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| 1 | Arsenic trioxide promotes mitochondrial DNA mutation and cell apoptosis in primary APL cells and NB4 cell lines显示文摘This study aimed to investigate the effects of arsenic trioxide(As2O3) on the mitochondrial DNA(mtDNA) of acute promyelocytic leukemia(APL) cells.The NB4 cell line was treated with 2.0 μmol/L As2O3 in vitro,and the primary APL cells were treated with 2.0 μmol/L As2O3 in vitro and 0.16 mg kg-1 d-1 As2O3 in vivo.The mitochondrial DNA of all the cells above was amplified by PCR,directly sequenced and analyzed by Sequence Navigatore and Factura software.The apoptosis rates were assayed by flow cytometry.Mitochondrial DNA mutation in the D-loop region was found in NB4 and APL cells before As2O3 use,but the mutation spots were remarkably increased after As2O3 treatment,which was positively correlated to the rates of cellular apoptosis,the correlation coefficient:rNB4-As2O3=0.973818,and rAPL-As2O3=0.934703.The mutation types include transition,transversion,codon insertion or deletion,and the mutation spots in all samples were not constant and regular.It is revealed that As2O3 aggravates mtDNA mutation in the D-loop region of acute promyelocytic leukemia cells both in vitro and in vivo.Mitochondrial DNA might be one of the targets of As2O3 in APL treatment. | MENG Ran1,ZHOU Jin2,SUI Meng3,LI ZhiYong4,FENG GuoSheng1 & YANG BaoFeng2 1 Division of Neurology,the Ninth Clinical Medical College of Beijing University(Shijitan Hospital),Beijing 100038,China 2 The First Hospital of Harbin Medical University,Harbin 150001,China 3 Management Information System,University of International Business and Economics,Beijing 100029,China 4 Department of Radiology,Cambridge University Hospitals NHS Foundation Trust Box 219 Level 5,Addenbrooke’s Hospital Cambridge CB2 0QQ,UK | 2010 | Science China(Life Sciences)2010，53，1： | 10 |
| 2 | Differences in atheroma between Caucasian and Asian subjects with anterior stroke:A vessel wall MRI study显示文摘Background and purpose While extracranial carotid artery stenosis is more common among Caucasians and intracranial artery stenosis is more common among Asians,the differences in atherosclerotic plaque characteristics have not yet been extensively examined.We sought to investigate plaque location and characteristics within extracranial carotid and intracranial arteries in symptomatic Caucasians and Chinese using vessel wall MRI.Methods Subjects with recent anterior circulation ischaemic stroke were recruited and imaged at two sites in the USA and China using similar protocols.Both extracranial carotid and intracranial arteries were reviewed to determine plaque location and characteristics.Results The prevalence of extracranial carotid plaque in Caucasians and Chinese was 73.1%and 49.1%,respectively(p=0.055).Prevalence of intracranial plaque was 38.5%and 69.1%in Caucasians and Chinese,respectively(p=0.02).Furthermore,42% of Caucasians and 16%of Chinese had high-risk plaque(HRP)features(intraplaque haemorrhage,luminal surface disruption)in the extracranial carotid artery(p=0.03).The prevalence of HRP features in intracranial arteries was not significantly different between the two cohorts(4%vs 11%;p=0.42).Conclusions Differences in the location and characteristics of cerebrovascular atherosclerosis were identified by vessel wall MRI in US Caucasian and Chinese subjects with recent anterior circulation ischaemic stroke.Extracranial carotid plaques with HRP features were more common in Caucasians.Intracranial plaques were more common in Chinese subjects,but no significant difference between the two cohorts in intracranial HRP prevalence was found.Larger studies using vessel wall imaging to investigate racial differences in cerebrovascular disease may inform underlying mechanisms of HRP development and may ultimately help guide appropriate therapy. | Hiroko Watase Mi Shen Binbin Sui Peiyi Gao Dong Zhang Jie Sun Niranjan Balu Daniel S Hippe Gail P Jarvik Xihai Zhao Rui Li Shuo Chen Chun Yuan Thomas S Hatsukami | 2021 | Stroke & Vascular Neurology2021，6，1： | 4 |
