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| 1 | Pre-diagnostic levels of adiponectin and soluble vascular cell adhesion molecule-1 are associated with colorectal cancer risk显示文摘AIM: To examine the relationships between pre-diagnostic biomarkers and colorectal cancer risk and assess their relevance in predictive models.METHODS: A nested case-control study was designed to include all first primary incident colorectal cancer cases diagnosed between inclusion in the SUpplémentation en VItamines et Minéraux AntioXydants cohort in 1994 and the end of follow-up in 2007. Cases (n = 50) were matched with two randomly selected controls (n = 100). Conditional logistic regression models were used to investigate the associations between pre-diagnostic levels of hs-CRP, adiponectin, leptin, soluble vascular cell adhesion molecule-1 (sVCAM-1), soluble intercellular adhesion molecule-1, E-selectin, monocyte chemoattractant protein-1 and colorectal cancer risk. Area under the receiver operating curves (AUC) and relative integrated discrimination improvement (RIDI) statistics were used to assess the discriminatory potential of the models. RESULTS: Plasma adiponectin level was associated with decreased colorectal cancer risk (P for linear trend = 0.03). Quartiles of sVCAM-1 were associated with increased colorectal cancer risk (P for linear trend = 0.02). No association was observed with any of the other biomarkers. Compared to standard models with known risk factors, those including both adiponectin and sVCAM-1 had substantially improved performance for colorectal cancer risk prediction (P for AUC improvement = 0.01, RIDI = 26.5%). CONCLUSION: These results suggest that pre-diagnostic plasma adiponectin and sVCAM-1 levels are associated with decreased and increased colorectal cancer risk, respectively. These relationships must be confirmed in large validation studies. | Mathilde Touvier Léopold Fezeu Namanjeet Ahluwalia Chantal Julia Nathalie Charnaux Angela Sutton Caroline Méjean Paule Latino-Martel Serge Hercberg Pilar Galan Sébastien Czernichow | 2012 | World Journal of Gastroenterology2012，18，22： | 15 |
| 2 | Potentialfor reduction of odorous compounds in seine manure through diet modification 显示文摘 | A L K B Kephart M W A Verstegen | 1998 | J Anim Sci (Submitted)1998，，： | 1 |
| 3 | Serotonin 2C receptor agonistsimprove type 2 diabetes via melanocortin-4 receptor signaling pathways显示文摘 | Zhou L Sutton GM Rochford JJ | 2007 | Cell Metab2007，6，5： | 1 |
| 4 | Potential for reduction of odorous compounds in swine manure through diet modification显示文摘 | Sutton A L Kephart K B Verstegen M W A | 1999 | Journal of Animal Science1999，77，： | 1 |
| 5 | Effects of adding fiber sources to reduced-crude protein,amino acid-supplemented diets on nitrogen excretion,growth performance,and carcass traits of finishing pigs1,2显示文摘 | Shriver J A Carter S D Sutton A L | 2003 | Journal of Animal Science2003，81，： | 1 |
| 6 | Annular gas flow theory and prevention methods described显示文摘 | SUTTON D L FAUL R SABINS F | 1984 | Oil and Gas Journal1984，10，82： | 1 |
| 7 | GEM-2:A new multifrequency electro- magnetic sensor显示文摘 | Won I J Keiswetter D A Fields G RA and Sutton L C | 1996 | Journal of Environmental and Engineering Geophysics1996，1，2： | 1 |
