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| 1 | Percutaneous left atrial appendage closure:Technical aspects and prevention of periprocedural complications with the watchman device显示文摘Transcatheter closure of the left atrial appendage has been developed as an alternative to chronic oral anticoagulation for stroke prevention in patients with atrial fibrillation, and as a primary therapy for patients with contraindications to chronic oral anticoagulation. The promise of this new intervention compared with warfarin has been supported by several, small studies and two pivotal randomized trial with the Watchman Device. The results regarding risk reduction for stroke have been favourable although acute complications were not infrequent. Procedural complications, which are mainly related to transseptal puncture and device implantation, include air embolism, pericardial effusions/tamponade and device embolization. Knowledge of nature, management and prevention of complications should minimize the risk of complications and allow transcatheter left atrial appendage closure to emerge as a therapeutic option for patients with atrial fibrillation at risk for cardioembolic stroke. | Sven M bius-Winkler Nicolas Majunke Marcus Sandri Norman Mangner Axel Linke Gregg W Stone Ingo D hnert Gerhard Schuler Peter B Sick | 2015 | World Journal of Cardiology2015，7，2： | 14 |
| 2 | Leukemia:研究鉴定出与34种AML白血病亚群相关联的基因突变显示文摘针对成年急性髓细胞白血病(acute myeloid leukemia,AML)患者的一项新的大型研究将80种癌症相关基因突变与5种AML亚型相关联。这5种AML亚型可通过特异性的染色体异常加以确定。在未来,这些发现可能有助指导基因突变测试和治疗决策。 | A-K Eisfeld K Mrózek J Kohlschmidt D Nicolet S Orwick C J Walker K W Kroll J S Blachly A J Carroll J E Kolitz B L Powell E S Wang R M Stone A de la Chapelle J C Byrd C D Bloomfield | 2017 | 现代生物医学进展2017，17，15： | 7 |
| 3 | Dyslipidemia management in primary prevention of cardiovascular disease:Current guidelines and strategies显示文摘Cardiovascular disease is the leading cause of death in the United States. In 2010, the Centers for Disease Control and Prevention estimated that $444 billion was spent on cardiovascular diseases alone, about $1 of every $6 spent on health care. As life expectancy continues to increase, this annual cost will also increase, making costeffective primary prevention of cardiovascular disease highly desirable. Because of its role in development of atherosclerosis and clinical events, dyslipidemia management is a high priority in cardiovascular prevention. Multiple major dyslipidemia guidelines have been published around the world recently, four of them by independent organizations in the United States alone. They share the goal of providing clinical guidance on optimal dyslipidemia management, but guidelines differ in their emphasis on pharmacotherapy, stratification of groups, emphasis on lifestyle modification, and use of a fixed target or percentage reduction in low density lipoprotein cholesterol. This review summarizes eight major guidelines for dyslipidemia management and considers the basis for their recommendations. Our primary aim is to enhance understanding of dyslipidemia management guidelines in patient care for primary prevention of future cardiovascular risk. | Aditya D Hendrani Tolulope Adesiyun Renato Quispe Steven R Jones Neil J Stone Roger S Blumenthal Seth S Martin | 2016 | World Journal of Cardiology2016，8，2： | 5 |
| 4 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 5 | Combination of corticosteroids and 5-aminosalicylates or corticosteroids alone for patients with moderate-severe active ulcerative colitis:A global survey of physicians'practice显示文摘AIM To examine treatment decisions of gastroenterologists regarding the choice of prescribing 5-aminosalycilates(5ASA) with corticosteroids(CS) versus corticosteroids alone for patients with active ulcerative colitis(UC). METHODS A cross-sectional questionnaire exploring physicians' attitude toward 5ASA + CS combination therapy vs CS alone was developed and validated. The questionnaire was distributed to gastroenterology experts in twelve countries in five continents. Respondents' agreement with stated treatment choices were assessed by standardized Likert scale. Background professional characteristics of respondents were analyzed for correlation with responses. RESULTS Six hundred and sixty-four questionnaires were distributed and 349 received(52.6% response rate). Of 340 eligible respondents, 221(65%) would continue 5ASA