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| 1 | Molecular mechanisms of AGE/RAGE-mediated fibrosis in the diabetic heart显示文摘Chronic hyperglycemia is one of the main characteristics of diabetes. Persistent exposure to elevated glucose levels has been recognized as one of the major causal factors of diabetic complications. In pathologies, like type 2 diabetes mellitus(T2DM), mechanical and biochemical stimuli activate profibrotic signaling cascades resulting in myocardial fibrosis and subsequent impaired cardiac performance due to ventricular stiffness. High levels of glucose nonenzymatically react with long-lived proteins, such as collagen, to form advanced glycation end products(AGEs). AGE-modified collagen increase matrix stiffness making it resistant to hydrolytic turnover, resulting in an accumulation of extracellular matrix(ECM) proteins. AGEs account for many of the diabetic cardiovascular complications through their engagement of the receptor for AGE(RAGE). AGE/RAGE activation stimulates the secretion of numerous profibrotic growth factors, promotes increased collagen deposition leading to tissue fibrosis, as well as increased RAGE expression. To date, the AGE/RAGE cascade is not fully understood. In this review, we willdiscuss one of the major fibrotic signaling pathways, the AGE/RAGE signaling cascade, as well as propose an alternate pathway via Rap1 a that may offer insight into cardiovascular ECM remodeling in T2 DM. In a series of studies, we demonstrate a role for Rap1 a in the regulation of fibrosis and myofibroblast differentiation in isolated diabetic and non-diabetic fibroblasts. While these studies are still in a preliminary stage, inhibiting Rap1 a protein expression appears to down-regulate the molecular switch used to activate the ζ isotype of protein kinase C thereby promote AGE/RAGE-mediated fibrosis. | Jia Zhao Rushil Randive James A Stewart | 2014 | World Journal of Diabetes2014，5，6： | 17 |
| 2 | Strategies for increasing the capture, storage, and utilization of precipitation in semiarid regions显示文摘Crop production in semiarid regions is always challenging because of the high variability of amount and distribution of precipitation.These regions become more important each year, however, because the rapidly increasing and more prosperous world population seeks greater consumption of animal products(meat, milk and eggs) that requires additional grain to that consumed directly.The dry areas of the developing world where approximately 40% of the world population lives comprise about 40% of the earth's land area.Crop production, particularly cereal grains, must increase in these areas to meet these growing demands.Grain yield of cereal crops is a function of the amount of water used for evapotranspiration(ET), the portion of ET used for transpiration(T), the units of water as T to produce 1 unit of biomass, and the harvest index(HI).The most important factor is the amount of evapotranspiration not only because it is closely proportional to grain yield, but because it tends to also make the other factors more favorable.Therefore, even small increases in ET can be significant.Strategies for manipulating soil and plant conditions for increasing ET, and how additional ET affects the other factors, are discussed for water deficient areas.The use of crop residues as mulch is highly beneficial but often insufficient in dryland regions or is required for animal feed and fuel.Plastic mulch, mainly restricted to China, has significantly increased grain yields in dryland areas by decreasing evaporation from the soil surface. | B A Stewart LIANG Wei-li | 2015 | Journal of Integrative Agriculture2015，14，8： | 8 |