| 8 | Comparison of Surgical Risk Score,POSSUM and p-POSSUM in higher-risk surgical pa?tients显示文摘 | Brooks l\{f Sutton R Sarin S | 2005 | Br J Surg2005，92，10： | 1 |
| 9 | Semen and carcass evaluation of broiler breeder males fed low protein diets 显示文摘 | WILSON J L MCDANIEL G R SUTTON C D | 1987 | Pouh Sci1987，66，9： | 1 |
| 10 | β-Lactogloglobulin as a Potential modu- lator of intestinal activity and morphology in neonatal piglets 显示文摘 | SUTTON L F ALSTON-MILIS B | 2006 | The Anatomical Record Part A2006，288，： | 1 |
| 11 | Fulbfield repersentation of discretely smapled surface deformational for displacement and strain analysis 显示文摘 | Sutton M A Turner J L Burck H A | 1991 | Experimental Meehnaies1991，31，2： | 1 |
| 12 | Craniometric and Velopharyngeal Assessment of Infants With and Without Cleft Palate显示文摘 | Jamie L Perry David P Kuehn T Bradley P Sutton | | 0，，： | 1 |
| 13 | Impact of Field Release of Genetically Modified Pseudomonas Fluoreseens on Indigenous Microbial Populations of Wheat显示文摘 | DE L F SUTTON E J WHIPPS J M | 1995 | Appl Environ Micrnbiol1995，61，： | 1 |
| 14 | The growth performance,carcass characteristics,and meat quality of halothane carrier and negative pigs显示文摘 | Leach L M Ellis M Sutton D S | 1996 | Journal of Animal Science1996，74，： | 1 |
| 15 | Plasma and urinary oxalate and glycolate in healthy subjects显示文摘 | Hagen L Walker VR Sutton RA | 1993 | Clin Chem1993，39，1： | 1 |
| 16 | Cyclostationary sig - natures in practical cognitive radio applications 显示文摘 | Sutton P Nolan K Doyle L | 2008 | IEEE JSAC2008，26，1： | 1 |
| 17 | An ultrasonic device for nondestructive testing of oilwell cements at elevated temperatures and pressures 显示文摘 | Rao P P Sutton D L Childs J D etal | 1982 | Journal of Petroleum Technology1982，34，11： | 1 |
| 18 | Haboobs显示文摘 | | 1925 | Quarterly Journal of the Royal Meteorological Society1925，51，： | 1 |
| 19 | Two pleiotropic classes of daf-2 mutation affect larval arrest,adult behavior,reproduction and longevity in Caenorhabditis elegans显示文摘 | GEMS D SUTTON A J SUNDERMEYER M L | 1998 | Genetics1998，150，1： | 1 |
| 20 | 成人2型糖尿病不同筛查及预防策略成本效益分析显示文摘目的 比较针对2型糖尿病预防及治疗的4种筛查策略及随后予以的干预措施:(a)筛查2型糖尿病患者使其能接受早期检查及治疗,(b)筛查2型糖尿病和糖耐量受损患者,对糖耐量受损的人群予以生活方式干预以延缓或预防糖尿病的发生,(c)同(b)但予以药物干预措施,(d)不筛查。
设计 成本效益决策分析建立在对概率的发展和评估基础上,是从筛查到死亡的综合性经济决策分析模型。
研究对象 一组假设人群,筛查时年龄45岁,高于平均糖尿病风险水平。
数据来源 电子书目数据库收录的已发表的临床试验和流行病学研究;补充数据分别来自英国和威尔士健康统计署、风险筛查(STAR)研究和ADDITION研究的Leicester部分。
方法 建立一种决策树/Markov混合模型,以模拟每一种筛查策略的长期效用,包括临床和成本效益终点。该模型假设水平跨度为50年时间,其成本效益折损率为3.5%。采用敏感度分析以验证模型假设及确定哪种模型数据输入对结果的影响最大。
结果 与不筛查策略比较,筛查2型糖尿病、筛查糖尿病和糖耐量受损并予以生活方式干预、筛查糖尿病和糖耐量受损并予以药物干预治疗3种策略,每获得一个质量调整生命年(QALY)估计所需成本分别为(每年成本效益贴现率为3.5%)14150英镑(17560欧元;27860美元)、6242英镑和7023英镑。在支付意愿阈值为20000英镑时,各主动筛查策略通过干预产生的成本效益概率分别为49%,93%和85%。
结论 对年龄45岁、高于平均风险水平的人群进行2型糖尿病和糖耐量受损的筛查,并对糖耐量受损人群予以适当的干预似乎具有很好的成本效益。单独筛查糖尿病而不对糖耐量受损人群予以干预的策略具有的成本效益仍不确定,需要进一步研究确定早期检测糖尿病的作用。 | Clare L Gillies Paul C Lambert Keith R Abrams Alex J Sutton Nicola J Cooper Ron T Hsu Melanie J Davies Kamlesh Khunti 张晓梅(译) 纪立农(校) | 2008 | 英国医学杂志中文版2008，11，5： | 1 |
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