in a patient hospitalized for intravenous CS treatment due to a moderate-severe UC flare, while 108(32%) would stop the 5ASA(P < 0.001), and 11(3%) are undecided. Similarly, 62% would continue 5ASA in an out-patient starting oral CS. However, only 140/340(41%) would proactively start 5ASA in a hospitalized patient not receiving 5ASA before admission. Most(94%) physicians consider the safety profile of 5ASA as very good. Only 52% consider them inexpensive, 35% perceive them to be expensive and 12% are undecided. On multi-variable analysis, less years of practice and perception of a plausible additive mechanistic effect of 5ASA + CS were positively associated with the decision to continue 5ASA with CS. CONCLUSION Despite the absence of data supporting its benefit, most gastroenterologists endorse combination of 5ASA + CS for patients with active moderate-to-severe UC. Randomized controlled trials are needed to assess if 5ASA confer any benefit for these patients. | Shomron Ben-Horin Jane M Andrews Konstantinos H Katsanos Florian Rieder Flavio Steinwurz Konstantinos Karmiris Jae Hee Cheon Gordon William Moran Monica Cesarini Christian D Stone Doron Schwartz Marijana Protic Xavier Roblin Giulia Roda Min-Hu Chen Ofir Har-Noy Charles N Bernstein | 2017 | World Journal of Gastroenterology2017，23，16： | 3 |
| 6 | Selective detection of aroma compontents by acoustic wave sensors coated with conducting polymers films显示文摘 | Deng Z P Stone D C Thompson M | | Analyst0，121，： | 2 |
| 7 | Catalysis at the metal-support interface: exemplified by the photocatalytic reforming of methanol on Pd/TiO2显示文摘 | BOWKER M JAMES D STONE P | 2003 | J Catal2003，217，2： | 2 |
| 8 | Enhanced 3He/4He ratios and cosmogenic helium in ultramafic xenoliths 显示文摘 | Porcelli D R Stone JOH O′Nions R K | 1987 | Chem Geol1987，64，： | 2 |
| 9 | Outcome in elderly patients undergoing primary coronary intervention for acute myocardial infarction: results from the Controlled Abciximab and Device Investigation to Lower Late Angioplasty Complications ( CADILLAC ) trial 显示文摘 | Guagliumi G Stone G W Cox D A | 2004 | Circulation2004，110，12： | 1 |
| 10 | The molecular basis for inhibition of adipose conversion of murine 3T3-L1 cells by retinoic acid显示文摘 | Stone R L Bernlohr D A | 1990 | Differentiation1990，45，2： | 1 |
| 11 | A muhl-model update on the detection and attribution of global surface warming显示文摘 | Stone D A Allen M R Stott P A | 2007 | Journal of Climate2007，20，： | 1 |
| 12 | Percutaneous coronary intervention versus coronary artery bypass graft surgery in left main coronary artery disease:a meta-analysis of randomized clinical data显示文摘 | Capodanno D Stone GW Morice MC | | 0，，14： | 1 |
| 13 | Clinical features and management of splenic arterypseudoaneurysm: Case series and cumulative review of literature 显示文摘 | Tessier D J Stone WM Fowl R J | 2003 | J Vasc Surg2003，38，5： | 1 |
| 14 | All Currently Used Measurements of Recirculation in Blood Access by Chemical Methods Are Flawed Due to Intradialytic Disequilibrium or Recirculation at Low Flow显示文摘 | Twardowski Z J Stone J V Haynie J D | 1998 | American Journal of Kidney Diseases1998，32，6： | 1 |
| 15 | Interaction of themaize and Arabidopsis kinase interaction domains with a subset of receptor-like protein kinases,implications for transmembrane signalling in plants显示文摘 | Braun D M Stone J M Walker J C | 1997 | Plant J1997，12，： | 1 |
| 16 | Structure-function relations of heparin-mimetic sulphated xylan-oligosaccharides inhibition of Human Immunodeficiency Virus-1 infectivity in vitro显示文摘 | Stone A L Melton D J Lewis M S | 1998 | GlycoconjugateJournal1998，15，： | 1 |
| 17 | A novel wave guide-to-microstrip transition for millimeter-wave module applications显示文摘 | VILLEGAS F J STONES D I HUNG H A | 1999 | IEEE MTT1999，47，1： | 1 |
| 18 | A vibration technique for non - destructive assessing the integrity of structures显示文摘 | Cawley P Pye C J Stone B J | 1978 | Journal of Mechanical Engineering Science1978，20，： | 1 |
| 19 | Discovery of 'selfsynergistic' spinal/surpraspinal antinociception produced by acetaminophen (pamcetamol) 显示文摘 | Raffa R B Stone D J Tallarida R J | 2000 | J Pharmacol Exp Ther2000，295，1： | 1 |
| 20 | Analysis of in vitro lymphocyte proliferation as a screening tool for cellular immunodeficiency 显示文摘 | Stone K D Feldrnan HA Huisman C | 2009 | Clin Immunol2009，131，： | 1 |
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