.However,molecular systematic studies indicate that N.nucifera and N.lutea are probably split from a common ancestor during the Late Miocene to Early Pliocene,or even the Pleistocene,rather than separate relicts from extinct species on different continents.The characters of lotus stomatal development,seedling morphology as well as its flowering,pollination and fertilization in air reveal that it evolves from the land plants.Fossil data of Nelumbo indicates that the genus first occurs in mid-latitude area of Laurasia in the Early Cretaceous,then becomes widespread in North America and Eurasia and expands into Africa and South America during the Late Cretaceous; the genus probably colonizes the Indian Subcontinent from Asia during the Early Eocene after the collision of India and the Asian plates; the genus becomes extinct in Europe,but survives in Asia and North America during the Quaternary Ice Age,and later forms the present East Asia and North Australia-North America disjunctive distribution. | LI Ya Popova SVETLANA YAO Jianxin LI Chengsen | 2014 | Acta Geologica Sinica(English Edition)2014，88，4： | 7 |
| 9 | Characterization particulate matter from several Chinese cooking dishes and implications in health effects显示文摘Cooking fume produced by oil and food at a high temperature releases large amount of fine particulate matter(PM) which have a potential hazard to human health. This chamber study investigated particle emission characteristics originated from using four types of oil(soybean oil, olive oil, peanut oil and lard) and different kinds of food materials(meat and vegetable). The corresponding emission factors(EFs) of number, mass, surface area and volume for particles were discussed. Temporal variation of size-fractionated particle concentration showed that olive oil produced the highest number PM concentration for the entire cooking process. Multiple path particle dosimetry(MPPD) model was performed to predict deposition in the human respiratory tract. Results showed that the pulmonary airway deposition fraction was the largest. It was also found that particles produced from olive oil led to the highest deposition. We strongly recommend minimizing the moisture content of ingredients before cooking and giving priority to the use of peanut oil instead of olive oil to reduce human exposure to PM. | Lina Wang Xinran Zheng Svetlana Stevanovic Xin Wu Zhiyuan Xiang Mingzhou Yu Jing Liu | 2018 | Journal of Environmental Sciences2018，30，10： | 6 |
| 10 | Pathological changes in the cellular structures of retina and choroidea in the early stages of alloxan-induced diabetes显示文摘AIM To investigate the temporal sequence of pathological changes in the cellular structures of retina and choroidea in the early stages of diabetes in laboratory animals.METHODS Experimental type 1 diabetes was modeled by three intraperitoneal injections of an alloxan solution into 30 male nonlinear rats at 16 wk of age. The 30 th and 60 th days from the final alloxan injection were chosen as the endpoints. Light and electron microscopy and morphometric and immunohistochemical studies were performed on histological slices of eyeballs from experimental animals.RESULTS Diabetic disturbances progressed to 60 d of the experiment. Thus, in the retina, a partial destruction of photoreceptors accompanied by interstitial edema was observed. The morphometric analysis revealed a reduction in the thickness of the retina. A reduction in the number of blood vessels of the choroid with disturbances of the endothelial cells and the vascular walls and a persistent reduction in the number of melanocytes were observed. The number of proliferating Ki-67 positive cells decreased, and the number of macrophages increased with diabetes development.CONCLUSION The starting point in the development of destructive changes involves early reduction in the number of melanocytes of the choroidea and alterations in the retinal pigment epithelium. | Irina Danilova Svetlana Medvedeva Svetlana Shmakova Margarita Chereshneva Alexey Sarapultsev Petr Sarapultsev | 2018 | World Journal of Diabetes2018，9，12： | 6 |
