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| 1 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 2 | The role of antioxidants and pro-oxidants in colon cancer显示文摘This review focuses on the roles antioxidants and prooxidants in colorectal cancer(CRC).Considerable evidence suggests that environmental factors play key roles in the incidence of sporadic CRC.If pro-oxidant factors play an etiological role in CRC it is reasonable to expect causal interconnections between the wellcharacterized risk factors for CRC,oxidative stress and genotoxicity.Cigarette smoking,a high dietary consumption of n-6 polyunsaturated fatty acids and alcohol intake are all associated with increased CRC risk.These risk factors are all pro-oxidant stressors and their connections to oxidative stress,the intestinal microbiome,intestinal microfold cells,cyclooxygenase-2 and CRCare detailed in this review.While a strong case can be made for pro-oxidant stressors in causing CRC,the role of food antioxidants in preventing CRC is less certain.It is clear that not every micronutrient with antioxidant activity can prevent CRC.It is plausible,however,that the optimal food antioxidants for preventing CRC have not yet been critically evaluated.Increasing evidence suggests that RRR-gamma-tocopherol(the primary dietary form of vitamin E)or other'non-alpha-tocopherol'forms of vitamin E(e.g.,tocotrienols)might be effective.Aspirin is an antioxidant and its consumption is linked to a decreased risk of CRC. | William L Stone Koyamangalath Krishnan Sharon E Campbell Victoria E Palau | 2014 | World Journal of Gastrointestinal Oncology2014，6，3： | 4 |
| 3 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 4 | 连续油管电缆安装系统的开发显示文摘开发出了一个可以缠绕在卷筒上的连续油管内注入、注出电力电缆安装系统。介绍了该安装系统的油田需求、开发此系统所用理论、该安装系统的各部分装置以及应用案例。该电缆安装系统工作压力为51.72 MPa(7 500 psi),与以前的安装方法相比,大大降低了电缆安装成本,完全满足在较长连续油管内安装电缆的需求。 | 杨社民 NEWMAN K R HAVER N A STONE L R | 2015 | 焊管2015，38，10： | 2 |
| 5 | Theoretical examination of the pulse vaccination policy in the SIR epidemic model 显示文摘 | Stone L Shulgin B Agur Z | 2000 | Mathematical Computer Modeling2000，31，45： | 1 |
| 6 | HAESA, an Arabidopsis leucinerich repeat receptor kinase, controls floral organ abscission 显示文摘 | Lin T L Stone J Walker J | 2000 | Genes Dev2000，14，： | 1 |
| 7 | Computer aided design of experiments显示文摘 | Kennard R W Stone L A | 1969 | Technometrics1969，11，： | 1 |
| 8 | Cellular proteins in influenza virus particles显示文摘 | Shaw Megan L Stone Kathryn L Colangelo Christopher M | 2008 | PLoS pathogens2008，4，10： | 1 |
| 9 | Development of a Functional Basis for Design显示文摘 | Stone R B Wood K L | 2000 | Journal of Mechanical Design2000，122，4： | 1 |
| 10 | Form and function of arabinogalactans and arabinogalactanproteins显示文摘 | Clarke A E Anderson R L Stone B A | 1979 | Phytochemistry1979，18，： | 1 |
| 11 | Poliovirus escape from RNA interference:short interfering RNA-target recognition and implications for therapeutic approaches显示文摘 | Gitlin L Stone JK Andino R | 2005 | J Viro12005，79，2： | 1 |
| 12 | The molecular basis for inhibition of adipose conversion of murine 3T3-L1 cells by retinoic acid显示文摘 | Stone R L Bernlohr D A | 1990 | Differentiation1990，45，2： | 1 |
| 13 | Probability model for estimating three - phase relative permeability 显示文摘 | Stone H L | 1970 | Journal of Petroleum Technology1970，22，2： | 1 |
| 14 | Computer aided design of experiments 显示文摘 | Kennard R W Stone L A | 1969 | Technometrics1969，11，1： | 1 |
| 15 | Theoretical exami-nation of the pulse vaccination policy in the SIR epi-demic model显示文摘 | Stone L Shulgin B Agur Z | | 0，，04： | 1 |
| 16 | Unexpected epidemic thresholds in heterogeneous networks: the role of disease transmission 显示文摘 | Olinky R Stone L | 2004 | Physical Review E2004，70，03： | 1 |
| 17 | Effectiveness of barrier precautions and surveillance cultures to control transmission of multidrug-resistant organisms:a systematic review of the literature显示文摘 | Aboelela S W Saiman L Stone P | 2006 | Am J Infect Control2006，34，8： | 1 |
| 18 | Structure-function relations of heparin-mimetic sulphated xylan-oligosaccharides inhibition of Human Immunodeficiency Virus-1 infectivity in vitro显示文摘 | Stone A L Melton D J Lewis M S | 1998 | GlycoconjugateJournal1998，15，： | 1 |
| 19 | Submeter spatial variability of selected soil and bermudagrass production variables显示文摘 | Solie J B Raun W R Stone M L | 1999 | Soil Sci Soc Am J1999，63，： | 1 |
| 20 | Thoretical examination of the pulse vaccination policy in the SIR epidemic model显示文摘 | Shulgin B Agur Z | 2000 | Mathematical and Computer Modelling2000，，31： | 1 |
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