| 3 | Providing Distributed Certificate Authority Service in Cluster-based Mobile Ad Hoc Networks显示文摘 | Dong Y Sui Ai-fen Yiu S M | 2007 | Computer Communications2007，30，1112： | 1 |
| 4 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 5 | gctopic expression of the Coleus R2R3 MYB-Type proanthocyanidin regulator gene SsMYB3 alters the flower color in transgenic tobacco显示文摘 | ZHU Q SUI S LEI X etal | 2015 | PLoS One2015，10，01： | 1 |
| 6 | Ductile titanium alloy with low poission's ratio显示文摘 | HAO Y L LI S J SUN B B SUI M L YANG R | 2007 | Phys Rev Lctt2007，98，21： | 1 |
| 7 | Dye-sensitized solar cells, from cell to module 显示文摘 | Dai S Y Weng J J Sui Y F | 2004 | Sol Energy Mater Sol Cells2004，84，： | 1 |
| 8 | Dielectric properties and conductivity of carbon nanofiber/semi-crystalline polymer com- posites显示文摘 | SUI G JANA S ZHONG W H | 2008 | Acta Materialia2008，56，10： | 1 |
| 9 | Role of life style and aging on the longitudinal change in cardiorespiratory fitness显示文摘 | ACLS ANDREW S JACKSON XUEMEI SUI JAMES R HE BERT | 2009 | Arch Int Ern Med2009，169，19： | 1 |
| 10 | Identification of cyst nematodes of agronomic and regulatory concern with PCR-RFLP of ITSI显示文摘 | Szalanski A Sui D D Harris T S | 1997 | Journal of Nematology1997，29，4： | 1 |
| 11 | Investigation of etiology,diagnosis and treatment of obstetric depression显示文摘 | CUI C S SUI J I HART D | 2005 | Prog Obstet Gynecol2005，14，4： | 1 |
| 12 | Structure and functional ba ses for broad-spectrum neutralization of avian and human influ- enza A viruses显示文摘 | Sui J Hwang WC Perez S | 2009 | Nat Struct Mol Biol2009，16，： | 1 |
| 13 | Cocuhure with cumulus cells improves maturation of mouse oocytes denuded of the cu- mulus oophorus : observations of nuclear and cytoplasmic events 显示文摘 | GE L SUI H S LAN G C | 2008 | Fertility Sterility2008，90，： | 1 |
| 14 | Structural requirements for intracellular transport of pulmonary surfactant protein B (SP-B)显示文摘 | Sui L Phillips K S Wilder M R | 1996 | Biochim Biophys Acta1996，1312，： | 1 |
| 15 | Modelling and simulations of carbon corrosion during operation of a polymer electrolyte membrane fuel cell 显示文摘 | Hu Jingwei Sui P C Kumar S | 2009 | Electrochemica Acta2009，54，23： | 1 |
| 16 | COX 2 contributes to P-glycoprotein-mediated multidrug resistance via phosphorylation of c-Jun at Ser63/73 in colorectal cancer显示文摘 | Sui H Zhou S Wang Y | 2011 | Carcinogenesis2011，32，5： | 1 |
| 17 | Occurrence and remov-al of pharmaceuticals, caffeine and DEET in wastewater treatment plants of Beijing, China显示文摘 | Sui Q Huang J Deng S B | 2010 | Water Res2010，44，2： | 1 |
| 18 | Pulsatile culture of a poly(DL-lactic-co-glycolic acid) sandwiched cel/hydrogel construct fabricated using a step-by-step mold/extraction method显示文摘 | Wang X Sui S | | 0，，06： | 1 |
| 19 | Mechanical properties of potassium titanate whiskers reinforced poly(ether ether ketone)composites using different compounding processes显示文摘 | Zhuang G S Sui G X Meng H | 2006 | Composites Science and Technology In Press Available online2006，27，： | 1 |
| 20 | Dye-sensitized solar cells,from cell to module显示文摘 | Dai S Y Weng J sui Y F | 2004 | Sol Energy Mater Sol Cells2004，84，： | 1 |
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