| 11 | Diffusion and catalyst efficiency in hierarchical zeolite catalysts显示文摘The preparation of hierarchical zeolites with reduced diffusion limitation and enhanced catalyst efficiency has become a vital focus in the field of zeolites and porous materials chemistry within the past decades.This review will focus on the diffusion and catalyst efficiency of hierarchical zeolites and industrial catalysts.The benefits of diffusion and catalyst efficiency at two levels of hierarchies(zeolitic component level and industrial catalyst level)from a chemical reaction engineering point of view will be analysed.At zeolitic component level,three types of mesopores based on the strategies applied toward enhancing the catalyst effectiveness factor are presented:(i)‘functional mesopores’(raising effective difllisivity);(ii)‘auxiliary mesopores’(decreasing diffusion length);and(iii)integrated mesopores1(a combination thereof).At industrial catalyst level,location and interconnectivity among the constitutive components are revealed.The hierarchical pore interconnectivity in multi-component zeolite based industrial catalysts is exemplified by fluid catalytic cracking and bi-functional hydroisomerization catalysts.The rational design of industrial zeolite catalysts at both hierarchical zeolitic component and catalyst body levels can be fully comprehended using the advanced in situ and/or operando spectroscopic,microscopic and diffraction techniques. | Peng Peng Xiong-Hou Gao Zi-Feng Yan Svetlana Mintova | 2020 | National Science Review2020，7，11： | 6 |
| 12 | Optical multiplexing techniques and their marriage for on-chip and optical fiber communication:a review显示文摘Herein,an attention-grabbing and up-to-date review related to major multiplexing techniques is presented which in-cludes wavelength division multiplexing(WDM),polarization division multiplexing(PDM),space division multiplexing(SDM),mode division multiplexing(MDM)and orbital angular momentum multiplexing(OAMM).Multiplexing is a mech-anism by which multiple signals are combined into a shared channel used to showcase the maximum capacity of the op-tical links.However,it is critical to develop hybrid multiplexing methods to allow enhanced channel numbers.In this re-view,we have also included hybrid multiplexing techniques such as WDM-PDM,WDM-MDM and PDM-MDM.It is prob-able to attain N×M channels by utilizing N wavelengths and M guided-modes by simply utilizing hybrid WDM-MDM(de)multiplexers.To the best of our knowledge,this review paper is one of its kind which has highlighted the most prom-inent and recent signs of progress in multiplexing techniques in one place. | Svetlana Nikolaevna Khonina Nikolay Lvovich Kazanskiy Muhammad Ali Butt Sergei Vladimirovich Karpeev | 2022 | Opto-Electronic Advances2022，5，8： | 6 |
| 13 | Mechanism of diarrhea in microscopic colitis显示文摘AIM: To search the pathophysiological mechanism of diarrhea based on daily stool weights, fecal electrolytes,osmotic gap and pH.METHODS: Seventy-six patients were included: 51 with microscopic colitis (MC) [40 with lymphocytic colitis (LC);11 with collagenous colitis (CC)]; 7 with MC without diarrhea and 18 as a control group (CG). They collected stool for 3 d. Sodium and potassium concentration were determined by flame photometry and chloride concentration by titration method of Schales. Fecal osmotic gap was calculated from the difference of osmolarity of fecal fluid and double sum of sodium and potassium concentration.RESULTS: Fecal fluid sodium concentration was significantly increased in LC 58.11±5.38 mmol/L (P<0.01)and CC 54.14±8.42 mmol/L (P<0.05) than in CG 34.28±2.98 mmol/L. Potassium concentration in LC 74.65±5.29 mmol/L (P<0.01) and CC 75.53±8.78 mmol/L (P<0.05) was significantly less compared to CG 92.67±2.99 mmol/L.Chloride concentration in CC 36.07±7.29 mmol/L was significantly higher