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| 1 | Abnormal liver chemistries as a predictor of COVID-19 severity and clinical outcomes in hospitalized patients显示文摘BACKGROUND Abnormal liver chemistries are common findings in patients with Coronavirus Disease 2019(COVID-19).However,the association of these abnormalities with the severity of COVID-19 and clinical outcomes is poorly understood AIM We aimed to assess the prevalence of elevated liver chemistries in hospitalized patients with COVID-19 and compare the serum liver chemistries to predict the severity and in-hospital mortality.METHODS This retrospective,observational study included 3380 patients with COVID-19 who were hospitalized in the Johns Hopkins Health System(Baltimore,MD,United States).Demographic data,clinical characteristics,laboratory findings,treatment measures,and outcome data were collected.Cox regression modeling was used to explore variables associated with abnormal liver chemistries on admission with disease severity and prognosis RESULTS A total of 2698(70.4%)had abnormal alanine aminotransferase(ALT)at the time of admission.Other more prevalent abnormal liver chemistries were aspartate aminotransferase(AST)(44.4%),alkaline phosphatase(ALP)(16.1%),and total bilirubin(T-Bil)(5.9%).Factors associated with liver injury were older age,Asian ethnicity,other race,being overweight,and obesity.Higher ALT,AST,T-Bil,and ALP levels were more commonly associated with disease severity.Multivariable adjusted Cox regression analysis revealed that abnormal AST and T-Bil were associated with the highest mortality risk than other liver injury indicators during hospitalization.Abnormal AST,T-Bil,and ALP were associated with a need for vasopressor drugs,whereas higher levels of AST,T-Bil,and a decreased albumin levels were associated with mechanical ventilation CONCLUSION Abnormal liver chemistries are common at the time of hospital admission in COVID-19 patients and can be closely related to the patient’s severity and prognosis.Elevated liver chemistries,specifically ALT,AST,ALP,and T-Bil levels,can be used to stratify risk and predict the need for advanced therapies in these patients. | Arunkumar Krishnan Laura Prichett Xueting Tao Saleh A Alqahtani James P Hamilton Esteban Mezey Alexandra T Strauss Ahyoung Kim James J Potter Po-Hung Chen Tinsay A Woreta | 2022 | World Journal of Gastroenterology2022，28，5： | 2 |
| 2 | High levels of population differentiation for mitochondrial DNA haplotypesin Pinus radiata显示文摘 | Strauss S H Hong Y P Hipkins V D | | 0，，： | 1 |
| 3 | Role of ultrasound - guidedfine - needle aspiration biopsy in evaluation of nonpalpable thyroidnodules显示文摘 | HAGAG P STRAUSS S WEISS M | 1998 | Thyroid1998，8，11： | 1 |
| 4 | An investi- gation of personality similarity effects (relational and perceived) on peer and supervisor ratings and the role of familiarity and liking 显示文摘 | Strauss J P Barrick M R Connerley M L | 2001 | Journal of Occupational and Organizational Psychology2001，74，5： | 1 |
| 5 | Stability and instability of solitary waves of Korteweg -de Vries type equation 显示文摘 | BONA J SOUGANIDIS P STRAUSS W | 1987 | Pro- ceeding Royal Society London1987，411，： | 1 |
| 6 | A new wafer level coating technique to reduce the color distribution of LEDs显示文摘 | Braune B Petersen K Strauss J Kromotis P Kaempf M | | 0，，： | 1 |
| 7 | Detection of gas in sandstone reservoirs using AVO analysis: A 3-D seismic case history using the geostack technique显示文摘 | Fatti J Smith G Vail P Strauss P Levitt P | 1994 | Geophysics1994，59，： | 1 |
| 8 | No association between brain-derived neurotrophic factor gene and obsessivecompulsive disorder显示文摘 | ZAI G ARNOLD P STRAUSS J | 2005 | Psychiatr Genet2005，15，4： | 1 |
| 9 | Polymers in aqueous media:Performance through association显示文摘 | Strauss U P | 1951 | J Polymer Sci1951，6，5： | 1 |
| 10 | Hydroxylated linalool derivatives as percursors of volatile monoterpenes of Muscat grapes显示文摘 | Williams P J Strauss C R Wilson B | 1980 | J Agric Food Chem1980，28，： | 1 |
| 11 | Viscosity of sodium salt of polyuronide hemicellulose from Jute显示文摘 | Strauss U P | 1952 | J Polymer Sci1952，7，6： | 1 |
| 12 | A case of childhood dermatofibrosarcoma protuberans without detected cytogenetic abnormality显示文摘 | Strauss R M Merchant W J Roberts P | 2003 | Br J Dermatol2003，148，5： | 1 |
| 13 | Conscientiousness and Performance of Sales Representatives:Test of the Me- diating Effects of Goal Setting显示文摘 | Barrick M R Mount M K Strauss J P | 1993 | Journal of Applied Psy- chology1993，78，5： | 1 |
| 14 | The distribution of free and glycosidically bound monoterpenes among skin, juice and pulp fractions of some grape varieties显示文摘 | Wilson B Strauss C R Williams P J | 1986 | American Journal of Enology and Viticulture1986，37，： | 1 |
| 15 | Polyphosphates as polyelectrolytes I light scattering and viscosity of sodium polyphosphates in electrolyte solutions 显示文摘 | STRAUSS U P SMITH E H WINEMAN P L | 1953 | American Chemical Society1953，75，16： | 1 |
| 16 | Conscien- tiousness and Representatives: Test of the Mediating Effect of Goal Setting 显示文摘 | Barfick M R Mount M K Strauss J P | 1993 | Journal of Applied Psy- chology1993，78，6： | 1 |
| 17 | Matrix attachment regions (MARs) enhance transformation frequency and transgene expression in poplar显示文摘 | Han K H Ma C P Strauss S H | 1997 | Transgenic Research1997，6，： | 1 |
| 18 | Hydrophobic Hypercoiling in Copoly- mers of Maleic Acid and Alkyl Vinyl Ethers 显示文摘 | Dupin P Strauss U P | 1967 | JPhys Chem1967，71，8： | 1 |
| 19 | ^87Sr/^86Sr, δ^13C and δ^18O evolution of Phanerozoic seawater 显示文摘 | Veizer J Ala D Azmy K Bruckschen P Buhl D Bruhn F Carden G A F Diener A Ebneth S Godderis Y Jasper T Korte C Pawellek F Podlaha O G Strauss H | 1999 | Chem Geol1999，161，13： | 1 |
| 20 | Volume changes as acriterion for site binding of counterions by polyelectrolytes显示文摘 | STRAUSS U P LEUNG Y P | 1965 | Journal of the American Chemical Society1965，87，7： | 1 |
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