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| 1 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 2 | 子宫炎性肌纤维母细胞肿瘤通常存在ALK与IGFBP5和THBS1基因的融合显示文摘炎性肌纤维母细胞肿瘤能够发生在包括子宫在内的多个解剖部位。子宫炎性肌纤维母细胞肿瘤与发生在软组织的炎性肌纤维母细胞肿瘤相似,也通常表达ALK,并存在ALK基因重排。该文着重分析子宫炎性肌纤维母细胞肿瘤的基因融合特征。 | Haimes J D Stewart C J R Kudlow B A 赵芳 魏建国 | 2018 | 临床与实验病理学杂志2018，34，1： | 2 |
| 3 | A contingency perspective on organizational learning: integrating environment context, organizational learning processes and types of learning 显示文摘 | GNYAWALI D R STEWART A C | 2003 | Management learning2003，34，1： | 1 |
| 4 | Cardiovascular risk factors and cognitive decline in adults aged 50 and over:a population-based cohort study显示文摘 | Dregan A Stewart R Gulliford MC | 2013 | Age Ageing2013，42，3： | 1 |
| 5 | Vasopressors for the treat- ment of maternal hypotension following spinal anaesthesia for e- lective caesarean section: past, present and future显示文摘 | Heesen M Stewart A Fernando R | 2015 | Anaesthe- sia2015，70，3： | 1 |
| 6 | Influence of nitrogen source and availability on amino acids pigments and tissue nitrogen of Gracilaria eduils (Rhodophyta) 显示文摘 | Dennison W C Stewart G R | 1996 | J Phycol1996，32，： | 1 |
| 7 | Joint PP and PS seismic inversion显示文摘 | Margrave G F Stewart R R Larsen J A | 2001 | The Leading Edge2001，20，： | 1 |
| 8 | The Role of Climate for Innovation in En- hancing Business Performance: The Case of Design Firms显示文摘 | PANUWATWANICH K STEWART R A MO- HAMED S | 2008 | Engineering Construction and Architectur- al Management2008，15，5： | 1 |
| 9 | Phosphonates as mimics of phosphate biomolecules: ab initio calculations on tetrahedral ground states and pentacoordinate intermediates for phosphoryl transfer显示文摘 | Gegory R J Thatcher A Stewart Campbell | 1993 | J Org Chem1993，58，8： | 1 |
| 10 | An improved in vivo method for atrioventricu lar node ablation via thoracotomy显示文摘 | Maciver R H Stewart R D Backer C L Tsao S Harrington D A Mavroudis C | 2010 | Braz J Med Biol Res2010，43，： | 1 |
| 11 | Do sporting activities convey benefite to bone mass throughout the skeleton 显示文摘 | Newill A Holder R Stewart A | 2004 | J Sports Sci2004，22，7： | 1 |
| 12 | Growth of alligator weed (A lternanthera philoxeroides)and population development of Agasicles hygrophila in northern New Zealand显示文摘 | Stewart C A Chapman R B Frampton C M A | 2000 | Plant Protection Quarterly2000，15，1： | 1 |
| 13 | Medical treatment of asymptomatic chronic aortic regurgitation显示文摘 | Lin A Stewart R | 2011 | Expert Rev Cardiovasc Ther2011，9，9： | 1 |
| 14 | A Bayesian approach for modelling non-linear longitudinal/hierarchical data with random effects in forestry显示文摘 | Li R Stewart B Weiskittel A | 2012 | Forestry2012，85，1： | 1 |
| 15 | Telomeres: cancer to human aging 显示文摘 | Stewart S A Weinberg R A | 2006 | Annu Rev Cell Dev Biol2006，22，： | 1 |
| 16 | Comparative growth and yield of cotton grown in various densities and configura- tions 显示文摘 | SEIBERT J D STEWART A M LEONARD B R | 2006 | Agron J2006，98，： | 1 |
| 17 | Self-reported truck traffic on the street of residence and symptoms of asthma and allergic disease: A glob- al relationship in ISAAC phase 3 显示文摘 | Brunekreef B Stewart A W Anderson H R | 2009 | Environmental Health Perspectives2009，117，11： | 1 |
| 18 | Age, vascular risk, and cognitive decline in an older British African Caribbean population显示文摘 | Stewart R Prince M Mann A | 2003 | Am Geriatr Soc2003，51，11： | 1 |
| 19 | Evidence suggesting that a chronic disease self-management pro- gram can improve health status while reducing hospitali- zation: a randomized trial显示文摘 | Lorig K R Sobel D S Stewart A L | 1999 | Med Care1999，37，1： | 1 |
| 20 | Temporal variability in terrestrially-derived sources of particulate organic carbon in the lower Mississippi River and its upper tributaries 显示文摘 | Bianchi T S Wysocki L A Stewart M Filley T R McKee B A | 2007 | Geochim Cosmochim Acta2007，71，18： | 1 |
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