than in CG 24.11±2.05 mmol/L (P<0.05).Forty-four (86.7%) patients had a secretory diarrhea compared to fecal osmotic gap. Seven (13.3%) patients had osmotic diarrhea.CONCLUSION: Diarrhea in MC mostly belongs to the secretory type. The major pathophysiological mechanism in LC could be explained by a decrease of active sodium absorption. In CC, decreased Cl/HCO3 exchange rate and increased chloride secretion are coexistent pathways. | Marijana Protic Njegica Jojic Daniela Bojic Svetlana Milutinovic Dusanka Necic Bozidar Bojic Petar Svorcan Miodrag Krstic Obren Popovic | 2005 | World Journal of Gastroenterology2005，11，35： | 5 |
| 14 | 永久冻土与变化的气候:俄罗斯的前景显示文摘永久冻土地区大约占据整个北半球陆地表面的25%,占据俄罗斯整个陆地表面的60%以上。最近几十年,在许多地方观测到了永久冻土的变暖、融化和消退现象,这些现象可能随着气候的变化在未来出现加速的趋势。永久冻土的变化对北部大陆的自然体系、人类以及经济具有重要的意义。数学模型的结果表明,到21世纪中期,北半球近表层的永久冻土将缩小15%~30%。这将导致上面几米冻土土地的完全融化,同时,其他地区季节性融化的平均深度也将增加15%~25%,最北部位置将增加50%或者更多。这些变化将改变苔原地带碳吸收和释放的平衡,以及加速温室气体从富碳的北极湿地释放出来。永久冻土的融化对建筑在其上面的基础设施结构的影响已经引起了公众的严重关注。气候原因引起的永久冻土特性的变化,对北部陆地的几乎所有建筑结构都存在着潜在的危害,并可能将其中的很多变成不可使用的建筑。永久冻土的消退和热喀斯特地形引起的地面沉降,将导致地形的戏剧性变形以及造成水文和植被的改变,并可能最终造成现有地形的变化。最近的研究表明,非气候因素,如水文和植被的改变,可能在很大程度上控制着永久冻土对气候变暖的反应。为了更好地理解和量化在日渐变化的北部环境中多种因素产生的影响,我们需要进行更多的研究。 | Oleg Anisimov Svetlana Reneva 李娜(译) | 2006 | AMBIO-人类环境杂志2006，35，4： | 5 |
| 15 | Expression of Mitochondrial Gene Fragments within the Tapetum Induce Male Sterility by Limiting the Biogenesis of the Respiratory Machinery in Transgenic Tobacco显示文摘Plant mitochondrial genomes (mtDNAs) are large and undergo frequent recombination events. A common phenotype that emerges as a consequence of altered mtDNA structure is cytoplasmic-male sterility (CMS). The molecular basis for CMS remains unclear, but it seems logical that altered respiration activities would result in reduced pollen production. Analysis of tobacco (Nicotiana tabacum) mtDNAs indicated that CMS-associated loci often contain fragments of known organellar genes. These may assemble with organellar complexes and thereby interfere with normal respiratory functions. Here, we analyzed whether the expression of truncated fragments of mitochondrial genes (i.e. atp4, cox1 and rps3) may induce male sterility by limiting the biogenesis of the respiratory machinery. cDNA fragments corresponding to atp4f, cox1f and rps3f were cloned in-frame to a mitochondrial localization signal and a C-termini HA-tag under a tapetum-specific promoter and introduced to tobacco plants by Agrobacterium-mediated transformation. The constructs were then analyzed for their effect on mitochondrial activity and pollen fertility. Atp4f , Cox1f and Rps3f plants demonstrated male sterility phenotypes, which were tightly correlated with the expression of the recombinant fragments in the floral meristem. Fractionation of native organellar extracts showed that the recombinant ATP4f-HA, COX1f-HA and RPS3f-HA proteins are found in large membrane-associated particles. Analysis of the respiratory activities and protein profiles indicated that organellar complex I was altered in Atp4f, Cox1f and Rps3f plants. | Felix Shaya Svetlana Gaiduk Ido Keren Sofia Shevtsov Hanita Zemah Eduard Belausov Dalia Evenor Moshe Reuveni Oren Ostersetzer-Biran | 2012 | Journal of Integrative Plant Biology2012，54，2： | 4 |
| 16 | Compliance and adherence to oral anticoagulation therapy in elderly patients with atrial fibrillation in the era of direct oral anticoagulants显示文摘 | Svetlana V Garkina Tatiana V Vavilova Dmitry S Lebedev Evgeny N Mikhaylov | 2016 | Journal of Geriatric Cardiology2016，13，9： | 4 |
