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| 1 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 2 | A DNA vector-based RNAi technology to suppress gene expression in mammalian cells显示文摘 | Sui G Soohoo C Affar el B Gay F Shi Y Forrester W C Shi Y | | 0，，： | 2 |
| 3 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients显示文摘 | Dai Y Sui W Lan H | 2009 | Rheumatol Int2009，29，7： | 1 |
| 4 | Fusion of conven- tional ultrasound imaging and acousto-optic sensing by use of a standard pulsed-ultrasound scanner 显示文摘 | BOSSY E SUI L MURRAY T W | 2005 | Opt Lett2005，30，7： | 1 |
| 5 | Surface characteristics and electrochemical corrosion behavior of fluorinated diamond- like carbon (F-DLC) films on the NiTi alloys 显示文摘 | Sui J H Zhang Z G Cai W | 2009 | Nuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms2009，267，15： | 1 |
| 6 | Optimizing the utilization of kidneys from small pediatric deceased donors under 15 kg by choosing pediatric recipients显示文摘 | Sui M Zhao W Chen Y | 2015 | Pediatr Transplant2015，，： | 1 |
| 7 | Antitumor effect of a selective COX-2 inhibitor, celecoxib, may be attributed to angiogenesis inhibition through modulating the PTEN/PI3K/Akt/HIF-1 pathway in an H22 murine hepatocarcinoma model显示文摘 | Sui W Zhang Y Wang Z | 2014 | Oncol Rep2014，31，5： | 1 |
| 8 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 9 | Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association显示文摘 | Li W H Wayne A | 2004 | PNAS2004，101，8： | 1 |
| 10 | Effect of pulsed electric field and thermal treatment on the physicochemical and functional properties of whey protein isolate 显示文摘 | Sui Q A Roginski H Williams R P W | 2011 | International Dairy Journal2011，21，4： | 1 |
| 11 | Dielectric properties and conductivity of carbon nanofiber/semi-crystalline polymer com- posites显示文摘 | SUI G JANA S ZHONG W H | 2008 | Acta Materialia2008，56，10： | 1 |
| 12 | Antiviral effect of diammonium glycyrrhizinate and lithium chloride on cell infection by pseudorabies herpesvirus显示文摘 | Sui X W Yin J C Ren X F | 2010 | Antiviral Res2010，85，2： | 1 |
| 13 | Precursor B-cell lymphoblastic leukemia of the arm mimicking neurogenic tumor: case report 显示文摘 | Sui XF Liu WY Guo W | 2012 | World J Surg Oncol2012，10，： | 1 |
| 14 | Polyester plastination of biological tissue:hoffen P45 technique显示文摘 | SUI H HENRY R W | 2007 | J Int Soc Plastination2007，22，： | 1 |
| 15 | Redistribution of biosolids-derived total P applied to a Mollisol 显示文摘 | SUI Y THOMPSON M L MIZE C W | 1999 | Journal of Environmental Quality1999，28，： | 1 |
| 16 | Microstructttres and magnetic property in Mn-rich off-stoichiometric Mn2NiGa Heusler alloys显示文摘 | ZHANG J CAI W GAO Z Y SUI J H | 2008 | Scripta Mater2008，58，： | 1 |
| 17 | Extending the Two-Dimensional FDTD Method to Hybrid Electromagnetic Systems with Active and Passive Lumped Elements 显示文摘 | Sui W Chirstensen D A Durney C H | 1992 | IEEE Trans Microwave Theory tech1992，40，4： | 1 |
| 18 | Expression of MMP-2 and TIMP-2 in renal tissue of patients with ehronie aetive antibody-mediated renal graft rejeetion 显示文摘 | YAN Q SUI W WANG B | 2012 | Diagn Pathol2012，137，1： | 1 |
| 19 | Comprehensive analysis of microRNA expression patterns in renal biopsies of lupus nephritis patients显示文摘 | Dai Y Sui W Lan H | 2009 | Rheumatol Int2009，29，7： | 1 |
| 20 | Angiotensin-converting enzyme 2 is a functional receptor for the SALS coronavirus 显示文摘 | Li W Moore MJ Vasilieva N Sui J Wong SK Berne MA | 2003 | Nature2003，，： | 1 |
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