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| 1 | Affinity peptide developed by phage display selection for targeting gastric cancer显示文摘AIM:To develop an affinity peptide that binds to gastric cancer used for the detection of early gastric cancer.METHODS:A peptide screen was performed by biopanning the PhD-12 phage display library,clearing non-specific binders against tumor-adjacent normal appearing gastric mucosa and obtaining selective binding against freshly harvested gastric cancer tissues.Tumortargeted binding of selected peptides was confirmed by bound phage counts,enzyme-linked immunosorbent assay,competitive inhibition,fluorescence microscopy and semi-quantitative analysis on immunohistochemistry using different types of cancer tissues.RESULTS:Approximately 92.8% of the non-specific phage clones were subtracted from the original phage library after two rounds of biopanning against normal-appearing gastric mucosa.After the third round of positive screening,the peptide sequence AADNAKTKSFPV(AAD) appeared in 25%(12/48) of the analyzed phages.For the control peptide,these values were 6.8 ± 2.3,5.1 ± 1.7,3.5 ± 2.1,4.6 ± 1.9 and 1.1 ± 0.5,respectively.The values for AAD peptide were statistically signif icant(P < 0.01) for gastric cancer as compared with other histological classif ications and control peptide.CONCLUSION:A novel peptide is discovered to have a specific binding activity to gastric cancer,and can be used to distinguish neoplastic from normal gastric mucosa,demonstrating the potential for early cancer detection on endoscopy. | Wen-Jie Zhang Yan-Xia Sui Arun Budha Jian-Bao Zheng Xue-Jun Sun Ying-Chun Hou Thomas D Wang Shao-Ying Lu | 2012 | World Journal of Gastroenterology2012，18，17： | 12 |
| 2 | The TIL commissioning and performance显示文摘 | X Zhang W Zheng X Wei F Jing Z Sui K Zheng Q Xu X Yuan X Jiang L Yang P Ma M Li J Wang D Hu S He F Li Z Peng B Feng H Zhou L Guo X Li X Zhang J Su Q Zhu H Yu R Zhao C Ma H He D Fan W Zhang | 2008 | Journal of Physics: Conference Series2008，，3： | 1 |
| 3 | Decomposition principle in model predictive control for linear s:lstems with bounded disturb-ances 显示文摘 | SUI D FENG L HOVD M | 2009 | Automatica2009，45，8： | 1 |
| 4 | The wikification of GIS and its consequences:Or Angelina Jolie' s new tattoo and the future of GIS 显示文摘 | Sui D | 2008 | Computers Environment and Urban Systems2008，32，1： | 1 |
| 5 | Transdifferentiation of human peripheral blood CD34 ^+ -enriched cell population into cardimnyocytes, endothelial cells, and smooth muscle cells to vivo显示文摘 | Yeh ET Zhang Sui Wu Henry D | 2003 | Circulation2003，108，17： | 1 |
| 6 | Laser texturing of rollers by pulsed Nd: YAG laser 显示文摘 | Du D He Y F Sui B | 2005 | Journal of Materials Processing Technology2005，161，： | 1 |
| 7 | Decomposition principle in model predictive control for linear systems with bounded disturbances显示文摘 | SUI D FENG L HOVD M | 2009 | Automatica2009，45，8： | 1 |
| 8 | Identification of cyst nematodes of agronomic and regulatory concern with PCR-RFLP of ITSI显示文摘 | Szalanski A Sui D D Harris T S | 1997 | Journal of Nematology1997，29，4： | 1 |
| 9 | Extending the Two-Dimensional FDTD Method to Hybrid Electromagnetic Systems with Active and Passive Lumped Elements 显示文摘 | Sui W Chirstensen D A Durney C H | 1992 | IEEE Trans Microwave Theory tech1992，40，4： | 1 |
| 10 | Investigation of etiology,diagnosis and treatment of obstetric depression显示文摘 | CUI C S SUI J I HART D | 2005 | Prog Obstet Gynecol2005，14，4： | 1 |
| 11 | Affinity chromatogra- phy of trypsin using chitosan as ligand support 显示文摘 | Shi Y C Jiang Y M Sui D X | 1996 | Journal of Chromatography A1996，742，： | 1 |
| 12 | Adrenal metasteetomy is safe in selected patients显示文摘 | ROMERO ARENAS MA SUI D GRUBBS EG | 2014 | World J Surg2014，，： | 1 |
| 13 | Examination of the secondary structure of protein by deconvolved FT - IR spectra显示文摘 | BYLER D M SUIS H | 1986 | Biopolymers1986，25，2： | 1 |
| 14 | Laser texturing of rollers by pulsed Nd: YAG laser显示文摘 | Du D He Y F Sui B | 2005 | Journal of Materials Processing Technology2005，161，3： | 1 |
| 15 | Decomposition principle in model predictive control for linear systems with bounded disturb- ances 显示文摘 | SUI D FENG L HOVD M | 2009 | Automatica2009，45，8： | 1 |
| 16 | Identification of cyst nematodes of agronomic and regulatory concern with PCR-RFLP of ITSI显示文摘 | Szalanski A Sui D D Harris T S | 1997 | Journal of Nematology1997，29，4： | 1 |
| 17 | Association of vitamin D levels with outcome in patients with melanoma after adjustment for C-reactive protein显示文摘 | Fang S Sui D Wang Y | 2016 | J Clin Onco2016，34，15： | 1 |
| 18 | Major coronary anomalies in childhood显示文摘 | Vercruysse T Suys B | 2002 | Eur J Pediatr2002，161，12： | 1 |
| 19 | Bulk metallic glass formation in the binary Cu-Zr system显示文摘 | WANG D LI Y SUN B B SUI M L LU K MAB E | 2004 | Applied Physics Letters2004，84，20： | 1 |
| 20 | Integrating GIS with hydrological modeling:practices,problems,and prospects显示文摘 | SUI D Z MAGGIO R C | 1999 | Computers Environment and Urban Systems1999，23，： | 1 |
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