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| 1 | An integrated approach for increasing breeding efficiency in apple and peach in Europe显示文摘Despite the availability of whole genome sequences of apple and peach,there has been a considerable gap between genomics and breeding.To bridge the gap,the European Union funded the FruitBreedomics project(March 2011 to August 2015)involving 28 research institutes and private companies.Three complementary approaches were pursued:(i)tool and software development,(ii)deciphering genetic control of main horticultural traits taking into account allelic diversity and(iii)developing plant materials,tools and methodologies for breeders.Decisive breakthroughs were made including the making available of ready-to-go DNA diagnostic tests for Marker Assisted Breeding,development of new,dense SNP arrays in apple and peach,new phenotypic methods for some complex traits,software for gene/QTL discovery on breeding germplasm via Pedigree Based Analysis(PBA).This resulted in the discovery of highly predictive molecular markers for traits of horticultural interest via PBA and via Genome Wide Association Studies(GWAS)on several European genebank collections.FruitBreedomics also developed pre-breeding plant materials in which multiple sources of resistance were pyramided and software that can support breeders in their selection activities.Through FruitBreedomics,significant progresses were made in the field of apple and peach breeding,genetics,genomics and bioinformatics of which advantage will be made by breeders,germplasm curators and scientists.A major part of the data collected during the project has been stored in the FruitBreedomics database and has been made available to the public.This review covers the scientific discoveries made in this major endeavour,and perspective in the apple and peach breeding and genomics in Europe and beyond. | Francois Laurens Maria JoséAranzana Pere Arus Daniele Bassi Marco Bink Joan Bonany Andrea Caprera Luca Corelli-Grappadelli Evelyne Costes Charles-Eric Durel Jehan-Baptiste Mauroux Hélène Muranty Nelson Nazzicari Thierry Pascal Andrea Patocchi Andreas Peil Bénédicte Quilot-Turion Laura Rossini Alessandra Stella Michela Troggio Riccardo Velasco Eric van de Weg | 2018 | Horticulture Research2018，5，1： | 10 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Self-organization of multiple spatial and context memories in the hippocampus 显示文摘 | Stella F Cerasti E Si B | 2012 | Neurosci Biobehav Rev2012，36，7： | 1 |
| 4 | Atrazine and Cancer Incidence Among Pesticide Applicators in the Agricultural Health Study (1994-2007)显示文摘 | Beane Freeman Laura E Rusiecki Jennifer A Hoppin Jane A Lubin Jay H Koutros Stella Andreotti Gabriella Zahm Sheila Hoar Hines Cynthia J Coble Joseph B Barone-Adesi Francesco Sloan Jennifer Sandler Dale P Blair Aaron Alavanja Michael C R | 2011 | Environmental Health Perspectives2011，，9： | 1 |
| 5 | Effects of hu- man activities on wild pygmy marmosets in Ecuadorian Amazonia 显示文摘 | STELLA D L T CHARLES T S MONSERRAT B | 2000 | Biological Conservation2000，94，2： | 1 |
| 6 | Susceptibility of human metabolic phenotypes to dietary modulation 显示文摘 | Stella C Beckwith - Hall B Cloarec O | 2006 | J Proteome Res2006，5，10： | 1 |
| 7 | Design of follc acid-conjugnted nanoparticles for drug targeting显示文摘 | Stella B Arpicco S Peracchia M T | 2000 | Phann Sci2000，89，： | 1 |
| 8 | Encapsulation of gem- citabine lipophilic derivatives into polycyanoacrylate nanospheres and nanocapsules显示文摘 | Stella B Arpiceo S Rocco F | 2007 | Int J Pharm2007，344，12： | 1 |
| 9 | The 2015 Canadian hyper- tension education program recommendations for blood pressure measurement, diagnosis, assessment of risk, prevention, and treatment of hypertension 显示文摘 | Stella S Doreen M Kelly B | 2015 | Canadian Journal of Cardiolo- gy2015，31，： | 1 |
| 10 | Identification of selectionsignatures in cattle breeds selected for dairy production 显示文摘 | Stella A Ajmone-Marsan P Lazzari B | 2010 | Genet-ics2010，185，： | 1 |
| 11 | Susceptibility of human metabolic phenotypes to dietary modulation 显示文摘 | Stella C Hall B B Clorec O | 2006 | Journal of Proteome Research2006，5，10： | 1 |
| 12 | Crisis Management and Recovery: How Restaurant in Hong Kong Responded to SARS显示文摘 | Alan C Tse B Stella So | 2006 | Inter J Hos Manage2006，25，1： | 1 |
| 13 | Analysis of failure in the treatment of impacted maxillary canines显示文摘 | Adrian B Gavriel C Stella C | | 0，，06： | 1 |
| 14 | Design of folic acid-conjugated nanoparticles for drug targeting 显示文摘 | Stella B Arpicco S Peracchia MT | 2000 | J Pharm Sci2000，89，11： | 1 |
| 15 | Design of folic acid-conjugated nanoparticles for drug targeting显示文摘 | Stella B Arpiceo S Peracchia M T etal | 2000 | J Pharm Sci2000，89，11： | 1 |
| 16 | ESTree db: a tool for peach functional genomics显示文摘 | LAZZARI B CAPRERA A VECCHIETTI A STELLA A MILANESI L POZZI C | 2005 | BMC Bioinformatics2005，6，4： | 1 |
| 17 | Design of folic acid-conjugated nanoparticles for drug targeting显示文摘 | Stella B Arpicco S Peracchia M T | 2000 | Journal of Pharmaceutical Sciences2000，89，11： | 1 |
| 18 | Macromolecules as tax- ane delivery systems显示文摘 | Dosio F Stella B Arpieeo S | 2011 | Expert Opin Drug Deliv2011，8，1： | 1 |
| 19 | A High quality draft consensus sequence of the genome of a heterozygous grapevine variety显示文摘 | VELASCO R ZHARKIKH A TROGGIO M CARTWRIGHT DA CESTARO A PRUSS D PINDO M FITZGERALD LM VEZZULLI S REID J MALACARNE G ILIEV D COPPOLA G WARDELL B MICHELETTI D MACALMA T FACCI M MITCHELL JT PERAZZOLLI M ELDREDGE G GATTO P OYZERSKI R MORETTO M GUTIN N STEFANINI M CHEN Y SEGALA C DAVENPORT C DEMATYTE L MRAZ A BAT- TILANA J STORMO K COSTA F TAO Q SI-AMMOUR A HARKINS T LACKEY A PERBOST C TAILLON B STELLA A SOLOVYEV V FAWCETY JA STERCK L VANDEPOELE K GRANDO SM TOPPO S MOSER C LANCHBURY J BOGDEN R SKOLNICK M SGARAMELLA V BHATNAGAR SK FONTANA P GUTIN A VAN DE PEER Y SALAMINI F VIOLA R | 2007 | PLoS One2007，2，： | 1 |
| 20 | Self-organization of multiple spa- tial and context memories in the hippocampus显示文摘 | Stella F Cerasti E Si B | 2012 | Neurosci Biobehav Rev2012，36，7： | 1 |
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