| 3 | Dynamic chromatin states in human ES cells reveal potential regulatory sequences and genes involved in pluripotency显示文摘Pluripotency,一个细胞的能力区分并且产生所有胚胎的系,定义象胚胎的茎(ES ) 那样的哺乳动物的细胞类型的一个小数字细胞。当它通常被保持了时,那 pluripotency 是 transcriptional 的产品激活并且维持关键干细胞基因的表达式的规章的网络,积累的证据在建立并且保卫 ES 房间的 pluripotency 为 epigenetic 进程正在指向一个关键角色,象维持区分的房间类型的身份一样。以便更好在 pluripotency 理解 epigenetic 机制的角色,我们检验了在经历区别进一个 mesendodermal 系的人的 ES 房间(hESCs ) 染色体宽的染色质修正的动力学。我们发现在倡导者的染色质修正在区别期间仍然保持大部分不变,除了在在在 H3K27 的 acetylation 和 methylation 之间的一个动态开关标记在基因表示的激活和 silencing 之间的转变的倡导者的一个小数字,建议在在大多数差别上的房间命运承诺的一个层次表示了基因。我们也在 50 000 潜在的 enhancers 上印射,并且在染色质修正,特别 H3K4me1 和 H3K27ac 观察了大得多的动力学,它与他们的潜在的目标基因的表示相关。这些 enhancers 的进一步的分析揭示了 pluripotency 和可以在 hESCs 授与发展胜任的一个平衡状态的一口染色质签名陈述语气的潜在地关键的 transcriptional 管理者。我们的结果提供在定义 enhancers 和 pluripotency 支持染色质修正的角色的新证据。 | R David Hawkins Gary C Hon Chuhu Yang Jessica E Antosiewicz-Bourget Leonard K Lee Que-Minh Ngo Sarit Klugman Keith A Ching Lee E Edsall Zhen Ye Samantha Kuan Pengzhi Yu Hui Liu Xinmin Zhang Roland D Green Victor V Lobanenkov Ron Stewart James A Thomson Bing Ren | 2011 | Cell Research2011，21，10： | 6 |
| 4 | Characterization and target identification of a DNA aptamer that labels pluripotent stem cells显示文摘 | Zhonggang Hou Susanne Meyer Nicholas E Propson jeff Nie Peng Jiang Ron Stewart James A Thomson | 2015 | Cell Research2015，25，3： | 5 |
| 5 | 子宫炎性肌纤维母细胞肿瘤通常存在ALK与IGFBP5和THBS1基因的融合显示文摘炎性肌纤维母细胞肿瘤能够发生在包括子宫在内的多个解剖部位。子宫炎性肌纤维母细胞肿瘤与发生在软组织的炎性肌纤维母细胞肿瘤相似,也通常表达ALK,并存在ALK基因重排。该文着重分析子宫炎性肌纤维母细胞肿瘤的基因融合特征。 | Haimes J D Stewart C J R Kudlow B A 赵芳 魏建国 | 2018 | 临床与实验病理学杂志2018，34，1： | 2 |
| 6 | A comparison of size seleetion of haddock and whiting by square and diamond mesh codends显示文摘 | Robertson J H Stewart P A | 1988 | J Cons Int Expl Mer1988，44，： | 2 |
| 7 | 特发性肺间质纤维化患者疱疹病毒感染与血管重塑、肺高血压相关显示文摘肺高血压是特发性肺问质纤维化(idiopathic pulmonary fibrosis,IPF)的主要并发症,对患者预后有不良影响。目前认为疱疹病毒在IPF的发生发展过程中起致病作用。病毒对IPF相关的肺高血压的影响尚不清楚。该研究重点探讨病毒对IPF患者肺高血压相关方面的影响,同时还对γ疱疹病毒[鼠疱疹病毒68(maus herpesvirus 68,MHV-68)]诱发的肺间质纤维化实验室小鼠模型进行评估。 | Calabrese F Kipar A Lunardi F Balestro E Perissinotto E Rossi E Nannini N Marulli G Stewart JP Rea F 刘莉 叶鹏 | 2013 | 中华高血压杂志2013，21，5： | 2 |
| 8 | Extensive butyltin contamination in southwestern coastal British Columbia显示文摘 | Stewart C Thompson J A J | 1994 | Marine Pollution Bulletin1994，28，： | 1 |
| 9 | Hypophosphataemia in general practice 显示文摘 | Guy JM Stewart MF olukoga A | 1999 | Annclin Biochem1999，36，1： | 1 |
| 10 | Droplet dynamics in creeping flows显示文摘 | Stewart M B Morrison F A | 1981 | Journal of Applied Mechanics-Transactions of the ASME1981，48，： | 1 |
| 11 | Sex and ethnic differ- ences in 2rid to 4th digit ratio of child显示文摘 | Manning JT Stewart A Bundred PE | 2004 | Early Human Develop- ment2004，80，： | 1 |
| 12 | Bipanconnectivity and bipancyclici- ty in k-ary n-cubes显示文摘 | Stewart I A Xiang Yonghong | 2009 | IEEE Transactions on Parallel and Distrib-uted Systems2009，20，1： | 1 |
| 13 | pH and concentration of bilirubin in feeding tube aspirates as predictors of tube placement显示文摘 | Metheny N A Stewart B J | 1999 | Nurs Res1999，48，4： | 1 |
| 14 | Proviral insertions induce the expression of bone-specific isoforms of PEBP2alphaA (CBFA1):evidence for a new myc collaborating oncogene显示文摘 | Stewart M Terry A Hu M | 1997 | Proc Natl Acad Sci USA1997，94，16： | 1 |
| 15 | Extremely low frequency plasmons in metallic mesostructures显示文摘 | Pendry J B Holden A J Stewart W J | 1996 | Phys Rev Lett1996，76，23： | 1 |
| 16 | The potential application of plant essential oils as natural food preservatives in soft cheese显示文摘 | Smith-Palmer A Stewart J Fyfe L | 2001 | Food Microbiology2001，18，4： | 1 |
| 17 | Prohibitin an evalutionarily conserved intracellular protein that blocks DNA synthesis in normal fthroblasts and HeLa cells 显示文摘 | Nuell M J Stewart D A Walker L | 1991 | Mal Cell Biol1991，11，3： | 1 |
| 18 | Extremely low frequency plasmons in metallic mesostructures 显示文摘 | Pendry J B Holden A J Stewart W J | 1996 | Phys Rev Lett1996，76，5： | 1 |
| 19 | Multi-destination trip patterns显示文摘 | Stewart S I Vogt C A | 1997 | Annals of Tourism Research1997，24，2： | 1 |
| 20 | A contingency perspective on organizational learning: integrating environment context, organizational learning processes and types of learning 显示文摘 | GNYAWALI D R STEWART A C | 2003 | Management learning2003，34，1： | 1 |
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