| 17 | Modelling of microbial enhanced oil recovery application using anaerobic gas-producing bacteria显示文摘Microbial enhanced oil recovery(MEOR) methods apply injection of bacteria to depleted oil reservoirs to produce oil, which had remained unrecovered after the conventional methods of production. The ability of thermophilic anaerobic bacteria to produce gas as the main mechanism in potential MEOR in high salinities of 70-100 g/L was investigated in this study. Maximum gas production of up to 350 mL per 700 mL of salty solution was produced at a salinity of 90 g/L stably during 2-4 days of experiment. The experimental results were upscaled to the Snorre Oilfield, Norway, and simulated using ECLIPSE software for 27 months. The best scenarios showed that the increase in oil recovery on average was at 21% and 17.8% respectively. This study demonstrated that anaerobic bacteria used in biogas plants could be an attractive candidate for MEOR implementation due to their ability to withstand high temperature and salinity, and produce gas in large volumes. | Pavel Spirov Yanina Ivanova Svetlana Rudyk | 2014 | Petroleum Science2014，11，2： | 4 |
| 18 | Global trends in diabetes-related mortality with regard to lifestyle modifications,risk factors,and affordable management:A preliminary analysis显示文摘Background:According to the World Health Organization (WHO),a global reduction of 17% has been achieved in the major noncommunicable disease-associated mortality rate since 2000.This decline was due to the decreasing mortality associated with cardiovascular and chronic respiratory diseases. The WHO has not made any comments on diabetes-related mortality thus far.The objective of this study was to demonstrate trends in diabetes-related mortality associated with country-wide interventions.Methods:The WHO statistics were used to assess trends in diabetes-related mortality from 2000 to 2016.Different types of community-based interventions in 49 countries were compared and assessed.Results:The baseline mortality decreased by 7%.Mortality in middle-income countries was higher than that in high-income countries. The prevalence of obesity showed a gradual increase in all countries. After implementation of the WHO 'best buy' in 2010, mortality increased in 17 countries and decreased in 32 countries. Regarding the smoking prevalence trend, 87% countries with decreasing diabetes-related mortality had a gradual decline in tobacco usage since 2000.The decline was observed only in 43% countries with increasing diabetes-related mortality. The prevalence of hypertension increased in 19% countries with declining diabetes-related mortality and in 35% countries with increasing diabetes-related mortality. Physical activity measures tended to be better implemented in countries with declining diabetes-related mortality than in countries with increasing diabetes-related mortality.Conclusion:Smoking cessation and better blood pressure control are associated with declining diabetes-related mortality. Longer implementation periods are needed for other lifestyle interventions. | Nikolai Khaltaev Svetlana Axelrod | 2021 | Chronic Diseases and Translational Medicine2021，7，3： | 4 |
| 19 | Antiviral activity of Basidiomycete mycelia against influenza type A(serotype H1N1) and herpes simplex virus type 2 in cell culture显示文摘In this study, we investigated the in vitro antiviral activity of the mycelia of higher mushrooms against influenza virus type A(serotype H1N1) and herpes simplex virus type 2(HSV-2), strain BH. All 10 investigated mushroom species inhibited the reproduction of influenza virus strain A/FM/1/47(H1N1) in MDCK cells reducing the infectious titer by 2.0–6.0 lg ID50. Four species, Pleurotus ostreatus, Fomes fomentarius, Auriporia aurea, and Trametes versicolor, were also determined to be effective against HSV-2 strain BH in RK-13 cells, with similar levels of inhibition as for influenza. For some of the investigated mushroom species—Pleurotus eryngii, Lyophyllum shimeji, and Flammulina velutipes—this is the first report of an anti-influenza effect. This study also reports the first data on the medicinal properties of A. aurea, including anti-influenza and antiherpetic activities. T. versicolor 353 mycelium was found to have a high therapeutic index(324.67), and may be a promising material for the pharmaceutical industry as an anti-influenza and antiherpetic agent with low toxicity. Mycelia with antiviral activity were obtained in our investigation by bioconversion of agricultural wastes(amaranth flour after CO2 extraction), which would reduce the cost of the final product and solve some ecological problems. | Tetiana Krupodorova Svetlana Rybalko Victor Barshteyn | 2014 | Virologica Sinica2014，29，5： | 4 |
