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| 1 | HPV阴性胃型子宫颈原位腺癌:一种具有胃和肠分化的罕见病变谱系显示文摘作者报道9例罕见的具有胃和肠分化且与人类乳头瘤病毒(HPV)感染无关的子宫颈原位腺癌(AIS)。患者年龄25~73岁(平均51岁),所有病例均位于子宫颈鳞一柱交界区(或邻近),其中有3例延伸子宫下段,2例累及子宫内膜。所有病例均大部分保留正常子宫颈腺体结构,其中5例有轻度腺体复杂性增生。腺上皮从几乎为纯胃型(4例)至混合不同比例杯状细胞的胃肠型(5例)。与正常的子宫颈腺体嗜碱性细胞质不同,胃型上皮通常由明显嗜酸性或浅粉色胞质的细胞组成,但在某些病例中胞质呈明显的泡沫状或透明胞质。所有病例均有核非典型性, | Talia K L Stewart C J R Howitt B E 黄爱清(摘译) 余英豪(审校) | 2017 | 临床与实验病理学杂志2017，33，11： | 19 |
| 2 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 3 | The Changing Cold Regions Network:Observation,diagnosis and prediction of environmental change in the Saskatchewan and Mackenzie River Basins,Canada显示文摘Climate change is causing rapid and severe changes to many Earth systems and processes,with widespread cryospheric,ecological,and hydrological impacts globally,and especially in high northern latitudes.This is of major societal concern and there is an urgent need for improved understanding and predictive tools for environmental management.The Changing Cold Regions Network(CCRN)is a Canadian research consortium with a focus to integrate existing and new experimental data with modelling and remote sensing products to understand,diagnose,and predict changing land,water,and climate,and their interactions and feedbacks over the geographic domain of the Mackenzie and Saskatchewan River Basins in Canada.The network operates a set of 14 unique and focused Water,Ecosystem,Cryosphere and Climate(WECC)observatories within this region,which provide opportunities to observe and understand processes and their interaction,as well as develop and test numerical simulation models,and provide validation data for remote sensing products.This paper describes this network and its observational,experimental,and modelling programme.An overview of many of the recent Earth system changes observed across the study region is provided,and some local insights from WECC observatories that may partly explain regional patterns and trends are described.Several of the model products being developed are discussed,and linkages with the local to international user community are reviewed—In particular,the use of WECC data towards model and remote sensing product calibration and validation is highlighted.Some future activities and prospects for the network are also presented at the end of the paper. | Chris M DEBEER Howard S WHEATER William L QUINTON Sean K CAREY Ronald E STEWART Murray D MACKAY Philip MARSH | 2015 | Science China Earth Sciences2015，58，1： | 5 |
| 4 | Determination of total and speciated arsenic in rice by ion chromatography and inductively coupled plasma mass spectrometry 显示文摘 | HEITKEMPER D T VELA N P STEWART K R | 2001 | J Anal Atom Spectrom2001，16，： | 1 |
| 5 | Structural basis for tropomyosin overlap in thin(actin)filaments and the generation of a molecular swivel by troponin-T显示文摘 | Murakami K Stewart M Nozawa K | 2008 | Proc Natl Acad Sci USA2008，105，20： | 1 |
| 6 | STRO-1,HOP-26 (CD63),CD49a and SB-10(CD166) as markers of primitive human marrow stromal cells and their differentiated progeny: a comparative investigation in vitro 显示文摘 | Stewart K Monk P Walsh S | 2003 | Cell Tissue Res2003，313，3： | 1 |
| 7 | Predictive value of C D lymphocyte numbers for the development of opportunistic infections and malignancies in HIV-infected persons 显示文摘 | Growes S M Carlin J B Stewart K L | 1991 | J Acquir Immune Defic Sydr1991，4，： | 1 |
| 8 | Fusobacterium necrophorum leukotoxin indnces activation and apopotosis of bovine leukocytes显示文摘 | NARAYANAN S K STEWART G C CHENGAPPA M M | 2002 | Infect Immun2002，70，： | 1 |
| 9 | The search for authenticity in the pilgrim experience 显示文摘 | BelhassenY ? Caton K and Stewart K C | 2008 | Annals of Tourism Re-search2008，35，3： | 1 |
| 10 | More 'malignant - than cancer' Five-year survival following a first admission for heart failure显示文摘 | Stewart S MacIntyre K Hole DJ | 2001 | Eur Hear J Fail2001，3，： | 1 |
| 11 | Genetic Discrimination in Australia显示文摘 | Stewart K B Keays D | 2001 | Journal of Law and Medicine2001，8，3： | 1 |
| 12 | Calculation of the nonlinear optical properties of molecules 显示文摘 | Kurtz H A Stewart J J P Dieter K M | 1990 | Journal of Computa- tional Chemistry1990，11，1： | 1 |
| 13 | Evidence of improving prognosis in heart failure:trends in case-fatality in 66,547 patients hospitalized between 1986 and 1995显示文摘 | MacIntyre K Capewell S Stewart S | 2000 | Circulation2000，102，： | 1 |
| 14 | Gon- adotropin-releasing hormone receptor levels and cell context affect tumor cell responses to agonist in vitro and in vivo 显示文摘 | MORGAN K STEWART A J MILLER N | 2008 | Cancer Res2008，68，15： | 1 |
| 15 | Reduction of chromium (VI) at sub-μg 1-1 levels by fulvic acid 显示文摘 | ECKERT J M STEWART J J WAITE T D SZYMCZAK R WILLIAMS K L | 1990 | Analytica Chimica Acta1990，236，： | 1 |
| 16 | The Role of Climate for Innovation in En- hancing Business Performance: The Case of Design Firms显示文摘 | PANUWATWANICH K STEWART R A MO- HAMED S | 2008 | Engineering Construction and Architectur- al Management2008，15，5： | 1 |
| 17 | Modeling price-drivel interactions between wood bioenergy and global woo1 product markets 显示文摘 | Zhang S J Gilless J K Stewart W | 2014 | Biomass and Bioenergy2014，60，： | 1 |
| 18 | Research enrichment:evaluation of structured research in the curriculum for dental medicine students as part of the vertical and horizontal integration of biomedical training and discovery显示文摘 | Kingsley K O'Malley S Stewart T | 2008 | BMC Med Educ2008，8，： | 1 |
| 19 | Biofilm resistance to antimicrobial agents显示文摘 | XU K D McFETERS G A STEWART P S | 2000 | Microbiology2000，146，3： | 1 |
| 20 | Isolation of a cDNA that hybrid selects antiproliferative mRNA from rat liver显示文摘 | McClung J K Danner D B Stewart D A | 1989 | Biochem Biophys1989，16，4： | 1 |
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