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| 1 | 最新AD研究用诊断标准:IWG-2标准显示文摘在过去的8年中,国际工作组织(IWG)和美国国立老化研究院-阿尔茨海默协会(NIA-AA)建立了阿尔茨海默病(AD)诊断标准,它能更好地定义AD的临床表型,整合了生物标记物于诊断流程中,并覆盖了疾病的全程。本意见书充分地权衡了IWG标准的优缺点,建议改进诊断框架。依据这些改进,AD的诊断变得简单,只要有恰当的AD临床表型(典型或不典型)和与AD的病理相一致的病理生理学生物标志物出现。我们认为疾病的下游的定位性生物标志,如容积性磁共振成像(MRI)和氟脱氧葡萄糖-正电子发射型计算机断层成像(FDG-PET)等,适合更好地测量和监测疾病过程。本文还详述了非典型性AD、混合性AD和AD临床前期的特异诊断标准。 | 陈刚 曹雯炜 俞羚 糜建华 Dubois B Feldman HH Jacova C Hampel H Molinuevo JL Blennow K DeK osky ST Gauthier S Selkoe D Bateman R Cappa S Crutch S Engelborghs S Frisoni GB Fox NC Galasko D Habert MO Jicha GA Nordberg A Pasquier F Rabinovici G Robert P Rowe C Salloway S Sarazin M Epelbaum S de Souza LC Vellas B Visser PJ Schneider L Stern Y Scheltens P Cummings JL | 2014 | 神经病学与神经康复学杂志2014，11，3： | 31 |
| 2 | Neuregulin activa- tion of ErbB receptors in vascular endothelium leads to anglo- genesis显示文摘 | Russell K S Stern D F Polverini P J | 1999 | Am J Physiol1999，277，62： | 1 |
| 3 | Hydrogen Peroxide Catalytic Oxidation of Refractory Organics in Municipal Waste Water显示文摘 | D F Bishop G Stern | 1968 | I & EC Process Design and Development1968，7，1： | 1 |
| 4 | Verification and validation of RANS maneuvering simulation of Esso Osaka: effects of drift and rudder angle forces and moments显示文摘 | Simonsen C D Stern F | 2003 | Computers and Fluids2003，32，： | 1 |
| 5 | A Domain and TypeEnforcement UNIX Prototype显示文摘 | Badger L Sterne D F Sherman D L | 1996 | USENIX Computing Systems1996，9，1： | 1 |
| 6 | Coronavirus proteins: biogenesis of avian infectious bronchitis virus virion proteins 显示文摘 | Stern D F Sefton B F | 1982 | J Virol1982，44，： | 1 |
| 7 | Neuregulin-regulated gene expression in mammary carcinoma cells显示文摘 | Amin D N Tuck D Stern D F | 2005 | Exp Cell Res2005，309，1： | 1 |
| 8 | Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from Human B-lymphoblastoid cells显示文摘 | Stern A S Podlaski F J Hulmes J D | | 0，，： | 1 |
| 9 | Interaction of chromatin-associated Plkl and Mcm7 显示文摘 | Tsvetkov L Stern D F | 2005 | J Biol Chem2005，280，11： | 1 |
| 10 | The biology of erbB-2/neu/HER- 2 and its role in cancer 显示文摘 | Hynes N E Stern D F | 1994 | Biochim Biophys Acta1994，1198，23： | 1 |
| 11 | NFBD1/MDC1 regulates ionizing radiation-induced focus formation by DNA cheekpoint signaling and repair faetors 显示文摘 | Xu X Z Stern D F | 2003 | FASEB J2003，17，13： | 1 |
| 12 | Specificity within the EFG family/ErbB recep tor family signaling network显示文摘 | Rese D J Stern D F | 1998 | Bioessay1998，20，8： | 1 |
| 13 | Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells显示文摘 | STERN A S PODLASKI F J HULMES J D | 1990 | Proc Natl Acad Sci USA1990，87，17： | 1 |
| 14 | RANS maneuvering simula tion of Esso Osaka with rudder and a body-force pro peller显示文摘 | Simonsen C D Stern F | 2005 | Journal of Ship Research2005，49，2： | 1 |
| 15 | Campylobacter jejuni -an emerging foodborne pathogen显示文摘 | Altekused S F Stern N J Fields P I Swerdlow D L | 1999 | Emerg Infect Dis1999，5，： | 1 |
| 16 | Coronavirus protein: biogenesis of avian infectious bronchitis virus virion proteins显示文摘 | STERN D F SEFTON B M | 1982 | J Virol1982，44，3： | 1 |
| 17 | The new oncogene: an erb-B-related gene encoding a 185,000-Mrtumour antigen 显示文摘 | Schechter A L Stern D F Vaidyanathan I | 1984 | Nature1984，312，10： | 1 |
| 18 | 显示文摘 | Sayers D E Stern E A Lytle F | 1971 | Phys Rev Lett1971，27，： | 1 |
| 19 | 显示文摘 | Sayers D E Lytle F Stern E A | 1970 | Adv X-ray Anal1970，13，： | 1 |
| 20 | How ambitious are China and India's emissions intensity targets? 显示文摘 | Stern D Jotzo F | 2010 | Energy Policy2010，38，11： | 1 |
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