| 20 | Value of two-phase dynamic multidetector computed tomography in differential diagnosis of post-inflammatory strictures from esophageal cancer显示文摘AIM: To characterize the computed tomography(CT) findings in patients with post-inflammatory esophageal strictures(corrosive and peptic) and reveal the optimal scanning phase protocols for distinguishing postinflammatory esophageal stricture and esophageal cancer.METHODS: Sixty-five patients with esophageal strictures of different etiology were included in this study: 24 patients with 27 histopathologically confirmed corrosive strictures, 10 patients with 12 peptic strictures and 31 patients with esophageal cancer were evaluated with a two-phase dynamic contrast-enhanced MDCT. Arterial and venous phases at 10 and 35 s after the attenuation of 200 HU were obtained at the descending aorta, with a delayed phase at 6-8 min after the start of injection of contrast media. For qualitative analysis, CT scans of benign strictures were reviewed for the presence/absence of the following features: 'target sign', luminal mass, homogeneity of contrast medium uptake, concentric wall thickening, conically shapedsuprastenotic dilatation, smooth boundaries of stenosis and smooth mucous membrane at the transition to stenosis, which were compared with a control group of 31 patients who had esophageal cancer. The quantitative analysis included densitometric parameter acquisition using regions-of-interest measurement of the zone of stenosis and normal esophageal wall and the difference between those measurements(ΔCT) at all phases of bolus contrast enhancement. Esophageal wall thickening, length of esophageal wall thickening and size of the regional lymph nodes were also evaluated. RESULTS: The presence of a concentric esophageal wall, conically shaped suprastenotic dilatation, smooth upper and lower boundaries, 'target sign' and smooth mucous membrane at the transition to stenosis were suggestive of a benign cause, with sensitivities of 92.31%, 87.17%, 94.87%, 76.92% and 82.05%, respectively, and specificities of 70.96%, 89.66%, 80.65%, 96.77% and 93.55%, respectively. The features that were most suggestive of a malignant cause were eccentric esophageal wall thickening, tuberous upper and lower boundaries of stenosis, absence of mucous membrane visualization, rupture of the mucous membrane at the upper boundary of stenosis, cup-shaped suprastenotic dilatation, luminal mass and enlarged regional lymph nodes with specificities of 92.31% 94.87%, 67.86%, 100%, 97.44%, 94.87% and 82.86%, respectively and sensitivities of 70.97%, 80.65%, 96.77%, 80.65%, 54.84%, 87.10% and 60%, respectively. The highest tumor attenuation occurred in the arterial phase(mean attenuation 74.13 ± 17.42 HU), and the mean attenuation difference between the tumor and the normal esophageal wall(mean ΔCT) in the arterial phase was 23.86 ± 19.31 HU. Here, 11.5 HU of ΔCT in the arterial phase was the cut-off value used to differentiate esophageal cancer from post-inflammatory stricture(P = 0.000). The highest attenuation of postinflammatory strictures occurred in the delayed phase(mean attenuation 71.66 ± 14.28 HU), and the mean ΔCT in delayed phase was 34.03 ± 15.94 HU. Here, 18.5 HU of ΔCT in delayed phase was the cut-off value used to differentiate post-inflammatory stricture from esophageal cancer(P < 0.0001).CONCLUSION: The described imaging findings reveal high diagnostic significance in the differentiation of benign strictures from esophageal cancer. | Grigory G Karmazanovsky Svetlana A Buryakina Evgeny V Kondratiev Qin Yang Dmitry V Ruchkin Dmitry V Kalinin | 2015 | World Journal of Gastroenterology2015，21，29： | 3 |
您所在的机构暂未开通此部分的功能，请联系管理员